a volunteer will not be included in the study if at least one of the following criteria is met: 1. drug intolerance to any drug; 2. relevant history of allergies 3. lactase deficiency, lactose intolerance, glucose-galactose malabsorption; 4. acute infectious diseases or allergic reactions requiring treatment (including drug allergies) less than 4 weeks before the first day of screening; 5. surgical interventions on the gastrointestinal tract (except appendectomy); 6. volunteers with suspected hypersensitivity to study drugs or any of their components; 7. chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, blood or other conditions that make it impossible for a volunteer to participate in the study, according to the researcher; 8. the results of standard laboratory and instrumental examination tests obtained during the screening, which go beyond the normal values; 9. a positive result for at least one of the following tests: 10. blood test for hiv; 11. blood test for syphilis; 12. blood test for hepatitis b; 13. blood test for hepatitis c; 14. positive aob results; 15. positive results of urine test for the content of narcotic and potent substances; 16. positive urine pregnancy test results in female volunteers; 17. any diet, such as a vegetarian diet, within 2 weeks of the first day of screening; 18. reception of more than 10 units. alcohol per week (1 unit of alcohol is equivalent to ½ liter of beer, 200 ml of wine or 50 ml of strong alcoholic beverages) or history of alcoholism, drug addiction, drug abuse; 19. inability to go without food for at least 12 hours and inability to take the drug on an empty stomach; 20. donation of blood (450 ml of blood or plasma and more) less than 3 months before the first day of screening; 21. depot injections, installation of intrauterine hormonal therapeutic systems or implants of any drugs 6 months before the first day of screening; 22. for females: use of hormonal contraceptives less than 2 months before the first day of screening; 23. regular medicinal drug intake less than 2 weeks before the first day of screening; 24. taking medications that have a pronounced effect on hemodynamics, the function of liver microsomal enzymes, the function of the gastrointestinal tract, etc. (barbiturates, omeprazole, cimetidine, etc.), vitamins and or dietary supplements less than 30 days before the first day of screening; 25. for females: volunteers with preserved reproductive potential who had unprotected intercourse with an unsterilized male partner within 30 days before the first day of screening; 26. for females: breast-feeding period 27. participation in any other clinical trial or study drug intake less than 3 months before the first day of screening; 28. difficulty accessing a vein, making it difficult or impossible to insert a catheter and perform a frequent blood sampling; 29. smoking. 30. volunteers unwilling or unable to give up alcohol and excessive exercise from the first day of screening to the follow-up visit; 31. volunteers who are unwilling or unable to avoid food and drinks containing methylxanthines and grapefruit / grapefruit juice from the first day of screening to the follow-up visit; 32. volunteers with lifestyles (including night work and extreme physical activity such as sports or weight lifting) that can make it difficult to interpret laboratory findings from the study; 33. volunteers who do not intend to comply with the research regime and / or are not credible to the researcher; 34. volunteers who are clearly or likely, in the opinion of the researcher, are not able to understand and evaluate the information on this research as part of the informed consent form signing process, in particular regarding the expected risks and possible discomfort; 35. dehydration due to diarrhea, vomiting or other reason within the last 24 hours before the first day of screening; 36. a history of seizures, epilepsy and any other neurological disorders; criteria of exclusion (withdrawn of a volunteer from the study at the initiative of the researcher): 1. the researcher decided that the volunteer should be excluded in the interests of the volunteer; 2. non-compliance with the exclusion criteria identified during the study. deviations of indicators of vital body functions, as well as standard laboratory and instrumental indicators from the established normal values, detected after the volunteer took the study drug, are considered an undesirable phenomenon; 3. the occurrence of aes / saes when the continuation of the volunteer's participation in the study is undesirable or impossible (according to the sponsor / manufacturer or researcher); 4. vomiting or diarrhea within 8 hours after taking the drug; 5. unauthorized concomitant treatment (protocol violation); 6. non-compliance by the volunteer with the rules of stay at the clinical base; 7. the volunteer is receiving additional treatment (or needs additional treatment, including the use of additional drugs) that may affect the pharmacokinetics of the study drugs; 8. the volunteer requires inpatient treatment during the study; 9. volunteers arrive at the hospital later than the appointed time (more than 1 hour late), which violates the protocol requirements; 10. positive aob results; 11. positive pregnancy test; 12. positive results of urine test for the content of narcotic and potent substances; 13. in the adverse events that the resulting side effects of the drug are so serious that continuation of the study is unacceptable. the expulsion of the volunteer at the initiative of the researcher.

