* pregnancy * participation in other vaccine trial * active decompensated chronic condition, namely, cardiovascular, respiratory, neurological, metabolic or hepatic diseases * any immunocompromise condition (primary immunodeficiencies, auto-immune diseases, long-term use of corticosteroids, solid organ transplant recipients, hematopoietic stem-cell transplant recipients, human-immunodeficiency virus active infection) * active cancer * hepatitis b or c * history of allergic reactions to any vaccine component, including excipients and preservatives (neomycin, streptomycin, polymyxin b, eggs * blood donation in the past 4 weeks before screening * received blood product in the past 3 months before screening

* pregnancy * participation in other vaccine trial * active decompensated chronic condition, namely, cardiovascular, respiratory, neurological, metabolic or hepatic diseases * any immunocompromise condition (primary immunodeficiencies, auto-immune diseases, long-term use of corticosteroids, solid organ transplant recipients, hematopoietic stem-cell transplant recipients, human-immunodeficiency virus active infection) * active cancer * hepatitis b or c * history of allergic reactions to any vaccine component, including excipients and preservatives (neomycin, streptomycin, polymyxin b, eggs * blood donation in the past 4 weeks before screening * received blood product in the past 3 months before screening

- pregnancy - participation in other vaccine trial - active decompensated chronic condition, namely, cardiovascular, respiratory, neurological, metabolic or hepatic diseases - any immunocompromise condition (primary immunodeficiencies, auto-immune diseases, long-term use of corticosteroids, solid organ transplant recipients, hematopoietic stem-cell transplant recipients, human-immunodeficiency virus active infection) - active cancer - hepatitis b or c - history of allergic reactions to any vaccine component, including excipients and preservatives (neomycin, streptomycin, polymyxin b, eggs - blood donation in the past 4 weeks before screening - received blood product in the past 3 months before screening

- pregnancy - participation in other vaccine trial - active decompensated chronic condition, namely, cardiovascular, respiratory, neurological, metabolic or hepatic diseases - any immunocompromise condition (primary immunodeficiencies, auto-immune diseases, long-term use of corticosteroids, solid organ transplant recipients, hematopoietic stem-cell transplant recipients, human-immunodeficiency virus active infection) - active cancer - hepatitis b or c - history of allergic reactions to any vaccine component, including excipients and preservatives (neomycin, streptomycin, polymyxin b, eggs - blood donation in the past 4 weeks before screening - received blood product in the past 3 months before screening