inclusion criteria: * inclusion criteria : * adult aged 18 to 75 years old * taken into primary health care for suspicion of early-stage covid-19 infection (maximum 5 days of evolution). the patient must have presented within the previous 5 days at least one of the following criteria: fever (≥38°c), cough, anosmia, agueusia, diarrhea, headache, myalgia. criteria for randomization at d2 : * positive pcr on deep nasopharyngeal swab. * kalemia ≥ 3.5 mmol/l * normal magnesium and calcium levels (according to laboratory standards) * qtc ≤ 460ms for women or qtc ≤ 450ms for men * beta-hcg negative exclusion criteria : * comorbidity(ies) or clinical condition of the patient requiring immediate oxygen therapy, hospitalization and/or ventilatory assistance * concomitant treatment contraindicated, not recommended, or with precautions for use in combination with hydroxychloroquine or azithromycin: * drug likely to induce torsades de pointe or at increased risk of ventricular arrhythmia, and in particular citalopram, escitalopram, hydroxyzine, domperidone, piperazine, class ia and iii antiarrhythmics, tricyclic antidepressants, antipsychotics and certain anti-infectives (macrolides, fluoroquinolones). * alkaloids of ergot of rye, colchicine, cisapride * proconvulsant or epileptogenic threshold lowering drugs: imipraminic antidepressants, selective serotonin reuptake inhibitors, neuroleptics (phenothiazines and butyrophenones) and tramadol. * known history of contraindications or increased risk of treatment with hydroxychloroquine or azithromycin (retinopathy,renal failure, significant liver failure, severe cholestasis, porphyria, known g6pd deficit, hypomagnesemia and hypokalemia, diabetes, myasthenia gravis, heart diseases (heart failure, infarction, arrhythmia, congenital qtc prolongation, abnormalities that interfere with qtc measurement such as left bundle branch block, right bundle branch block, pace maker with ventricular pacing), epilepsy, allergy to hydroxychloroquine, chloroquine, azithromycin, erythromycin, any other macrolide, ketolide or any of the excipients of plaquenil® or zithromax® or any of the components of azinc form and vitality®. * ongoing treatment with hydroxychloroquine or azithromycin, regardless of the indication. * taking other antiviral targeted therapy used in covid-19 disease * women who are pregnant or breastfeeding or planning to become pregnant within 8 months of discontinuing hydroxychloroquine therapy. * no national health insurrance (sécurité sociale, cmu or ame) coverage. * major under guardianship or curatorship * participation in another therapeutic clinical trial for covid-19 * refusal to participate in the study and/or lack of signature of a consent

inclusion criteria: * inclusion criteria : * adult aged 18 to 75 years old * taken into primary health care for suspicion of early-stage covid-19 infection (maximum 5 days of evolution). the patient must have presented within the previous 5 days at least one of the following criteria: fever (≥38°c), cough, anosmia, agueusia, diarrhea, headache, myalgia. criteria for randomization at d2 : * positive pcr on deep nasopharyngeal swab. * kalemia ≥ 3.5 mmol/l * normal magnesium and calcium levels (according to laboratory standards) * qtc ≤ 460ms for women or qtc ≤ 450ms for men * beta-hcg negative exclusion criteria : * comorbidity(ies) or clinical condition of the patient requiring immediate oxygen therapy, hospitalization and/or ventilatory assistance * concomitant treatment contraindicated, not recommended, or with precautions for use in combination with hydroxychloroquine or azithromycin: * drug likely to induce torsades de pointe or at increased risk of ventricular arrhythmia, and in particular citalopram, escitalopram, hydroxyzine, domperidone, piperazine, class ia and iii antiarrhythmics, tricyclic antidepressants, antipsychotics and certain anti-infectives (macrolides, fluoroquinolones). * alkaloids of ergot of rye, colchicine, cisapride * proconvulsant or epileptogenic threshold lowering drugs: imipraminic antidepressants, selective serotonin reuptake inhibitors, neuroleptics (phenothiazines and butyrophenones) and tramadol. * known history of contraindications or increased risk of treatment with hydroxychloroquine or azithromycin (retinopathy,renal failure, significant liver failure, severe cholestasis, porphyria, known g6pd deficit, hypomagnesemia and hypokalemia, diabetes, myasthenia gravis, heart diseases (heart failure, infarction, arrhythmia, congenital qtc prolongation, abnormalities that interfere with qtc measurement such as left bundle branch block, right bundle branch block, pace maker with ventricular pacing), epilepsy, allergy to hydroxychloroquine, chloroquine, azithromycin, erythromycin, any other macrolide, ketolide or any of the excipients of plaquenil® or zithromax® or any of the components of azinc form and vitality®. * ongoing treatment with hydroxychloroquine or azithromycin, regardless of the indication. * taking other antiviral targeted therapy used in covid-19 disease * women who are pregnant or breastfeeding or planning to become pregnant within 8 months of discontinuing hydroxychloroquine therapy. * no national health insurrance (sécurité sociale, cmu or ame) coverage. * major under guardianship or curatorship * participation in another therapeutic clinical trial for covid-19 * refusal to participate in the study and/or lack of signature of a consent