a volunteer will not be included in the study if at least one of the following criteria is met: 1. drug intolerance to any drug; 2. relevant history of allergies 3. lactase deficiency, lactose intolerance, glucose-galactose malabsorption; 4. acute infectious diseases or allergic reactions requiring treatment (including drug allergies) less than 4 weeks before the first day of screening; 5. surgical interventions on the gastrointestinal tract (except appendectomy); 6. volunteers with suspected hypersensitivity to study drugs or any of their components; 7. chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, blood or other conditions that make it impossible for a volunteer to participate in the study, according to the researcher; 8. the results of standard laboratory and instrumental examination tests obtained during the screening, which go beyond the normal values; 9. a positive result for at least one of the following tests: 10. blood test for hiv; 11. blood test for syphilis; 12. blood test for hepatitis b; 13. blood test for hepatitis c; 14. positive aob results; 15. positive results of urine test for the content of narcotic and potent substances; 16. positive urine pregnancy test results in female volunteers; 17. any diet, such as a vegetarian diet, within 2 weeks of the first day of screening; 18. reception of more than 10 units. alcohol per week (1 unit of alcohol is equivalent to ½ liter of beer, 200 ml of wine or 50 ml of strong alcoholic beverages) or history of alcoholism, drug addiction, drug abuse; 19. inability to go without food for at least 12 hours and inability to take the drug on an empty stomach; 20. donation of blood (450 ml of blood or plasma and more) less than 3 months before the first day of screening; 21. depot injections, installation of intrauterine hormonal therapeutic systems or implants of any drugs 6 months before the first day of screening; 22. for females: use of hormonal contraceptives less than 2 months before the first day of screening; 23. regular medicinal drug intake less than 2 weeks before the first day of screening; 24. taking medications that have a pronounced effect on hemodynamics, the function of liver microsomal enzymes, the function of the gastrointestinal tract, etc. (barbiturates, omeprazole, cimetidine, etc.), vitamins and or dietary supplements less than 30 days before the first day of screening; 25. for females: volunteers with preserved reproductive potential who had unprotected intercourse with an unsterilized male partner within 30 days before the first day of screening; 26. for females: breast-feeding period 27. participation in any other clinical trial or study drug intake less than 3 months before the first day of screening; 28. difficulty accessing a vein, making it difficult or impossible to insert a catheter and perform a frequent blood sampling; 29. smoking. 30. volunteers unwilling or unable to give up alcohol and excessive exercise from the first day of screening to the follow-up visit; 31. volunteers who are unwilling or unable to avoid food and drinks containing methylxanthines and grapefruit / grapefruit juice from the first day of screening to the follow-up visit; 32. volunteers with lifestyles (including night work and extreme physical activity such as sports or weight lifting) that can make it difficult to interpret laboratory findings from the study; 33. volunteers who do not intend to comply with the research regime and / or are not credible to the researcher; 34. volunteers who are clearly or likely, in the opinion of the researcher, are not able to understand and evaluate the information on this research as part of the informed consent form signing process, in particular regarding the expected risks and possible discomfort; 35. dehydration due to diarrhea, vomiting or other reason within the last 24 hours before the first day of screening; 36. a history of seizures, epilepsy and any other neurological disorders; criteria of exclusion (withdrawn of a volunteer from the study at the initiative of the researcher): 1. the researcher decided that the volunteer should be excluded in the interests of the volunteer; 2. non-compliance with the exclusion criteria identified during the study. deviations of indicators of vital body functions, as well as standard laboratory and instrumental indicators from the established normal values, detected after the volunteer took the study drug, are considered an undesirable phenomenon; 3. the occurrence of aes / saes when the continuation of the volunteer's participation in the study is undesirable or impossible (according to the sponsor / manufacturer or researcher); 4. vomiting or diarrhea within 8 hours after taking the drug; 5. unauthorized concomitant treatment (protocol violation); 6. non-compliance by the volunteer with the rules of stay at the clinical base; 7. the volunteer is receiving additional treatment (or needs additional treatment, including the use of additional drugs) that may affect the pharmacokinetics of the study drugs; 8. the volunteer requires inpatient treatment during the study; 9. volunteers arrive at the hospital later than the appointed time (more than 1 hour late), which violates the protocol requirements; 10. positive aob results; 11. positive pregnancy test; 12. positive results of urine test for the content of narcotic and potent substances; 13. in the adverse events that the resulting side effects of the drug are so serious that continuation of the study is unacceptable. the expulsion of the volunteer at the initiative of the researcher.

