* pregnant and lactating woman * patient who are diagnosed or have history of tumor and cancer * patient whose mother or sister are diagnosed with breast or ovarian cancer * level of sgpt/alt is ≥ 5 times upper limit from normal value * level of egfr is \< 30 ml/min * reluctant to sign informed consent and unwilling to take the required tests * require invasive ventilation * shock * organ failure * currently involve in other clinical trial, or join another clinical trial in the last 3 months

* pregnant and lactating woman * patient who are diagnosed or have history of tumor and cancer * patient whose mother or sister are diagnosed with breast or ovarian cancer * level of sgpt/alt is ≥ 5 times upper limit from normal value * level of egfr is \< 30 ml/min * reluctant to sign informed consent and unwilling to take the required tests * require invasive ventilation * shock * organ failure * currently involve in other clinical trial, or join another clinical trial in the last 3 months

pregnant and lactating woman patient who are diagnosed or have history of tumor and cancer patient whose mother or sister are diagnosed with breast or ovarian cancer level of sgpt/alt is ≥ 5 times upper limit from normal value level of egfr is < 30 ml/min reluctant to sign informed consent and unwilling to take the required tests require invasive ventilation shock organ failure currently involve in other clinical trial, or join another clinical trial in the last 3 months

pregnant and lactating woman patient who are diagnosed or have history of tumor and cancer patient whose mother or sister are diagnosed with breast or ovarian cancer level of sgpt/alt is ≥ 5 times upper limit from normal value level of egfr is < 30 ml/min reluctant to sign informed consent and unwilling to take the required tests require invasive ventilation shock organ failure currently involve in other clinical trial, or join another clinical trial in the last 3 months