1. the presence of contraindications to vaccination: * hypersensitivity to any component of the vaccine or a vaccine containing similar components; * prior history of severe allergic reactions; * acute infectious and non-infectious diseases, exacerbation of chronic diseases. 2. severe chronic hepatic and renal disorders, severe thyroid dysfunction, decompensated diabetes mellitus, severe disorders of the hematopoietic system, epilepsy and other cns diseases, acute coronary syndrome, acute cerebrovascular accident, myocarditis, endocarditis, pericarditis, autoimmune diseases, or immunodeficiency. 3. malabsorption syndrome, including congenital or acquired lactase deficiency or any other disaccharidase deficiency, galactosemia. 4. hypersensitivity to any of the components of study drug used in the treatment. 5. pregnancy, breast-feeding, childbirth less than 3 months before study enrollment. 6. participants who, from the investigator's point of view, will not comply with study observation requirements or study drug administration procedures. 7. inability to observe the participant during the study period. 8. prior history of mental illness, alcoholism or drug abuse, that the investigator's opinion, will interfere with successful study procedures. 9. participation in other clinical studies within 3 months prior to enrollment in the study. 10. use of any medications listed in "prohibited concomitant treatment" within 4 weeks before enrollment. 11. participants who are related to any of the on-site research personnel directly involved in the conduct of the trial or are an immediate relative of the study investigator. "immediate relative" means husband, wife, parent, son, daughter, brother, or sister (regardless of whether they are natural or adopted). 12. participants who work for ooo "npf "materia medica holding" (i.e. the company's employees, temporary contract workers, designated officials responsible for carrying out the research or any immediate relatives of the aforementioned).

1. the presence of contraindications to vaccination: * hypersensitivity to any component of the vaccine or a vaccine containing similar components; * prior history of severe allergic reactions; * acute infectious and non-infectious diseases, exacerbation of chronic diseases. 2. severe chronic hepatic and renal disorders, severe thyroid dysfunction, decompensated diabetes mellitus, severe disorders of the hematopoietic system, epilepsy and other cns diseases, acute coronary syndrome, acute cerebrovascular accident, myocarditis, endocarditis, pericarditis, autoimmune diseases, or immunodeficiency. 3. malabsorption syndrome, including congenital or acquired lactase deficiency or any other disaccharidase deficiency, galactosemia. 4. hypersensitivity to any of the components of study drug used in the treatment. 5. pregnancy, breast-feeding, childbirth less than 3 months before study enrollment. 6. participants who, from the investigator's point of view, will not comply with study observation requirements or study drug administration procedures. 7. inability to observe the participant during the study period. 8. prior history of mental illness, alcoholism or drug abuse, that the investigator's opinion, will interfere with successful study procedures. 9. participation in other clinical studies within 3 months prior to enrollment in the study. 10. use of any medications listed in "prohibited concomitant treatment" within 4 weeks before enrollment. 11. participants who are related to any of the on-site research personnel directly involved in the conduct of the trial or are an immediate relative of the study investigator. "immediate relative" means husband, wife, parent, son, daughter, brother, or sister (regardless of whether they are natural or adopted). 12. participants who work for ooo "npf "materia medica holding" (i.e. the company's employees, temporary contract workers, designated officials responsible for carrying out the research or any immediate relatives of the aforementioned).

the presence of contraindications to vaccination: hypersensitivity to any component of the vaccine or a vaccine containing similar components; prior history of severe allergic reactions; acute infectious and non-infectious diseases, exacerbation of chronic diseases. severe chronic hepatic and renal disorders, severe thyroid dysfunction, decompensated diabetes mellitus, severe disorders of the hematopoietic system, epilepsy and other cns diseases, acute coronary syndrome, acute cerebrovascular accident, myocarditis, endocarditis, pericarditis, autoimmune diseases, or immunodeficiency. malabsorption syndrome, including congenital or acquired lactase deficiency or any other disaccharidase deficiency, galactosemia. hypersensitivity to any of the components of study drug used in the treatment. pregnancy, breast-feeding, childbirth less than 3 months before study enrollment. participants who, from the investigator's point of view, will not comply with study observation requirements or study drug administration procedures. inability to observe the participant during the study period. prior history of mental illness, alcoholism or drug abuse, that the investigator's opinion, will interfere with successful study procedures. participation in other clinical studies within 3 months prior to enrollment in the study. use of any medications listed in "prohibited concomitant treatment" within 4 weeks before enrollment. participants who are related to any of the on-site research personnel directly involved in the conduct of the trial or are an immediate relative of the study investigator. "immediate relative" means husband, wife, parent, son, daughter, brother, or sister (regardless of whether they are natural or adopted). participants who work for ooo "npf "materia medica holding" (i.e. the company's employees, temporary contract workers, designated officials responsible for carrying out the research or any immediate relatives of the aforementioned).

