inclusion criteria for pulmonary tuberculosis patients: 1. pulmonary tuberculosis patients aged 18-75 years who have not received covid-19 vaccine. 2. the condition is determined to be stable by the clinician. 3. the subjects can provide with informed consent and sign informed consent form (icf). 4. the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. 5. axillary temperature ≤ 37.0℃. inclusion criteria for healthy participants: 1.healthy subjects aged 18-75 years who have not received covid-19 vaccine. 2.the subjects can provide with informed consent and sign informed consent form (icf). 3.the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. 4.axillary temperature ≤ 37.0℃. exclusion criteria for the first vaccination 1. medical history or family history of convulsion, epilepsy, encephalopathy and psychosis. 2. hiv positive. 3. cancer patients under treatment. 4. allergic to any component of the research vaccines, or a history of hypersensitivity or serious reactions to vaccination. 5. women with positive urine pregnancy test, pregnant or breast-feeding, or have a pregnancy plan in this study. 6. severe chronic diseases or condition in progress cannot be controlled.( grade 3 or higher as defined in the guidelines for the classification of adverse events in clinical trials for prophylactic vaccines). 7. transaminase ≥ 3 times uln or total bilirubin ≥2 times uln, or other serious adverse reactions as determined by the clinician for antituberculosis treatment. 8. congenital or acquired angioedema / neuroedema. 9. asplenia or functional asplenia. 10. thrombocytopenia or other clotting disorder (this may contraindicate intramuscular injection). 11. immunosuppressant therapy, antiallergic therapy, cytotoxic therapy, high dose inhaled corticosteroid over the past 6 months (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid for acute non-complicated dermatitis, and corticosteroid with dose less than 20mg/ day) 12. received blood products within 4 months before vaccination. 13. received other investigational drugs within 1 month prior to receiving the investigational vaccines. 14. received other live attenuated vaccines within 1 month prior to receiving the investigational vaccines. 15. received subunit or inactivated vaccine within 14 days prior to receiving investigational vaccine. 16. any medical, psychological, social or other conditions that, in the investigator's judgment, are inconsistent with the study protocol or affect the subjects' informed consent exclusion criteria for subsequent vaccination 1.those who have had a severe allergic reaction after a previous dose of vaccine. 2.serious adverse events causally related to the previous vaccination. 3.the newly discovered or newly emerging cases who don't meet the inclusion criteria or meet the exclusion criteria for the first dose, the investigator will decide whether they will continue to participate in the study. 4.other reasons the investigator consider for exclusion.

inclusion criteria for pulmonary tuberculosis patients: 1. pulmonary tuberculosis patients aged 18-75 years who have not received covid-19 vaccine. 2. the condition is determined to be stable by the clinician. 3. the subjects can provide with informed consent and sign informed consent form (icf). 4. the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. 5. axillary temperature ≤ 37.0℃. inclusion criteria for healthy participants: 1.healthy subjects aged 18-75 years who have not received covid-19 vaccine. 2.the subjects can provide with informed consent and sign informed consent form (icf). 3.the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. 4.axillary temperature ≤ 37.0℃. exclusion criteria for the first vaccination 1. medical history or family history of convulsion, epilepsy, encephalopathy and psychosis. 2. hiv positive. 3. cancer patients under treatment. 4. allergic to any component of the research vaccines, or a history of hypersensitivity or serious reactions to vaccination. 5. women with positive urine pregnancy test, pregnant or breast-feeding, or have a pregnancy plan in this study. 6. severe chronic diseases or condition in progress cannot be controlled.( grade 3 or higher as defined in the guidelines for the classification of adverse events in clinical trials for prophylactic vaccines). 7. transaminase ≥ 3 times uln or total bilirubin ≥2 times uln, or other serious adverse reactions as determined by the clinician for antituberculosis treatment. 8. congenital or acquired angioedema / neuroedema. 9. asplenia or functional asplenia. 10. thrombocytopenia or other clotting disorder (this may contraindicate intramuscular injection). 11. immunosuppressant therapy, antiallergic therapy, cytotoxic therapy, high dose inhaled corticosteroid over the past 6 months (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid for acute non-complicated dermatitis, and corticosteroid with dose less than 20mg/ day) 12. received blood products within 4 months before vaccination. 13. received other investigational drugs within 1 month prior to receiving the investigational vaccines. 14. received other live attenuated vaccines within 1 month prior to receiving the investigational vaccines. 15. received subunit or inactivated vaccine within 14 days prior to receiving investigational vaccine. 16. any medical, psychological, social or other conditions that, in the investigator's judgment, are inconsistent with the study protocol or affect the subjects' informed consent exclusion criteria for subsequent vaccination 1.those who have had a severe allergic reaction after a previous dose of vaccine. 2.serious adverse events causally related to the previous vaccination. 3.the newly discovered or newly emerging cases who don't meet the inclusion criteria or meet the exclusion criteria for the first dose, the investigator will decide whether they will continue to participate in the study. 4.other reasons the investigator consider for exclusion.

