inclusion criteria: * female and male adults aged 18 years and older (arm 1-group 1 and arm 2-group 1) and 18-65 years (arm 1 - group 2, arm 2-group 2 and arm3-group1) at the time of consent. * residing within the beira and maputo health region and planning to stay for the study duration. * hiv-negative test result at the day of screening for participants in group 1, in arms 1, 2 and 3 * hiv-positive and on anti-retroviral treatment for at least six months for participants in group 2, in arms 1 and 2 * female volunteers of childbearing potential with a negative pregnancy test on the day(s) of screening and vaccination, practicing/willing to practice continuous effective contraception recommended by the national health system up to four weeks after the third vaccination. * able and willing to comply with all study requirements, based on the assessment of the investigator. * provide written informed consent before any trial procedure.

inclusion criteria: * female and male adults aged 18 years and older (arm 1-group 1 and arm 2-group 1) and 18-65 years (arm 1 - group 2, arm 2-group 2 and arm3-group1) at the time of consent. * residing within the beira and maputo health region and planning to stay for the study duration. * hiv-negative test result at the day of screening for participants in group 1, in arms 1, 2 and 3 * hiv-positive and on anti-retroviral treatment for at least six months for participants in group 2, in arms 1 and 2 * female volunteers of childbearing potential with a negative pregnancy test on the day(s) of screening and vaccination, practicing/willing to practice continuous effective contraception recommended by the national health system up to four weeks after the third vaccination. * able and willing to comply with all study requirements, based on the assessment of the investigator. * provide written informed consent before any trial procedure.

inclusion criteria: - female and male adults aged 18 years and older (arm 1-group 1 and arm 2-group 1) and 18-65 years (arm 1 - group 2, arm 2-group 2 and arm3-group1) at the time of consent. - residing within the beira and maputo health region and planning to stay for the study duration. - hiv-negative test result at the day of screening for participants in group 1, in arms 1, 2 and 3 - hiv-positive and on anti-retroviral treatment for at least six months for participants in group 2, in arms 1 and 2 - female volunteers of childbearing potential with a negative pregnancy test on the day(s) of screening and vaccination, practicing/willing to practice continuous effective contraception recommended by the national health system up to four weeks after the third vaccination. - able and willing to comply with all study requirements, based on the assessment of the investigator. - provide written informed consent before any trial procedure.

inclusion criteria: - female and male adults aged 18 years and older (arm 1-group 1 and arm 2-group 1) and 18-65 years (arm 1 - group 2, arm 2-group 2 and arm3-group1) at the time of consent. - residing within the beira and maputo health region and planning to stay for the study duration. - hiv-negative test result at the day of screening for participants in group 1, in arms 1, 2 and 3 - hiv-positive and on anti-retroviral treatment for at least six months for participants in group 2, in arms 1 and 2 - female volunteers of childbearing potential with a negative pregnancy test on the day(s) of screening and vaccination, practicing/willing to practice continuous effective contraception recommended by the national health system up to four weeks after the third vaccination. - able and willing to comply with all study requirements, based on the assessment of the investigator. - provide written informed consent before any trial procedure.