inclusion criteria: * - american society of anesthesiologists (asa) physical status ii- iii. * sex (male and females). * age 18 -80 years. * sever adult respiratory distress (ards) (defined as a pao2:fio2 ratio of \<150 mm hg, with a fraction of inspired oxygen (fio2) of ≥0.6, a positive end expiratory pressure (peep) of ≥5 cmh2o, and a tidal volume of 6 ml/kg of predicted body weight * mechanical ventilation for less than 36 hours

inclusion criteria: * - american society of anesthesiologists (asa) physical status ii- iii. * sex (male and females). * age 18 -80 years. * sever adult respiratory distress (ards) (defined as a pao2:fio2 ratio of \<150 mm hg, with a fraction of inspired oxygen (fio2) of ≥0.6, a positive end expiratory pressure (peep) of ≥5 cmh2o, and a tidal volume of 6 ml/kg of predicted body weight * mechanical ventilation for less than 36 hours

inclusion criteria: - - american society of anesthesiologists (asa) physical status ii- iii. - sex (male and females). - age 18 -80 years. - sever adult respiratory distress (ards) (defined as a pao2:fio2 ratio of <150 mm hg, with a fraction of inspired oxygen (fio2) of ≥0.6, a positive end expiratory pressure (peep) of ≥5 cmh2o, and a tidal volume of 6 ml/kg of predicted body weight - mechanical ventilation for less than 36 hours

inclusion criteria: - - american society of anesthesiologists (asa) physical status ii- iii. - sex (male and females). - age 18 -80 years. - sever adult respiratory distress (ards) (defined as a pao2:fio2 ratio of <150 mm hg, with a fraction of inspired oxygen (fio2) of ≥0.6, a positive end expiratory pressure (peep) of ≥5 cmh2o, and a tidal volume of 6 ml/kg of predicted body weight - mechanical ventilation for less than 36 hours

inclusion criteria: - - american society of anesthesiologists (asa) physical status ii- iii. - sex (male and females). - age 18 -80 years. - sever ards (defined as a pao2:fio2 ratio of <150 mm hg, with an fio2 of ≥0.6, a peep of ≥5 cmh2o, and a tidal volume of 6 ml/kg of predicted body weight - mechanical ventilation for less than 36 hours

inclusion criteria: - - american society of anesthesiologists (asa) physical status ii- iii. - sex (male and females). - age 18 -80 years. - sever ards (defined as a pao2:fio2 ratio of <150 mm hg, with an fio2 of ≥0.6, a peep of ≥5 cmh2o, and a tidal volume of 6 ml/kg of predicted body weight - mechanical ventilation for less than 36 hours