inclusion criteria for pulmonary tuberculosis patients: pulmonary tuberculosis patients aged 18-75 years who have not received covid-19 vaccine. the condition is determined to be stable by the clinician. the subjects can provide with informed consent and sign informed consent form (icf). the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. axillary temperature ≤ 37.0℃. inclusion criteria for healthy participants: 1.healthy subjects aged 18-75 years who have not received covid-19 vaccine. 2.the subjects can provide with informed consent and sign informed consent form (icf). 3.the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. 4.axillary temperature ≤ 37.0℃. exclusion criteria for the first vaccination medical history or family history of convulsion, epilepsy, encephalopathy and psychosis. hiv positive. cancer patients under treatment. allergic to any component of the research vaccines, or a history of hypersensitivity or serious reactions to vaccination. women with positive urine pregnancy test, pregnant or breast-feeding, or have a pregnancy plan in this study. severe chronic diseases or condition in progress cannot be controlled.( grade 3 or higher as defined in the guidelines for the classification of adverse events in clinical trials for prophylactic vaccines). transaminase ≥ 3 times uln or total bilirubin ≥2 times uln, or other serious adverse reactions as determined by the clinician for antituberculosis treatment. congenital or acquired angioedema / neuroedema. asplenia or functional asplenia. thrombocytopenia or other clotting disorder (this may contraindicate intramuscular injection). immunosuppressant therapy, antiallergic therapy, cytotoxic therapy, high dose inhaled corticosteroid over the past 6 months (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid for acute non-complicated dermatitis, and corticosteroid with dose less than 20mg/ day) received blood products within 4 months before vaccination. received other investigational drugs within 1 month prior to receiving the investigational vaccines. received other live attenuated vaccines within 1 month prior to receiving the investigational vaccines. received subunit or inactivated vaccine within 14 days prior to receiving investigational vaccine. any medical, psychological, social or other conditions that, in the investigator's judgment, are inconsistent with the study protocol or affect the subjects' informed consent exclusion criteria for subsequent vaccination 1.those who have had a severe allergic reaction after a previous dose of vaccine. 2.serious adverse events causally related to the previous vaccination. 3.the newly discovered or newly emerging cases who don't meet the inclusion criteria or meet the exclusion criteria for the first dose, the investigator will decide whether they will continue to participate in the study. 4.other reasons the investigator consider for exclusion.

inclusion criteria for pulmonary tuberculosis patients: pulmonary tuberculosis patients aged 18-75 years who have not received covid-19 vaccine. the condition is determined to be stable by the clinician. the subjects can provide with informed consent and sign informed consent form (icf). the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. axillary temperature ≤ 37.0℃. inclusion criteria for healthy participants: 1.healthy subjects aged 18-75 years who have not received covid-19 vaccine. 2.the subjects can provide with informed consent and sign informed consent form (icf). 3.the subjects are able to and willing to comply with the requirements of the clinical trial program and could complete the follow-up of the study. 4.axillary temperature ≤ 37.0℃. exclusion criteria for the first vaccination medical history or family history of convulsion, epilepsy, encephalopathy and psychosis. hiv positive. cancer patients under treatment. allergic to any component of the research vaccines, or a history of hypersensitivity or serious reactions to vaccination. women with positive urine pregnancy test, pregnant or breast-feeding, or have a pregnancy plan in this study. severe chronic diseases or condition in progress cannot be controlled.( grade 3 or higher as defined in the guidelines for the classification of adverse events in clinical trials for prophylactic vaccines). transaminase ≥ 3 times uln or total bilirubin ≥2 times uln, or other serious adverse reactions as determined by the clinician for antituberculosis treatment. congenital or acquired angioedema / neuroedema. asplenia or functional asplenia. thrombocytopenia or other clotting disorder (this may contraindicate intramuscular injection). immunosuppressant therapy, antiallergic therapy, cytotoxic therapy, high dose inhaled corticosteroid over the past 6 months (excluding corticosteroid spray for allergic rhinitis, surface corticosteroid for acute non-complicated dermatitis, and corticosteroid with dose less than 20mg/ day) received blood products within 4 months before vaccination. received other investigational drugs within 1 month prior to receiving the investigational vaccines. received other live attenuated vaccines within 1 month prior to receiving the investigational vaccines. received subunit or inactivated vaccine within 14 days prior to receiving investigational vaccine. any medical, psychological, social or other conditions that, in the investigator's judgment, are inconsistent with the study protocol or affect the subjects' informed consent exclusion criteria for subsequent vaccination 1.those who have had a severe allergic reaction after a previous dose of vaccine. 2.serious adverse events causally related to the previous vaccination. 3.the newly discovered or newly emerging cases who don't meet the inclusion criteria or meet the exclusion criteria for the first dose, the investigator will decide whether they will continue to participate in the study. 4.other reasons the investigator consider for exclusion.