to be eligible for entry into the study, the subject must not meet any of the exclusion criteria listed below: * age \< 18 * pregnant or lactating women * history of heart failure * clinically significant cardiac dysrhythmia, as determined by investigator * history renal impairment * presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 2000 mm3, aspartate aminotransferase

to be eligible for entry into the study, the subject must not meet any of the exclusion criteria listed below: * age \< 18 * pregnant or lactating women * history of heart failure * clinically significant cardiac dysrhythmia, as determined by investigator * history renal impairment * presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 2000 mm3, aspartate aminotransferase

to be eligible for entry into the study, the subject must not meet any of the exclusion criteria listed below: age < 18 pregnant or lactating women history of heart failure clinically significant cardiac dysrhythmia, as determined by investigator history renal impairment presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 2000 mm3, aspartate aminotransferase

to be eligible for entry into the study, the subject must not meet any of the exclusion criteria listed below: age < 18 pregnant or lactating women history of heart failure clinically significant cardiac dysrhythmia, as determined by investigator history renal impairment presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 2000 mm3, aspartate aminotransferase