inclusion criteria: to be considered eligible to participate in this study, the subject must meet all of the inclusion criteria listed below: * hospitalized patients age ≥ 18 with diagnosis of sars-cov-2-infection based on positive * pcr test result and can provide informed consent * diagnosed with pneumonia due to sars-cov-2 * respiratory rate ≥ 25/minute and spo2 ≤ 93% * review of chest radiograph, chest computed tomography (ct) scan, or chest ultrasound consistent with bilateral infiltrates. * horowitz index (partial pressure of oxygen/fraction of inspired oxygen \[pao2/fio2\]) ≤ 300. if a subject does not have an arterial line in place, a spo2/fio2 ≤ 315 may be used.

inclusion criteria: to be considered eligible to participate in this study, the subject must meet all of the inclusion criteria listed below: * hospitalized patients age ≥ 18 with diagnosis of sars-cov-2-infection based on positive * pcr test result and can provide informed consent * diagnosed with pneumonia due to sars-cov-2 * respiratory rate ≥ 25/minute and spo2 ≤ 93% * review of chest radiograph, chest computed tomography (ct) scan, or chest ultrasound consistent with bilateral infiltrates. * horowitz index (partial pressure of oxygen/fraction of inspired oxygen \[pao2/fio2\]) ≤ 300. if a subject does not have an arterial line in place, a spo2/fio2 ≤ 315 may be used.

inclusion criteria: to be considered eligible to participate in this study, the subject must meet all of the inclusion criteria listed below: hospitalized patients age ≥ 18 with diagnosis of sars-cov-2-infection based on positive pcr test result and can provide informed consent diagnosed with pneumonia due to sars-cov-2 respiratory rate ≥ 25/minute and spo2 ≤ 93% review of chest radiograph, chest computed tomography (ct) scan, or chest ultrasound consistent with bilateral infiltrates. horowitz index (partial pressure of oxygen/fraction of inspired oxygen [pao2/fio2]) ≤ 300. if a subject does not have an arterial line in place, a spo2/fio2 ≤ 315 may be used.

inclusion criteria: to be considered eligible to participate in this study, the subject must meet all of the inclusion criteria listed below: hospitalized patients age ≥ 18 with diagnosis of sars-cov-2-infection based on positive pcr test result and can provide informed consent diagnosed with pneumonia due to sars-cov-2 respiratory rate ≥ 25/minute and spo2 ≤ 93% review of chest radiograph, chest computed tomography (ct) scan, or chest ultrasound consistent with bilateral infiltrates. horowitz index (partial pressure of oxygen/fraction of inspired oxygen [pao2/fio2]) ≤ 300. if a subject does not have an arterial line in place, a spo2/fio2 ≤ 315 may be used.