inclusion criteria: 1. adult patients are 18 years old or above. 2. inpatients diagnosed as severe covid - 19 disease according to who criteria. 3. ct chest with extensive lung disease (ground-glass and consolidative pulmonary opacities). 4. o2 saturation less than 93% resting. 5. respiratory rate equal or more than 30 per minute.

inclusion criteria: 1. adult patients are 18 years old or above. 2. inpatients diagnosed as severe covid - 19 disease according to who criteria. 3. ct chest with extensive lung disease (ground-glass and consolidative pulmonary opacities). 4. o2 saturation less than 93% resting. 5. respiratory rate equal or more than 30 per minute.

inclusion criteria: adult patients are 18 years old or above. inpatients diagnosed as severe covid - 19 disease according to who criteria. ct chest with extensive lung disease (ground-glass and consolidative pulmonary opacities). o2 saturation less than 93% resting. respiratory rate equal or more than 30 per minute.

inclusion criteria: adult patients are 18 years old or above. inpatients diagnosed as severe covid - 19 disease according to who criteria. ct chest with extensive lung disease (ground-glass and consolidative pulmonary opacities). o2 saturation less than 93% resting. respiratory rate equal or more than 30 per minute.

inclusion criteria: 1. adult patients are 18 years old or above. 2. inpatients diagnosed as severe covid - 19 disease according to who criteria. 3. ct chest with extensive lung disease (ground-glass and consolidative pulmonary opacities). 4. o2 saturation less than 93% resting. 5. respiratory rate equal or more than 30 per minute.

inclusion criteria: 1. adult patients are 18 years old or above. 2. inpatients diagnosed as severe covid - 19 disease according to who criteria. 3. ct chest with extensive lung disease (ground-glass and consolidative pulmonary opacities). 4. o2 saturation less than 93% resting. 5. respiratory rate equal or more than 30 per minute.