inclusion criteria: * confirmed diagnosis of covid-19 by reverse transcription polymerase chain reaction (rt-pcr) * new admission to eligible cuimc icus within 5 days * transfer from nonparticipating to participating icu is eligible if otherwise meets eligibility criteria. * patients transferred between participating icus will maintain initial treatment assignment. * patients not on therapeutic anticoagulation and who were already admitted to participating icu within 5 days of trial initiation are additionally eligible.

inclusion criteria: * confirmed diagnosis of covid-19 by reverse transcription polymerase chain reaction (rt-pcr) * new admission to eligible cuimc icus within 5 days * transfer from nonparticipating to participating icu is eligible if otherwise meets eligibility criteria. * patients transferred between participating icus will maintain initial treatment assignment. * patients not on therapeutic anticoagulation and who were already admitted to participating icu within 5 days of trial initiation are additionally eligible.

inclusion criteria: - confirmed diagnosis of covid-19 by reverse transcription polymerase chain reaction (rt-pcr) - new admission to eligible cuimc icus within 5 days - transfer from nonparticipating to participating icu is eligible if otherwise meets eligibility criteria. - patients transferred between participating icus will maintain initial treatment assignment. - patients not on therapeutic anticoagulation and who were already admitted to participating icu within 5 days of trial initiation are additionally eligible.

inclusion criteria: - confirmed diagnosis of covid-19 by reverse transcription polymerase chain reaction (rt-pcr) - new admission to eligible cuimc icus within 5 days - transfer from nonparticipating to participating icu is eligible if otherwise meets eligibility criteria. - patients transferred between participating icus will maintain initial treatment assignment. - patients not on therapeutic anticoagulation and who were already admitted to participating icu within 5 days of trial initiation are additionally eligible.