inclusion criteria: 1. subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. 2. understands and agrees to comply with planned study procedures. 3. male or non-pregnant female adult ≥18 years of age at time of enrollment. 4. subject consents to randomization within 36 hours of hospital admission. 5. has radiographic confirmed covid-19 disease \< 72 hours prior to randomization. 6. illness of any duration, and at least one of the following: * radiographic infiltrates by imaging (chest x-ray, ct scan, etc.), or * clinical assessment (evidence of rales/crackles on exam) and spo2 ≤ 94% on room air, or * requiring mechanical ventilation and/or supplemental oxygen. 7. subjects do not require laboratory confirmation of the corona virus sars-cov-2 to determine eligibility 8. women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study (acceptable methods will be determined by the site).

inclusion criteria: 1. subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. 2. understands and agrees to comply with planned study procedures. 3. male or non-pregnant female adult ≥18 years of age at time of enrollment. 4. subject consents to randomization within 36 hours of hospital admission. 5. has radiographic confirmed covid-19 disease \< 72 hours prior to randomization. 6. illness of any duration, and at least one of the following: * radiographic infiltrates by imaging (chest x-ray, ct scan, etc.), or * clinical assessment (evidence of rales/crackles on exam) and spo2 ≤ 94% on room air, or * requiring mechanical ventilation and/or supplemental oxygen. 7. subjects do not require laboratory confirmation of the corona virus sars-cov-2 to determine eligibility 8. women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study (acceptable methods will be determined by the site).

inclusion criteria: subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. understands and agrees to comply with planned study procedures. male or non-pregnant female adult ≥18 years of age at time of enrollment. subject consents to randomization within 36 hours of hospital admission. has radiographic confirmed covid-19 disease < 72 hours prior to randomization. illness of any duration, and at least one of the following: radiographic infiltrates by imaging (chest x-ray, ct scan, etc.), or clinical assessment (evidence of rales/crackles on exam) and spo2 ≤ 94% on room air, or requiring mechanical ventilation and/or supplemental oxygen. subjects do not require laboratory confirmation of the corona virus sars-cov-2 to determine eligibility women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study (acceptable methods will be determined by the site).

inclusion criteria: subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. understands and agrees to comply with planned study procedures. male or non-pregnant female adult ≥18 years of age at time of enrollment. subject consents to randomization within 36 hours of hospital admission. has radiographic confirmed covid-19 disease < 72 hours prior to randomization. illness of any duration, and at least one of the following: radiographic infiltrates by imaging (chest x-ray, ct scan, etc.), or clinical assessment (evidence of rales/crackles on exam) and spo2 ≤ 94% on room air, or requiring mechanical ventilation and/or supplemental oxygen. subjects do not require laboratory confirmation of the corona virus sars-cov-2 to determine eligibility women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study (acceptable methods will be determined by the site).

inclusion criteria: 1. subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. 2. understands and agrees to comply with planned study procedures. 3. male or non-pregnant female adult ≥18 years of age at time of enrollment. 4. subject consents to randomization within 36 hours of hospital admission. 5. has radiographic confirmed covid-19 disease < 72 hours prior to randomization. 6. illness of any duration, and at least one of the following: - radiographic infiltrates by imaging (chest x-ray, ct scan, etc.), or - clinical assessment (evidence of rales/crackles on exam) and spo2 ≤ 94% on room air, or - requiring mechanical ventilation and/or supplemental oxygen. 7. subjects do not require laboratory confirmation of the corona virus sars-cov-2 to determine eligibility 8. women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study (acceptable methods will be determined by the site).

inclusion criteria: 1. subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures. 2. understands and agrees to comply with planned study procedures. 3. male or non-pregnant female adult ≥18 years of age at time of enrollment. 4. subject consents to randomization within 36 hours of hospital admission. 5. has radiographic confirmed covid-19 disease < 72 hours prior to randomization. 6. illness of any duration, and at least one of the following: - radiographic infiltrates by imaging (chest x-ray, ct scan, etc.), or - clinical assessment (evidence of rales/crackles on exam) and spo2 ≤ 94% on room air, or - requiring mechanical ventilation and/or supplemental oxygen. 7. subjects do not require laboratory confirmation of the corona virus sars-cov-2 to determine eligibility 8. women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study (acceptable methods will be determined by the site).