* lactose-intolerant patients * patient needing immediate hospitalization for any medical reason * patient having more than 5 days of clinical symptoms at the inclusion visit * patients with a history of allergy to tetracyclines * pregnant or lactating women * patients participating in another clinical trial * patients with photosensitive skin pathology * patients treated with anticoagulant * patients treated with oral retinoids: isotretinoin, alitretinoin, acitretin * patients treated with vitamin a patients treated with systemic antibiotics for the duration of treatment * patients treated with barbiturates, carbamazepine or phenytoin * patients with treatment that may have an effect on covid-19 infection: chloroquine, hydroxychloroquine, remdesivir, ganciclovir, acyclovir, ribavirin, lopinavir-ritonavir * patients under guardianship or trusteeship or in safeguard of justice

* lactose-intolerant patients * patient needing immediate hospitalization for any medical reason * patient having more than 5 days of clinical symptoms at the inclusion visit * patients with a history of allergy to tetracyclines * pregnant or lactating women * patients participating in another clinical trial * patients with photosensitive skin pathology * patients treated with anticoagulant * patients treated with oral retinoids: isotretinoin, alitretinoin, acitretin * patients treated with vitamin a patients treated with systemic antibiotics for the duration of treatment * patients treated with barbiturates, carbamazepine or phenytoin * patients with treatment that may have an effect on covid-19 infection: chloroquine, hydroxychloroquine, remdesivir, ganciclovir, acyclovir, ribavirin, lopinavir-ritonavir * patients under guardianship or trusteeship or in safeguard of justice

- lactose-intolerant patients - patient needing immediate hospitalization for any medical reason - patient having more than 5 days of clinical symptoms at the inclusion visit - patients with a history of allergy to tetracyclines - pregnant or lactating women - patients participating in another clinical trial - patients with photosensitive skin pathology - patients treated with anticoagulant - patients treated with oral retinoids: isotretinoin, alitretinoin, acitretin - patients treated with vitamin a patients treated with systemic antibiotics for the duration of treatment - patients treated with barbiturates, carbamazepine or phenytoin - patients with treatment that may have an effect on covid-19 infection: chloroquine, hydroxychloroquine, remdesivir, ganciclovir, acyclovir, ribavirin, lopinavir-ritonavir - patients under guardianship or trusteeship or in safeguard of justice

- lactose-intolerant patients - patient needing immediate hospitalization for any medical reason - patient having more than 5 days of clinical symptoms at the inclusion visit - patients with a history of allergy to tetracyclines - pregnant or lactating women - patients participating in another clinical trial - patients with photosensitive skin pathology - patients treated with anticoagulant - patients treated with oral retinoids: isotretinoin, alitretinoin, acitretin - patients treated with vitamin a patients treated with systemic antibiotics for the duration of treatment - patients treated with barbiturates, carbamazepine or phenytoin - patients with treatment that may have an effect on covid-19 infection: chloroquine, hydroxychloroquine, remdesivir, ganciclovir, acyclovir, ribavirin, lopinavir-ritonavir - patients under guardianship or trusteeship or in safeguard of justice