inclusion criteria: * age above 18 years. * male and female * must understand and voluntarily sign an informed consent for study participation obtained prior to undergoing any study-specific procedures * diagnosed as covid-19 based upon sars-cov-2 rt-pcr test positive * clinical diagnosis meets severe and/or critical parameters * male participants must be willing to ensure their partners do not become pregnant either by practicing abstinence or the use of condoms during sexual activity

inclusion criteria: * age above 18 years. * male and female * must understand and voluntarily sign an informed consent for study participation obtained prior to undergoing any study-specific procedures * diagnosed as covid-19 based upon sars-cov-2 rt-pcr test positive * clinical diagnosis meets severe and/or critical parameters * male participants must be willing to ensure their partners do not become pregnant either by practicing abstinence or the use of condoms during sexual activity

inclusion criteria: - age above 18 years. - male and female - must understand and voluntarily sign an informed consent for study participation obtained prior to undergoing any study-specific procedures - diagnosed as covid-19 based upon sars-cov-2 rt-pcr test positive - clinical diagnosis meets severe and/or critical parameters - male participants must be willing to ensure their partners do not become pregnant either by practicing abstinence or the use of condoms during sexual activity

inclusion criteria: - age above 18 years. - male and female - must understand and voluntarily sign an informed consent for study participation obtained prior to undergoing any study-specific procedures - diagnosed as covid-19 based upon sars-cov-2 rt-pcr test positive - clinical diagnosis meets severe and/or critical parameters - male participants must be willing to ensure their partners do not become pregnant either by practicing abstinence or the use of condoms during sexual activity