inclusion criteria: - inclusion criteria : - adult aged 18 to 75 years old - taken into primary health care for suspicion of early-stage covid-19 infection (maximum 5 days of evolution). the patient must have presented within the previous 5 days at least one of the following criteria: fever (≥38°c), cough, anosmia, agueusia, diarrhea, headache, myalgia. criteria for randomization at d2 : - positive pcr on deep nasopharyngeal swab. - kalemia ≥ 3.5 mmol/l - normal magnesium and calcium levels (according to laboratory standards) - qtc ≤ 460ms for women or qtc ≤ 450ms for men - beta-hcg negative exclusion criteria : - comorbidity(ies) or clinical condition of the patient requiring immediate oxygen therapy, hospitalization and/or ventilatory assistance - concomitant treatment contraindicated, not recommended, or with precautions for use in combination with hydroxychloroquine or azithromycin: - drug likely to induce torsades de pointe or at increased risk of ventricular arrhythmia, and in particular citalopram, escitalopram, hydroxyzine, domperidone, piperazine, class ia and iii antiarrhythmics, tricyclic antidepressants, antipsychotics and certain anti-infectives (macrolides, fluoroquinolones). - alkaloids of ergot of rye, colchicine, cisapride - proconvulsant or epileptogenic threshold lowering drugs: imipraminic antidepressants, selective serotonin reuptake inhibitors, neuroleptics (phenothiazines and butyrophenones) and tramadol. - known history of contraindications or increased risk of treatment with hydroxychloroquine or azithromycin (retinopathy,renal failure, significant liver failure, severe cholestasis, porphyria, known g6pd deficit, hypomagnesemia and hypokalemia, diabetes, myasthenia gravis, heart diseases (heart failure, infarction, arrhythmia, congenital qtc prolongation, abnormalities that interfere with qtc measurement such as left bundle branch block, right bundle branch block, pace maker with ventricular pacing), epilepsy, allergy to hydroxychloroquine, chloroquine, azithromycin, erythromycin, any other macrolide, ketolide or any of the excipients of plaquenil® or zithromax® or any of the components of azinc form and vitality®. - ongoing treatment with hydroxychloroquine or azithromycin, regardless of the indication. - taking other antiviral targeted therapy used in covid-19 disease - women who are pregnant or breastfeeding or planning to become pregnant within 8 months of discontinuing hydroxychloroquine therapy. - no national health insurrance (sécurité sociale, cmu or ame) coverage. - major under guardianship or curatorship - participation in another therapeutic clinical trial for covid-19 - refusal to participate in the study and/or lack of signature of a consent

inclusion criteria: - inclusion criteria : - adult aged 18 to 75 years old - taken into primary health care for suspicion of early-stage covid-19 infection (maximum 5 days of evolution). the patient must have presented within the previous 5 days at least one of the following criteria: fever (≥38°c), cough, anosmia, agueusia, diarrhea, headache, myalgia. criteria for randomization at d2 : - positive pcr on deep nasopharyngeal swab. - kalemia ≥ 3.5 mmol/l - normal magnesium and calcium levels (according to laboratory standards) - qtc ≤ 460ms for women or qtc ≤ 450ms for men - beta-hcg negative exclusion criteria : - comorbidity(ies) or clinical condition of the patient requiring immediate oxygen therapy, hospitalization and/or ventilatory assistance - concomitant treatment contraindicated, not recommended, or with precautions for use in combination with hydroxychloroquine or azithromycin: - drug likely to induce torsades de pointe or at increased risk of ventricular arrhythmia, and in particular citalopram, escitalopram, hydroxyzine, domperidone, piperazine, class ia and iii antiarrhythmics, tricyclic antidepressants, antipsychotics and certain anti-infectives (macrolides, fluoroquinolones). - alkaloids of ergot of rye, colchicine, cisapride - proconvulsant or epileptogenic threshold lowering drugs: imipraminic antidepressants, selective serotonin reuptake inhibitors, neuroleptics (phenothiazines and butyrophenones) and tramadol. - known history of contraindications or increased risk of treatment with hydroxychloroquine or azithromycin (retinopathy,renal failure, significant liver failure, severe cholestasis, porphyria, known g6pd deficit, hypomagnesemia and hypokalemia, diabetes, myasthenia gravis, heart diseases (heart failure, infarction, arrhythmia, congenital qtc prolongation, abnormalities that interfere with qtc measurement such as left bundle branch block, right bundle branch block, pace maker with ventricular pacing), epilepsy, allergy to hydroxychloroquine, chloroquine, azithromycin, erythromycin, any other macrolide, ketolide or any of the excipients of plaquenil® or zithromax® or any of the components of azinc form and vitality®. - ongoing treatment with hydroxychloroquine or azithromycin, regardless of the indication. - taking other antiviral targeted therapy used in covid-19 disease - women who are pregnant or breastfeeding or planning to become pregnant within 8 months of discontinuing hydroxychloroquine therapy. - no national health insurrance (sécurité sociale, cmu or ame) coverage. - major under guardianship or curatorship - participation in another therapeutic clinical trial for covid-19 - refusal to participate in the study and/or lack of signature of a consent