1. more than seven days with invasive mechanical ventilation 2. refractory shock (noradrenaline dose \> 0.5 micrograms/ kg/minute) 3. decompensated cirrhosis 4. chronic kidney disease requiring hemodialysis 5. active neoplastic disease 6. severe chronic heart failure (nyha class iii or iv) 7. severe pulmonary disease (gold iii or iv) 8. hiv infection (aids criteria)

1. more than seven days with invasive mechanical ventilation 2. refractory shock (noradrenaline dose \> 0.5 micrograms/ kg/minute) 3. decompensated cirrhosis 4. chronic kidney disease requiring hemodialysis 5. active neoplastic disease 6. severe chronic heart failure (nyha class iii or iv) 7. severe pulmonary disease (gold iii or iv) 8. hiv infection (aids criteria)

more than seven days with invasive mechanical ventilation refractory shock (noradrenaline dose > 0.5 micrograms/ kg/minute) decompensated cirrhosis chronic kidney disease requiring hemodialysis active neoplastic disease severe chronic heart failure (nyha class iii or iv) severe pulmonary disease (gold iii or iv) hiv infection (aids criteria)

more than seven days with invasive mechanical ventilation refractory shock (noradrenaline dose > 0.5 micrograms/ kg/minute) decompensated cirrhosis chronic kidney disease requiring hemodialysis active neoplastic disease severe chronic heart failure (nyha class iii or iv) severe pulmonary disease (gold iii or iv) hiv infection (aids criteria)

1. more than seven days with invasive mechanical ventilation 2. refractory shock (noradrenaline dose > 0.5 micrograms/ kg/minute) 3. decompensated cirrhosis 4. chronic kidney disease requiring hemodialysis 5. active neoplastic disease 6. severe chronic heart failure (nyha class iii or iv) 7. severe pulmonary disease (gold iii or iv) 8. hiv infection (aids criteria)

1. more than seven days with invasive mechanical ventilation 2. refractory shock (noradrenaline dose > 0.5 micrograms/ kg/minute) 3. decompensated cirrhosis 4. chronic kidney disease requiring hemodialysis 5. active neoplastic disease 6. severe chronic heart failure (nyha class iii or iv) 7. severe pulmonary disease (gold iii or iv) 8. hiv infection (aids criteria)