inclusion criteria: men and non-pregnant women over 18 years old covid diagnosis confirmed by real time polymerase chain reaction (rt-pcr) pao2 / fio2 \<200 laboratory: high sensitivity c reactive protein\> 5 mg / l; lactic dehydrogenase (ldh ) \> 245 u / l; ferritin\> 300; d-dimer\> 1500; interleukin-6\> 7.0 pg / ml.

inclusion criteria: men and non-pregnant women over 18 years old covid diagnosis confirmed by real time polymerase chain reaction (rt-pcr) pao2 / fio2 \<200 laboratory: high sensitivity c reactive protein\> 5 mg / l; lactic dehydrogenase (ldh ) \> 245 u / l; ferritin\> 300; d-dimer\> 1500; interleukin-6\> 7.0 pg / ml.

inclusion criteria: men and non-pregnant women over 18 years old covid diagnosis confirmed by real time polymerase chain reaction (rt-pcr) pao2 / fio2 <200 laboratory: high sensitivity c reactive protein> 5 mg / l; lactic dehydrogenase (ldh ) > 245 u / l; ferritin> 300; d-dimer> 1500; interleukin-6> 7.0 pg / ml.

inclusion criteria: men and non-pregnant women over 18 years old covid diagnosis confirmed by real time polymerase chain reaction (rt-pcr) pao2 / fio2 <200 laboratory: high sensitivity c reactive protein> 5 mg / l; lactic dehydrogenase (ldh ) > 245 u / l; ferritin> 300; d-dimer> 1500; interleukin-6> 7.0 pg / ml.