* history of sars-cov-2 infection; * close contact with a confirmed covid-19 within 14 days prior to randomization; * prior administration of an investigational coronavirus vaccine or current/ planned simultaneous participation in another interventional study to prevent or treat covid-19; * allergy to vaccines or vaccine/placebo ingredients, and serious adverse reactions to vaccines, such as urticaria, dyspnea, angioneuroedema; * personal or first-grade relative (siblings) history of multisystem inflammatory disease in children (mis-c); * significant chronic illnesses that, in the opinion of the investigator, is at a stage where it might interfere with trial conduct or completion (may include, but are not limited to cardiovascular disease, liver or kidney disorders, respiratory illnesses); * significant chronic central nervous system diseases or neuromuscular disorders, psychosis or severe cognitive behavioral disorder, in the opinion of the investigator, including epilepsy, autism spectrum disorder, intellectual disabilities (excluding down syndrome); * acute central nervous system diseases such as encephalitis/myelitis, acute disseminating encephalomyelitis, and related disorders; * history of autoimmune and/or haematological diseases (including but not limited to systemic lupus erythematosus, thyroidectomy, autoimmune thyroid disease, any form of malignant tumor, asplenia, functional asplenia, or splenectomy resulting from any condition); well controlled type i diabetes mellitus is allowed; * history of bleeding disorders (e.g. factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture; * immunosuppressive therapy (systemic corticoid therapy, e.g. prednisone ≥2 mg/kg/d or ≥20 mg/day for \>14 days), cytotoxic therapy (antineoplastic chemotherapy, radiation therapy), (excluding topical or aerosol corticosteroid therapy) in the past 6 months; * receipt of blood products or immunoglobulins in the past 3 months; * receipt of other investigational drugs in the past 30 days; * receipt of attenuated live vaccines in the past 14 days; * receipt of inactivated or subunit vaccines in the past 7 days; * acute exacerbation or presentation of stable chronic diseases (including but not limited to asthma, migraine, gastrointestinal disorder, etc; * acute febrile illness with oral temperature \>37.7°c ,enrollment could be considered if the fever is absent for 72 hours; * any confirmed or suspected human immunodeficiency virus (hiv) infection; * children in care or under a court order; * according to the investigator's judgment, the subject has any other factors that might interfere with the results of the clinical trial or pose additional risk to the subject due to participation in the study.

* history of sars-cov-2 infection; * close contact with a confirmed covid-19 within 14 days prior to randomization; * prior administration of an investigational coronavirus vaccine or current/ planned simultaneous participation in another interventional study to prevent or treat covid-19; * allergy to vaccines or vaccine/placebo ingredients, and serious adverse reactions to vaccines, such as urticaria, dyspnea, angioneuroedema; * personal or first-grade relative (siblings) history of multisystem inflammatory disease in children (mis-c); * significant chronic illnesses that, in the opinion of the investigator, is at a stage where it might interfere with trial conduct or completion (may include, but are not limited to cardiovascular disease, liver or kidney disorders, respiratory illnesses); * significant chronic central nervous system diseases or neuromuscular disorders, psychosis or severe cognitive behavioral disorder, in the opinion of the investigator, including epilepsy, autism spectrum disorder, intellectual disabilities (excluding down syndrome); * acute central nervous system diseases such as encephalitis/myelitis, acute disseminating encephalomyelitis, and related disorders; * history of autoimmune and/or haematological diseases (including but not limited to systemic lupus erythematosus, thyroidectomy, autoimmune thyroid disease, any form of malignant tumor, asplenia, functional asplenia, or splenectomy resulting from any condition); well controlled type i diabetes mellitus is allowed; * history of bleeding disorders (e.g. factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture; * immunosuppressive therapy (systemic corticoid therapy, e.g. prednisone ≥2 mg/kg/d or ≥20 mg/day for \>14 days), cytotoxic therapy (antineoplastic chemotherapy, radiation therapy), (excluding topical or aerosol corticosteroid therapy) in the past 6 months; * receipt of blood products or immunoglobulins in the past 3 months; * receipt of other investigational drugs in the past 30 days; * receipt of attenuated live vaccines in the past 14 days; * receipt of inactivated or subunit vaccines in the past 7 days; * acute exacerbation or presentation of stable chronic diseases (including but not limited to asthma, migraine, gastrointestinal disorder, etc; * acute febrile illness with oral temperature \>37.7°c ,enrollment could be considered if the fever is absent for 72 hours; * any confirmed or suspected human immunodeficiency virus (hiv) infection; * children in care or under a court order; * according to the investigator's judgment, the subject has any other factors that might interfere with the results of the clinical trial or pose additional risk to the subject due to participation in the study.

