inclusion criteria: * adults (age over 18 yrs) of both sexes * with positive sars-cov-2 carriage by rt-pcr * having given their written consent after having been informed exclusion criteria * patient with low viral load (threshold cycle \[ct\] \> 25 per rt-pcr), * patient unable to perform oro-nasopharyngeal decolonization * known hypersensitivity to one of the constituents, particularly to povidone-iodine, * history of dysthyroidism, * known coagulopathy, * participation in another clinical trial aimed at reducing viral load in patients with sars-cov-2, * pregnant or breastfeeding women, or women of childbearing age without effective contraception * patients not covered by a social security scheme * patients with enhanced protection

inclusion criteria: * adults (age over 18 yrs) of both sexes * with positive sars-cov-2 carriage by rt-pcr * having given their written consent after having been informed exclusion criteria * patient with low viral load (threshold cycle \[ct\] \> 25 per rt-pcr), * patient unable to perform oro-nasopharyngeal decolonization * known hypersensitivity to one of the constituents, particularly to povidone-iodine, * history of dysthyroidism, * known coagulopathy, * participation in another clinical trial aimed at reducing viral load in patients with sars-cov-2, * pregnant or breastfeeding women, or women of childbearing age without effective contraception * patients not covered by a social security scheme * patients with enhanced protection

inclusion criteria: - adults (age over 18 yrs) of both sexes - with positive sars-cov-2 carriage by rt-pcr - having given their written consent after having been informed exclusion criteria - patient with low viral load (threshold cycle [ct] > 25 per rt-pcr), - patient unable to perform oro-nasopharyngeal decolonization - known hypersensitivity to one of the constituents, particularly to povidone-iodine, - history of dysthyroidism, - known coagulopathy, - participation in another clinical trial aimed at reducing viral load in patients with sars-cov-2, - pregnant or breastfeeding women, or women of childbearing age without effective contraception - patients not covered by a social security scheme - patients with enhanced protection

inclusion criteria: - adults (age over 18 yrs) of both sexes - with positive sars-cov-2 carriage by rt-pcr - having given their written consent after having been informed exclusion criteria - patient with low viral load (threshold cycle [ct] > 25 per rt-pcr), - patient unable to perform oro-nasopharyngeal decolonization - known hypersensitivity to one of the constituents, particularly to povidone-iodine, - history of dysthyroidism, - known coagulopathy, - participation in another clinical trial aimed at reducing viral load in patients with sars-cov-2, - pregnant or breastfeeding women, or women of childbearing age without effective contraception - patients not covered by a social security scheme - patients with enhanced protection