1. inability to give consent; 2. non-fluency in english; 3. inability to adhere to the protocol; 4. anticipated life expectancy of less than six months; 5. lack of a primary care physician or treating neurologist; 6. taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; 7. presence of another autoimmune condition requiring treatment; 8. active treatment for cancer; 9. history of heavy alcohol use within the past year, as defined by the following criteria: 1. men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; 2. women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; 10. history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; 11. any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results. 12. anaphylactic or other severe reaction to a previously administered covid-19 vaccine; 13. ms relapse or worsening symptoms after initial covid-19 vaccination. 14. positive urine pregnancy test at screening \[women only\]. test is waived in women who are post-menopausal or incapable of conception.

1. inability to give consent; 2. non-fluency in english; 3. inability to adhere to the protocol; 4. anticipated life expectancy of less than six months; 5. lack of a primary care physician or treating neurologist; 6. taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; 7. presence of another autoimmune condition requiring treatment; 8. active treatment for cancer; 9. history of heavy alcohol use within the past year, as defined by the following criteria: 1. men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; 2. women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; 10. history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; 11. any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results. 12. anaphylactic or other severe reaction to a previously administered covid-19 vaccine; 13. ms relapse or worsening symptoms after initial covid-19 vaccination. 14. positive urine pregnancy test at screening \[women only\]. test is waived in women who are post-menopausal or incapable of conception.

inability to give consent; non-fluency in english; inability to adhere to the protocol; anticipated life expectancy of less than six months; lack of a primary care physician or treating neurologist; taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; presence of another autoimmune condition requiring treatment; active treatment for cancer; history of heavy alcohol use within the past year, as defined by the following criteria: men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results. anaphylactic or other severe reaction to a previously administered covid-19 vaccine; ms relapse or worsening symptoms after initial covid-19 vaccination. positive urine pregnancy test at screening [women only]. test is waived in women who are post-menopausal or incapable of conception.

inability to give consent; non-fluency in english; inability to adhere to the protocol; anticipated life expectancy of less than six months; lack of a primary care physician or treating neurologist; taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; presence of another autoimmune condition requiring treatment; active treatment for cancer; history of heavy alcohol use within the past year, as defined by the following criteria: men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results. anaphylactic or other severe reaction to a previously administered covid-19 vaccine; ms relapse or worsening symptoms after initial covid-19 vaccination. positive urine pregnancy test at screening [women only]. test is waived in women who are post-menopausal or incapable of conception.

inability to give consent; non-fluency in english; inability to adhere to the protocol; anticipated life expectancy of less than six months; lack of a primary care physician or treating neurologist; taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; presence of another autoimmune condition requiring treatment; active treatment for cancer; history of heavy alcohol use within the past year, as defined by the following criteria: men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results.anaphylactic or other severe reaction to a previously administered covid-19 vaccine; positive urine pregnancy test at screening. test is waived in women who are post-menopausal or incapable of conception.

inability to give consent; non-fluency in english; inability to adhere to the protocol; anticipated life expectancy of less than six months; lack of a primary care physician or treating neurologist; taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; presence of another autoimmune condition requiring treatment; active treatment for cancer; history of heavy alcohol use within the past year, as defined by the following criteria: men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results.anaphylactic or other severe reaction to a previously administered covid-19 vaccine; positive urine pregnancy test at screening. test is waived in women who are post-menopausal or incapable of conception.

1. inability to give consent; 2. non-fluency in english; 3. inability to adhere to the protocol; 4. anticipated life expectancy of less than six months; 5. lack of a primary care physician or treating neurologist; 6. taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; 7. presence of another autoimmune condition requiring treatment; 8. active treatment for cancer; 9. history of heavy alcohol use within the past year, as defined by the following criteria: 1. men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; 2. women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; 10. history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; 11. any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results.anaphylactic or other severe reaction to a previously administered covid-19 vaccine; 12. positive urine pregnancy test at screening. test is waived in women who are post-menopausal or incapable of conception.

1. inability to give consent; 2. non-fluency in english; 3. inability to adhere to the protocol; 4. anticipated life expectancy of less than six months; 5. lack of a primary care physician or treating neurologist; 6. taking an immunosuppressive medication or chemotherapy for any other conditions aside fromms; 7. presence of another autoimmune condition requiring treatment; 8. active treatment for cancer; 9. history of heavy alcohol use within the past year, as defined by the following criteria: 1. men: 5 or more alcoholic beverages per session or per day, or 15 or more per week; 2. women: 4 or more alcoholic beverages per session or per day, or 8 or more per week; 10. history of illicit drug abuse, e.g., cocaine, heroin, pcp, and/or narcotics within the past year; 11. any condition that would jeopardize the safety or rights of the subject, make it unlikely for the subject to complete the study, or confound the study results.anaphylactic or other severe reaction to a previously administered covid-19 vaccine; 12. positive urine pregnancy test at screening. test is waived in women who are post-menopausal or incapable of conception.