a volunteer will not be included in the study if at least one of the following criteria is met: drug intolerance to any drug; relevant history of allergies lactase deficiency, lactose intolerance, glucose-galactose malabsorption; acute infectious diseases or allergic reactions requiring treatment (including drug allergies) less than 4 weeks before the first day of screening; surgical interventions on the gastrointestinal tract (except appendectomy); volunteers with suspected hypersensitivity to study drugs or any of their components; chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, blood or other conditions that make it impossible for a volunteer to participate in the study, according to the researcher; the results of standard laboratory and instrumental examination tests obtained during the screening, which go beyond the normal values; a positive result for at least one of the following tests: blood test for hiv; blood test for syphilis; blood test for hepatitis b; blood test for hepatitis c; positive aob results; positive results of urine test for the content of narcotic and potent substances; positive urine pregnancy test results in female volunteers; any diet, such as a vegetarian diet, within 2 weeks of the first day of screening; reception of more than 10 units. alcohol per week (1 unit of alcohol is equivalent to ½ liter of beer, 200 ml of wine or 50 ml of strong alcoholic beverages) or history of alcoholism, drug addiction, drug abuse; inability to go without food for at least 12 hours and inability to take the drug on an empty stomach; donation of blood (450 ml of blood or plasma and more) less than 3 months before the first day of screening; depot injections, installation of intrauterine hormonal therapeutic systems or implants of any drugs 6 months before the first day of screening; for females: use of hormonal contraceptives less than 2 months before the first day of screening; regular medicinal drug intake less than 2 weeks before the first day of screening; taking medications that have a pronounced effect on hemodynamics, the function of liver microsomal enzymes, the function of the gastrointestinal tract, etc. (barbiturates, omeprazole, cimetidine, etc.), vitamins and or dietary supplements less than 30 days before the first day of screening; for females: volunteers with preserved reproductive potential who had unprotected intercourse with an unsterilized male partner within 30 days before the first day of screening; for females: breast-feeding period participation in any other clinical trial or study drug intake less than 3 months before the first day of screening; difficulty accessing a vein, making it difficult or impossible to insert a catheter and perform a frequent blood sampling; smoking. volunteers unwilling or unable to give up alcohol and excessive exercise from the first day of screening to the follow-up visit; volunteers who are unwilling or unable to avoid food and drinks containing methylxanthines and grapefruit / grapefruit juice from the first day of screening to the follow-up visit; volunteers with lifestyles (including night work and extreme physical activity such as sports or weight lifting) that can make it difficult to interpret laboratory findings from the study; volunteers who do not intend to comply with the research regime and / or are not credible to the researcher; volunteers who are clearly or likely, in the opinion of the researcher, are not able to understand and evaluate the information on this research as part of the informed consent form signing process, in particular regarding the expected risks and possible discomfort; dehydration due to diarrhea, vomiting or other reason within the last 24 hours before the first day of screening; a history of seizures, epilepsy and any other neurological disorders; criteria of exclusion (withdrawn of a volunteer from the study at the initiative of the researcher): the researcher decided that the volunteer should be excluded in the interests of the volunteer; non-compliance with the exclusion criteria identified during the study. deviations of indicators of vital body functions, as well as standard laboratory and instrumental indicators from the established normal values, detected after the volunteer took the study drug, are considered an undesirable phenomenon; the occurrence of aes / saes when the continuation of the volunteer's participation in the study is undesirable or impossible (according to the sponsor / manufacturer or researcher); vomiting or diarrhea within 8 hours after taking the drug; unauthorized concomitant treatment (protocol violation); non-compliance by the volunteer with the rules of stay at the clinical base; the volunteer is receiving additional treatment (or needs additional treatment, including the use of additional drugs) that may affect the pharmacokinetics of the study drugs; the volunteer requires inpatient treatment during the study; volunteers arrive at the hospital later than the appointed time (more than 1 hour late), which violates the protocol requirements; positive aob results; positive pregnancy test; positive results of urine test for the content of narcotic and potent substances; in the adverse events that the resulting side effects of the drug are so serious that continuation of the study is unacceptable. the expulsion of the volunteer at the initiative of the researcher.

