inclusion criteria: * 1. patients admitted with rt-pcr confirmed covid-19 illness. 2. age \> 18 years 3. written informed consent 4. has any of the two 1. pao2/ fio2 \<300 2. respiratory rate \> 24/min and sao2 \< 93% on room air or in case of severe or immediately life-threatening covid-19, for example: a. severe disease is defined as: i. dyspnea, ii. respiratory frequency ≥ 30/min, iii. blood oxygen saturation ≤ 93%, iv. partial pressure of arterial oxygen to fraction of inspired oxygen ratio \< 300, and/or v. lung infiltrates \> 50% within 24 to 48 hours b. life-threatening disease is defined as: i. respiratory failure, ii. septic shock, and/or iii. multiple organ dysfunction or failure

inclusion criteria: * 1. patients admitted with rt-pcr confirmed covid-19 illness. 2. age \> 18 years 3. written informed consent 4. has any of the two 1. pao2/ fio2 \<300 2. respiratory rate \> 24/min and sao2 \< 93% on room air or in case of severe or immediately life-threatening covid-19, for example: a. severe disease is defined as: i. dyspnea, ii. respiratory frequency ≥ 30/min, iii. blood oxygen saturation ≤ 93%, iv. partial pressure of arterial oxygen to fraction of inspired oxygen ratio \< 300, and/or v. lung infiltrates \> 50% within 24 to 48 hours b. life-threatening disease is defined as: i. respiratory failure, ii. septic shock, and/or iii. multiple organ dysfunction or failure

inclusion criteria: 1. patients admitted with rt-pcr confirmed covid-19 illness. 2. age > 18 years 3. written informed consent 4. has any of the two pao2/ fio2 <300 respiratory rate > 24/min and sao2 < 93% on room air or in case of severe or immediately life-threatening covid-19, for example: a. severe disease is defined as: i. dyspnea, ii. respiratory frequency ≥ 30/min, iii. blood oxygen saturation ≤ 93%, iv. partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300, and/or v. lung infiltrates > 50% within 24 to 48 hours b. life-threatening disease is defined as: i. respiratory failure, ii. septic shock, and/or iii. multiple organ dysfunction or failure

inclusion criteria: 1. patients admitted with rt-pcr confirmed covid-19 illness. 2. age > 18 years 3. written informed consent 4. has any of the two pao2/ fio2 <300 respiratory rate > 24/min and sao2 < 93% on room air or in case of severe or immediately life-threatening covid-19, for example: a. severe disease is defined as: i. dyspnea, ii. respiratory frequency ≥ 30/min, iii. blood oxygen saturation ≤ 93%, iv. partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300, and/or v. lung infiltrates > 50% within 24 to 48 hours b. life-threatening disease is defined as: i. respiratory failure, ii. septic shock, and/or iii. multiple organ dysfunction or failure

inclusion criteria: - 1. patients admitted with rt-pcr confirmed covid-19 illness. 2. age > 18 years 3. written informed consent 4. has any of the two 1. pao2/ fio2 <300 2. respiratory rate > 24/min and sao2 < 93% on room air or in case of severe or immediately life-threatening covid-19, for example: a. severe disease is defined as: i. dyspnea, ii. respiratory frequency ≥ 30/min, iii. blood oxygen saturation ≤ 93%, iv. partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300, and/or v. lung infiltrates > 50% within 24 to 48 hours b. life-threatening disease is defined as: i. respiratory failure, ii. septic shock, and/or iii. multiple organ dysfunction or failure

inclusion criteria: - 1. patients admitted with rt-pcr confirmed covid-19 illness. 2. age > 18 years 3. written informed consent 4. has any of the two 1. pao2/ fio2 <300 2. respiratory rate > 24/min and sao2 < 93% on room air or in case of severe or immediately life-threatening covid-19, for example: a. severe disease is defined as: i. dyspnea, ii. respiratory frequency ≥ 30/min, iii. blood oxygen saturation ≤ 93%, iv. partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300, and/or v. lung infiltrates > 50% within 24 to 48 hours b. life-threatening disease is defined as: i. respiratory failure, ii. septic shock, and/or iii. multiple organ dysfunction or failure