inclusion criteria: 1. adult patients (18 years or older), both sexes 2. sars-cov-2 infection confirmed by pcr less than 4 days before randomization 3. hospitalized with a diagnosis of sars-cov-2 pneumonia 4. radiographic evidence of pulmonary infiltrates 5. grade 4 or 5 on the ordinal scale for the evaluation of the patient's clinical condition 6. po2/fio2 \<380 7. men and women of childbearing age who have heterosexual relations must be agreement to use the safe method(s) of contraception 8. obtaining the informed consent of the patient or the legal representative.

inclusion criteria: 1. adult patients (18 years or older), both sexes 2. sars-cov-2 infection confirmed by pcr less than 4 days before randomization 3. hospitalized with a diagnosis of sars-cov-2 pneumonia 4. radiographic evidence of pulmonary infiltrates 5. grade 4 or 5 on the ordinal scale for the evaluation of the patient's clinical condition 6. po2/fio2 \<380 7. men and women of childbearing age who have heterosexual relations must be agreement to use the safe method(s) of contraception 8. obtaining the informed consent of the patient or the legal representative.

inclusion criteria: adult patients (18 years or older), both sexes sars-cov-2 infection confirmed by pcr less than 4 days before randomization hospitalized with a diagnosis of sars-cov-2 pneumonia radiographic evidence of pulmonary infiltrates grade 4 or 5 on the ordinal scale for the evaluation of the patient's clinical condition po2/fio2 <380 men and women of childbearing age who have heterosexual relations must be agreement to use the safe method(s) of contraception obtaining the informed consent of the patient or the legal representative.

inclusion criteria: adult patients (18 years or older), both sexes sars-cov-2 infection confirmed by pcr less than 4 days before randomization hospitalized with a diagnosis of sars-cov-2 pneumonia radiographic evidence of pulmonary infiltrates grade 4 or 5 on the ordinal scale for the evaluation of the patient's clinical condition po2/fio2 <380 men and women of childbearing age who have heterosexual relations must be agreement to use the safe method(s) of contraception obtaining the informed consent of the patient or the legal representative.

inclusion criteria: 1. adult patients (18 years or older), both sexes 2. sars-cov-2 infection confirmed by pcr less than 4 days before randomization 3. hospitalized with a diagnosis of sars-cov-2 pneumonia 4. radiographic evidence of pulmonary infiltrates 5. grade 4 or 5 on the ordinal scale for the evaluation of the patient's clinical condition 6. po2/fio2 <380 7. men and women of childbearing age who have heterosexual relations must be agreement to use the safe method(s) of contraception 8. obtaining the informed consent of the patient or the legal representative.

inclusion criteria: 1. adult patients (18 years or older), both sexes 2. sars-cov-2 infection confirmed by pcr less than 4 days before randomization 3. hospitalized with a diagnosis of sars-cov-2 pneumonia 4. radiographic evidence of pulmonary infiltrates 5. grade 4 or 5 on the ordinal scale for the evaluation of the patient's clinical condition 6. po2/fio2 <380 7. men and women of childbearing age who have heterosexual relations must be agreement to use the safe method(s) of contraception 8. obtaining the informed consent of the patient or the legal representative.