history of sars-cov-2 infection; close contact with a confirmed covid-19 within 14 days prior to randomization; prior administration of an investigational coronavirus vaccine or current/ planned simultaneous participation in another interventional study to prevent or treat covid-19; allergy to vaccines or vaccine/placebo ingredients, and serious adverse reactions to vaccines, such as urticaria, dyspnea, angioneuroedema; personal or first-grade relative (siblings) history of multisystem inflammatory disease in children (mis-c); significant chronic illnesses that, in the opinion of the investigator, is at a stage where it might interfere with trial conduct or completion (may include, but are not limited to cardiovascular disease, liver or kidney disorders, respiratory illnesses); significant chronic central nervous system diseases or neuromuscular disorders, psychosis or severe cognitive behavioral disorder, in the opinion of the investigator, including epilepsy, autism spectrum disorder, intellectual disabilities (excluding down syndrome); acute central nervous system diseases such as encephalitis/myelitis, acute disseminating encephalomyelitis, and related disorders; history of autoimmune and/or haematological diseases (including but not limited to systemic lupus erythematosus, thyroidectomy, autoimmune thyroid disease, any form of malignant tumor, asplenia, functional asplenia, or splenectomy resulting from any condition); well controlled type i diabetes mellitus is allowed; history of bleeding disorders (e.g. factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture; immunosuppressive therapy (systemic corticoid therapy, e.g. prednisone ≥2 mg/kg/d or ≥20 mg/day for >14 days), cytotoxic therapy (antineoplastic chemotherapy, radiation therapy), (excluding topical or aerosol corticosteroid therapy) in the past 6 months; receipt of blood products or immunoglobulins in the past 3 months; receipt of other investigational drugs in the past 30 days; receipt of attenuated live vaccines in the past 14 days; receipt of inactivated or subunit vaccines in the past 7 days; acute exacerbation or presentation of stable chronic diseases (including but not limited to asthma, migraine, gastrointestinal disorder, etc; acute febrile illness with oral temperature >37.7°c ,enrollment could be considered if the fever is absent for 72 hours; any confirmed or suspected human immunodeficiency virus (hiv) infection; children in care or under a court order; according to the investigator's judgment, the subject has any other factors that might interfere with the results of the clinical trial or pose additional risk to the subject due to participation in the study.

history of sars-cov-2 infection; close contact with a confirmed covid-19 within 14 days prior to randomization; prior administration of an investigational coronavirus vaccine or current/ planned simultaneous participation in another interventional study to prevent or treat covid-19; allergy to vaccines or vaccine/placebo ingredients, and serious adverse reactions to vaccines, such as urticaria, dyspnea, angioneuroedema; personal or first-grade relative (siblings) history of multisystem inflammatory disease in children (mis-c); significant chronic illnesses that, in the opinion of the investigator, is at a stage where it might interfere with trial conduct or completion (may include, but are not limited to cardiovascular disease, liver or kidney disorders, respiratory illnesses); significant chronic central nervous system diseases or neuromuscular disorders, psychosis or severe cognitive behavioral disorder, in the opinion of the investigator, including epilepsy, autism spectrum disorder, intellectual disabilities (excluding down syndrome); acute central nervous system diseases such as encephalitis/myelitis, acute disseminating encephalomyelitis, and related disorders; history of autoimmune and/or haematological diseases (including but not limited to systemic lupus erythematosus, thyroidectomy, autoimmune thyroid disease, any form of malignant tumor, asplenia, functional asplenia, or splenectomy resulting from any condition); well controlled type i diabetes mellitus is allowed; history of bleeding disorders (e.g. factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following im injections or venipuncture; immunosuppressive therapy (systemic corticoid therapy, e.g. prednisone ≥2 mg/kg/d or ≥20 mg/day for >14 days), cytotoxic therapy (antineoplastic chemotherapy, radiation therapy), (excluding topical or aerosol corticosteroid therapy) in the past 6 months; receipt of blood products or immunoglobulins in the past 3 months; receipt of other investigational drugs in the past 30 days; receipt of attenuated live vaccines in the past 14 days; receipt of inactivated or subunit vaccines in the past 7 days; acute exacerbation or presentation of stable chronic diseases (including but not limited to asthma, migraine, gastrointestinal disorder, etc; acute febrile illness with oral temperature >37.7°c ,enrollment could be considered if the fever is absent for 72 hours; any confirmed or suspected human immunodeficiency virus (hiv) infection; children in care or under a court order; according to the investigator's judgment, the subject has any other factors that might interfere with the results of the clinical trial or pose additional risk to the subject due to participation in the study.