1. imminent death (life expectancy less than 72h) 2. known hypersensitivity or known adverse reactions to the study drug, or its metabolites or excipients of the formulation 3. invasive mechanical ventilation 4. participation in any other clinical trial 5. alt or ast \> 5 x uln 6. creatinine clearance \<50 ml/min using the cockcroft-gault formula for participants '18 years old \[cockcroft 1976\] 7. patients with recent acute coronary syndrome (\<1 month) 8. patients with a history of stroke 9. positive pregnancy test 10. pregnant or lactating woman

1. imminent death (life expectancy less than 72h) 2. known hypersensitivity or known adverse reactions to the study drug, or its metabolites or excipients of the formulation 3. invasive mechanical ventilation 4. participation in any other clinical trial 5. alt or ast \> 5 x uln 6. creatinine clearance \<50 ml/min using the cockcroft-gault formula for participants '18 years old \[cockcroft 1976\] 7. patients with recent acute coronary syndrome (\<1 month) 8. patients with a history of stroke 9. positive pregnancy test 10. pregnant or lactating woman

imminent death (life expectancy less than 72h) known hypersensitivity or known adverse reactions to the study drug, or its metabolites or excipients of the formulation invasive mechanical ventilation participation in any other clinical trial alt or ast > 5 x uln creatinine clearance <50 ml/min using the cockcroft-gault formula for participants '18 years old [cockcroft 1976] patients with recent acute coronary syndrome (<1 month) patients with a history of stroke positive pregnancy test pregnant or lactating woman

imminent death (life expectancy less than 72h) known hypersensitivity or known adverse reactions to the study drug, or its metabolites or excipients of the formulation invasive mechanical ventilation participation in any other clinical trial alt or ast > 5 x uln creatinine clearance <50 ml/min using the cockcroft-gault formula for participants '18 years old [cockcroft 1976] patients with recent acute coronary syndrome (<1 month) patients with a history of stroke positive pregnancy test pregnant or lactating woman

1. imminent death (life expectancy less than 72h) 2. known hypersensitivity or known adverse reactions to the study drug, or its metabolites or excipients of the formulation 3. invasive mechanical ventilation 4. participation in any other clinical trial 5. alt or ast > 5 x uln 6. creatinine clearance <50 ml/min using the cockcroft-gault formula for participants '18 years old [cockcroft 1976] 7. patients with recent acute coronary syndrome (<1 month) 8. patients with a history of stroke 9. positive pregnancy test 10. pregnant or lactating woman

1. imminent death (life expectancy less than 72h) 2. known hypersensitivity or known adverse reactions to the study drug, or its metabolites or excipients of the formulation 3. invasive mechanical ventilation 4. participation in any other clinical trial 5. alt or ast > 5 x uln 6. creatinine clearance <50 ml/min using the cockcroft-gault formula for participants '18 years old [cockcroft 1976] 7. patients with recent acute coronary syndrome (<1 month) 8. patients with a history of stroke 9. positive pregnancy test 10. pregnant or lactating woman