absence of affiliation to the french sociale security patient under a tutelage measure or placed under judicial protection known pregnancy currently receiving ecmo therapy chronic liver disease defined as a child-pugh score of 12-15 severe hepatic failure expected duration of mechanical ventilation <48 hours moribund patient, i.e. not expected to survive 24 hours despite intensive care burns >70% total body surface previous hypersensitivity or anaphylactic reaction to sevoflurane medical history of malignant hyperthermia medical history of liver disease attributed to previous exposure to a halogenated agent known hypersensitivity to propofol or any of its components suspected or proven intracranial hypertension tidal volume of 6 ml/kg predicted body weight (pbw) below 200 ml (as recommended by the manufacturer for the use of the anaconda-s (sedana medical, danderyd, sweden) enrollment in another interventional ards trial with direct impact on sedation and mechanical ventilation

absence of affiliation to the french sociale security patient under a tutelage measure or placed under judicial protection known pregnancy currently receiving ecmo therapy chronic liver disease defined as a child-pugh score of 12-15 severe hepatic failure expected duration of mechanical ventilation <48 hours moribund patient, i.e. not expected to survive 24 hours despite intensive care burns >70% total body surface previous hypersensitivity or anaphylactic reaction to sevoflurane medical history of malignant hyperthermia medical history of liver disease attributed to previous exposure to a halogenated agent known hypersensitivity to propofol or any of its components suspected or proven intracranial hypertension tidal volume of 6 ml/kg predicted body weight (pbw) below 200 ml (as recommended by the manufacturer for the use of the anaconda-s (sedana medical, danderyd, sweden) enrollment in another interventional ards trial with direct impact on sedation and mechanical ventilation