a volunteer will not be included in the study if at least one of the following criteria is met: drug intolerance to any drug; relevant history of allergies lactase deficiency, lactose intolerance, glucose-galactose malabsorption; acute infectious diseases or allergic reactions requiring treatment (including drug allergies) less than 4 weeks before the first day of screening; surgical interventions on the gastrointestinal tract (except appendectomy); volunteers with suspected hypersensitivity to study drugs or any of their components; chronic diseases of the cardiovascular, bronchopulmonary, neuroendocrine system, as well as diseases of the gastrointestinal tract, liver, kidneys, blood or other conditions that make it impossible for a volunteer to participate in the study, according to the researcher; the results of standard laboratory and instrumental examination tests obtained during the screening, which go beyond the normal values; a positive result for at least one of the following tests: blood test for hiv; blood test for syphilis; blood test for hepatitis b; blood test for hepatitis c; positive aob results; positive results of urine test for the content of narcotic and potent substances; positive urine pregnancy test results in female volunteers; any diet, such as a vegetarian diet, within 2 weeks of the first day of screening; reception of more than 10 units. alcohol per week (1 unit of alcohol is equivalent to ½ liter of beer, 200 ml of wine or 50 ml of strong alcoholic beverages) or history of alcoholism, drug addiction, drug abuse; inability to go without food for at least 12 hours and inability to take the drug on an empty stomach; donation of blood (450 ml of blood or plasma and more) less than 3 months before the first day of screening; depot injections, installation of intrauterine hormonal therapeutic systems or implants of any drugs 6 months before the first day of screening; for females: use of hormonal contraceptives less than 2 months before the first day of screening; regular medicinal drug intake less than 2 weeks before the first day of screening; taking medications that have a pronounced effect on hemodynamics, the function of liver microsomal enzymes, the function of the gastrointestinal tract, etc. (barbiturates, omeprazole, cimetidine, etc.), vitamins and or dietary supplements less than 30 days before the first day of screening; for females: volunteers with preserved reproductive potential who had unprotected intercourse with an unsterilized male partner within 30 days before the first day of screening; for females: breast-feeding period participation in any other clinical trial or study drug intake less than 3 months before the first day of screening; difficulty accessing a vein, making it difficult or impossible to insert a catheter and perform a frequent blood sampling; smoking. volunteers unwilling or unable to give up alcohol and excessive exercise from the first day of screening to the follow-up visit; volunteers who are unwilling or unable to avoid food and drinks containing methylxanthines and grapefruit / grapefruit juice from the first day of screening to the follow-up visit; volunteers with lifestyles (including night work and extreme physical activity such as sports or weight lifting) that can make it difficult to interpret laboratory findings from the study; volunteers who do not intend to comply with the research regime and / or are not credible to the researcher; volunteers who are clearly or likely, in the opinion of the researcher, are not able to understand and evaluate the information on this research as part of the informed consent form signing process, in particular regarding the expected risks and possible discomfort; dehydration due to diarrhea, vomiting or other reason within the last 24 hours before the first day of screening; a history of seizures, epilepsy and any other neurological disorders; criteria of exclusion (withdrawn of a volunteer from the study at the initiative of the researcher): the researcher decided that the volunteer should be excluded in the interests of the volunteer; non-compliance with the exclusion criteria identified during the study. deviations of indicators of vital body functions, as well as standard laboratory and instrumental indicators from the established normal values, detected after the volunteer took the study drug, are considered an undesirable phenomenon; the occurrence of aes / saes when the continuation of the volunteer's participation in the study is undesirable or impossible (according to the sponsor / manufacturer or researcher); vomiting or diarrhea within 8 hours after taking the drug; unauthorized concomitant treatment (protocol violation); non-compliance by the volunteer with the rules of stay at the clinical base; the volunteer is receiving additional treatment (or needs additional treatment, including the use of additional drugs) that may affect the pharmacokinetics of the study drugs; the volunteer requires inpatient treatment during the study; volunteers arrive at the hospital later than the appointed time (more than 1 hour late), which violates the protocol requirements; positive aob results; positive pregnancy test; positive results of urine test for the content of narcotic and potent substances; in the adverse events that the resulting side effects of the drug are so serious that continuation of the study is unacceptable. the expulsion of the volunteer at the initiative of the researcher.