inclusion criteria: 1. male or female participant aged 18 years and above at randomization. 2. healthy adults or adults with pre-existing medical conditions who are in stable condition. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease 3 months before enrollment and expected to remain stable for the duration of the study. 3. female participants: 1. a female participant is eligible is the participant is a woman of non-childbearing potential, ie, surgically sterilized or one year post-menopausal. 2. if the participant is a woman of childbearing potential, she must agree to practice sexual abstinence or agree to use medically effective contraception from 14 days before screening to 30 days following the last administration of study intervention. 3. have a negative pregnancy test 4. participant is willing and able to comply with all required study visits and follow-up required by this protocol. 5. participant or the participant's legal representative must understand the procedures of the study and provide written informed consent.

inclusion criteria: 1. male or female participant aged 18 years and above at randomization. 2. healthy adults or adults with pre-existing medical conditions who are in stable condition. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease 3 months before enrollment and expected to remain stable for the duration of the study. 3. female participants: 1. a female participant is eligible is the participant is a woman of non-childbearing potential, ie, surgically sterilized or one year post-menopausal. 2. if the participant is a woman of childbearing potential, she must agree to practice sexual abstinence or agree to use medically effective contraception from 14 days before screening to 30 days following the last administration of study intervention. 3. have a negative pregnancy test 4. participant is willing and able to comply with all required study visits and follow-up required by this protocol. 5. participant or the participant's legal representative must understand the procedures of the study and provide written informed consent.

inclusion criteria: male or female participant aged 18 years and above at randomization. healthy adults or adults with pre-existing medical conditions who are in stable condition. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease 3 months before enrollment and expected to remain stable for the duration of the study. female participants: a female participant is eligible is the participant is a woman of non-childbearing potential, ie, surgically sterilized or one year post-menopausal. if the participant is a woman of childbearing potential, she must agree to practice sexual abstinence or agree to use medically effective contraception from 14 days before screening to 30 days following the last administration of study intervention. have a negative pregnancy test participant is willing and able to comply with all required study visits and follow-up required by this protocol. participant or the participant's legal representative must understand the procedures of the study and provide written informed consent.

inclusion criteria: male or female participant aged 18 years and above at randomization. healthy adults or adults with pre-existing medical conditions who are in stable condition. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease 3 months before enrollment and expected to remain stable for the duration of the study. female participants: a female participant is eligible is the participant is a woman of non-childbearing potential, ie, surgically sterilized or one year post-menopausal. if the participant is a woman of childbearing potential, she must agree to practice sexual abstinence or agree to use medically effective contraception from 14 days before screening to 30 days following the last administration of study intervention. have a negative pregnancy test participant is willing and able to comply with all required study visits and follow-up required by this protocol. participant or the participant's legal representative must understand the procedures of the study and provide written informed consent.

inclusion criteria: 1. male or female participant aged 18 years and above at randomization. 2. healthy adults or adults with pre-existing medical conditions who are in stable condition. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease 3 months before enrollment and expected to remain stable for the duration of the study. 3. female participants: 1. a female participant is eligible is the participant is a woman of non-childbearing potential, ie, surgically sterilized or one year post-menopausal. 2. if the participant is a woman of childbearing potential, she must agree to practice sexual abstinence or agree to use medically effective contraception from 14 days before screening to 30 days following the last administration of study intervention. 3. have a negative pregnancy test 4. participant is willing and able to comply with all required study visits and follow-up required by this protocol. 5. participant or the participant's legal representative must understand the procedures of the study and provide written informed consent.

inclusion criteria: 1. male or female participant aged 18 years and above at randomization. 2. healthy adults or adults with pre-existing medical conditions who are in stable condition. a stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease 3 months before enrollment and expected to remain stable for the duration of the study. 3. female participants: 1. a female participant is eligible is the participant is a woman of non-childbearing potential, ie, surgically sterilized or one year post-menopausal. 2. if the participant is a woman of childbearing potential, she must agree to practice sexual abstinence or agree to use medically effective contraception from 14 days before screening to 30 days following the last administration of study intervention. 3. have a negative pregnancy test 4. participant is willing and able to comply with all required study visits and follow-up required by this protocol. 5. participant or the participant's legal representative must understand the procedures of the study and provide written informed consent.