inclusion criteria: * male and female subjects must be 18 - 49 years of age at screening visit. * subjects must have a body mass index \< 35 kg/m2 at screening visit. * subjects must be in good general health prior to study participation. note: subjects with a pre-existing chronic disease will be allowed to participate if the disease is stable and the condition is unlikely to confound the results of the study or pose additional risk to the subject. * female subjects of childbearing potential must have a negative urine pregnancy test result prior to vaccination. * female subjects of childbearing potential must use a highly effective method of contraception starting one month prior to vaccination, continuing until the end of the study, and must not plan to become pregnant for at least one month after her last study vaccination.

inclusion criteria: * male and female subjects must be 18 - 49 years of age at screening visit. * subjects must have a body mass index \< 35 kg/m2 at screening visit. * subjects must be in good general health prior to study participation. note: subjects with a pre-existing chronic disease will be allowed to participate if the disease is stable and the condition is unlikely to confound the results of the study or pose additional risk to the subject. * female subjects of childbearing potential must have a negative urine pregnancy test result prior to vaccination. * female subjects of childbearing potential must use a highly effective method of contraception starting one month prior to vaccination, continuing until the end of the study, and must not plan to become pregnant for at least one month after her last study vaccination.

inclusion criteria: - male and female subjects must be 18 - 49 years of age at screening visit. - subjects must have a body mass index < 35 kg/m2 at screening visit. - subjects must be in good general health prior to study participation. note: subjects with a pre-existing chronic disease will be allowed to participate if the disease is stable and the condition is unlikely to confound the results of the study or pose additional risk to the subject. - female subjects of childbearing potential must have a negative urine pregnancy test result prior to vaccination. - female subjects of childbearing potential must use a highly effective method of contraception starting one month prior to vaccination, continuing until the end of the study, and must not plan to become pregnant for at least one month after her last study vaccination.

inclusion criteria: - male and female subjects must be 18 - 49 years of age at screening visit. - subjects must have a body mass index < 35 kg/m2 at screening visit. - subjects must be in good general health prior to study participation. note: subjects with a pre-existing chronic disease will be allowed to participate if the disease is stable and the condition is unlikely to confound the results of the study or pose additional risk to the subject. - female subjects of childbearing potential must have a negative urine pregnancy test result prior to vaccination. - female subjects of childbearing potential must use a highly effective method of contraception starting one month prior to vaccination, continuing until the end of the study, and must not plan to become pregnant for at least one month after her last study vaccination.