the presence of contraindications to vaccination: hypersensitivity to any component of the vaccine or a vaccine containing similar components; prior history of severe allergic reactions; acute infectious and non-infectious diseases, exacerbation of chronic diseases. severe chronic hepatic and renal disorders, severe thyroid dysfunction, decompensated diabetes mellitus, severe disorders of the hematopoietic system, epilepsy and other cns diseases, acute coronary syndrome, acute cerebrovascular accident, myocarditis, endocarditis, pericarditis, autoimmune diseases, or immunodeficiency. malabsorption syndrome, including congenital or acquired lactase deficiency or any other disaccharidase deficiency, galactosemia. hypersensitivity to any of the components of study drug used in the treatment. pregnancy, breast-feeding, childbirth less than 3 months before study enrollment. participants who, from the investigator's point of view, will not comply with study observation requirements or study drug administration procedures. inability to observe the participant during the study period. prior history of mental illness, alcoholism or drug abuse, that the investigator's opinion, will interfere with successful study procedures. participation in other clinical studies within 3 months prior to enrollment in the study. use of any medications listed in "prohibited concomitant treatment" within 4 weeks before enrollment. participants who are related to any of the on-site research personnel directly involved in the conduct of the trial or are an immediate relative of the study investigator. "immediate relative" means husband, wife, parent, son, daughter, brother, or sister (regardless of whether they are natural or adopted). participants who work for ooo "npf "materia medica holding" (i.e. the company's employees, temporary contract workers, designated officials responsible for carrying out the research or any immediate relatives of the aforementioned).

1. the presence of contraindications to vaccination: - hypersensitivity to any component of the vaccine or a vaccine containing similar components; - prior history of severe allergic reactions; - acute infectious and non-infectious diseases, exacerbation of chronic diseases. 2. severe chronic hepatic and renal disorders, severe thyroid dysfunction, decompensated diabetes mellitus, severe disorders of the hematopoietic system, epilepsy and other cns diseases, acute coronary syndrome, acute cerebrovascular accident, myocarditis, endocarditis, pericarditis, autoimmune diseases, or immunodeficiency. 3. malabsorption syndrome, including congenital or acquired lactase deficiency or any other disaccharidase deficiency, galactosemia. 4. hypersensitivity to any of the components of study drug used in the treatment. 5. pregnancy, breast-feeding, childbirth less than 3 months before study enrollment. 6. participants who, from the investigator's point of view, will not comply with study observation requirements or study drug administration procedures. 7. inability to observe the participant during the study period. 8. prior history of mental illness, alcoholism or drug abuse, that the investigator's opinion, will interfere with successful study procedures. 9. participation in other clinical studies within 3 months prior to enrollment in the study. 10. use of any medications listed in "prohibited concomitant treatment" within 4 weeks before enrollment. 11. participants who are related to any of the on-site research personnel directly involved in the conduct of the trial or are an immediate relative of the study investigator. "immediate relative" means husband, wife, parent, son, daughter, brother, or sister (regardless of whether they are natural or adopted). 12. participants who work for ooo "npf "materia medica holding" (i.e. the company's employees, temporary contract workers, designated officials responsible for carrying out the research or any immediate relatives of the aforementioned).

1. the presence of contraindications to vaccination: - hypersensitivity to any component of the vaccine or a vaccine containing similar components; - prior history of severe allergic reactions; - acute infectious and non-infectious diseases, exacerbation of chronic diseases. 2. severe chronic hepatic and renal disorders, severe thyroid dysfunction, decompensated diabetes mellitus, severe disorders of the hematopoietic system, epilepsy and other cns diseases, acute coronary syndrome, acute cerebrovascular accident, myocarditis, endocarditis, pericarditis, autoimmune diseases, or immunodeficiency. 3. malabsorption syndrome, including congenital or acquired lactase deficiency or any other disaccharidase deficiency, galactosemia. 4. hypersensitivity to any of the components of study drug used in the treatment. 5. pregnancy, breast-feeding, childbirth less than 3 months before study enrollment. 6. participants who, from the investigator's point of view, will not comply with study observation requirements or study drug administration procedures. 7. inability to observe the participant during the study period. 8. prior history of mental illness, alcoholism or drug abuse, that the investigator's opinion, will interfere with successful study procedures. 9. participation in other clinical studies within 3 months prior to enrollment in the study. 10. use of any medications listed in "prohibited concomitant treatment" within 4 weeks before enrollment. 11. participants who are related to any of the on-site research personnel directly involved in the conduct of the trial or are an immediate relative of the study investigator. "immediate relative" means husband, wife, parent, son, daughter, brother, or sister (regardless of whether they are natural or adopted). 12. participants who work for ooo "npf "materia medica holding" (i.e. the company's employees, temporary contract workers, designated officials responsible for carrying out the research or any immediate relatives of the aforementioned).