* the subject was pregnant or lactating. * the subject was a female at risk of pregnancy during the study and not taking adequate precautions against pregnancy. * the subject had a known hypersensitivity to any of the test materials or related compounds. * the subject was unable or unwilling to comply fully with the protocol. * treatment with investigational drug (s) within 6 months before the screening visit. * the subject had previously entered in this study. * patient who planned to schedule elective surgery during the study * the used of other antiviral agents

* the subject was pregnant or lactating. * the subject was a female at risk of pregnancy during the study and not taking adequate precautions against pregnancy. * the subject had a known hypersensitivity to any of the test materials or related compounds. * the subject was unable or unwilling to comply fully with the protocol. * treatment with investigational drug (s) within 6 months before the screening visit. * the subject had previously entered in this study. * patient who planned to schedule elective surgery during the study * the used of other antiviral agents

- the subject was pregnant or lactating. - the subject was a female at risk of pregnancy during the study and not taking adequate precautions against pregnancy. - the subject had a known hypersensitivity to any of the test materials or related compounds. - the subject was unable or unwilling to comply fully with the protocol. - treatment with investigational drug (s) within 6 months before the screening visit. - the subject had previously entered in this study. - patient who planned to schedule elective surgery during the study - the used of other antiviral agents

- the subject was pregnant or lactating. - the subject was a female at risk of pregnancy during the study and not taking adequate precautions against pregnancy. - the subject had a known hypersensitivity to any of the test materials or related compounds. - the subject was unable or unwilling to comply fully with the protocol. - treatment with investigational drug (s) within 6 months before the screening visit. - the subject had previously entered in this study. - patient who planned to schedule elective surgery during the study - the used of other antiviral agents