* history of chronic infectious disease such as hiv or hepatitis * history of tuberculosis, tb risk factors, positive interferon-gamma release assay (igra, also known as the t-spot.tb test), or bcg vaccination * current treatment with glucocorticoids (other than intermittent nasal or eye steroids), or disease or condition likely to require steroid therapy * other conditions or treatments associated with increased risk of infections such as patients with a previous history of severe burns, or treatment with immunosuppressive medications of any type (e.g. imuran, methotrexate, cyclosporine, etanercept, infliximab) for any reason * current treatment with aspirin \> 160 mg/day or chronic, daily nsaids * current treatment with antibiotics * history of keloid formation * average hba1c over the past 5 years (or since diagnosis if duration is less than 5 years) \<6.5 or \> 8.5% * history or evidence of chronic kidney disease (serum creatinine \> 1.5mg/dl) * history of proliferative diabetic retinopathy that has not been treated with laser therapy * history of neuropathy, foot ulcers, amputations, or kidney disease * pregnant or not using acceptable birth control * living with someone who is immunosuppressed and/or at high risk for infectious diseases (for example hiv+ or taking immunosuppressive medications for any reason)

* history of chronic infectious disease such as hiv or hepatitis * history of tuberculosis, tb risk factors, positive interferon-gamma release assay (igra, also known as the t-spot.tb test), or bcg vaccination * current treatment with glucocorticoids (other than intermittent nasal or eye steroids), or disease or condition likely to require steroid therapy * other conditions or treatments associated with increased risk of infections such as patients with a previous history of severe burns, or treatment with immunosuppressive medications of any type (e.g. imuran, methotrexate, cyclosporine, etanercept, infliximab) for any reason * current treatment with aspirin \> 160 mg/day or chronic, daily nsaids * current treatment with antibiotics * history of keloid formation * average hba1c over the past 5 years (or since diagnosis if duration is less than 5 years) \<6.5 or \> 8.5% * history or evidence of chronic kidney disease (serum creatinine \> 1.5mg/dl) * history of proliferative diabetic retinopathy that has not been treated with laser therapy * history of neuropathy, foot ulcers, amputations, or kidney disease * pregnant or not using acceptable birth control * living with someone who is immunosuppressed and/or at high risk for infectious diseases (for example hiv+ or taking immunosuppressive medications for any reason)

- history of chronic infectious disease such as hiv or hepatitis - history of tuberculosis, tb risk factors, positive interferon-gamma release assay (igra, also known as the t-spot.tb test), or bcg vaccination - current treatment with glucocorticoids (other than intermittent nasal or eye steroids), or disease or condition likely to require steroid therapy - other conditions or treatments associated with increased risk of infections such as patients with a previous history of severe burns, or treatment with immunosuppressive medications of any type (e.g. imuran, methotrexate, cyclosporine, etanercept, infliximab) for any reason - current treatment with aspirin > 160 mg/day or chronic, daily nsaids - current treatment with antibiotics - history of keloid formation - average hba1c over the past 5 years (or since diagnosis if duration is less than 5 years) <6.5 or > 8.5% - history or evidence of chronic kidney disease (serum creatinine > 1.5mg/dl) - history of proliferative diabetic retinopathy that has not been treated with laser therapy - history of neuropathy, foot ulcers, amputations, or kidney disease - pregnant or not using acceptable birth control - living with someone who is immunosuppressed and/or at high risk for infectious diseases (for example hiv+ or taking immunosuppressive medications for any reason)

- history of chronic infectious disease such as hiv or hepatitis - history of tuberculosis, tb risk factors, positive interferon-gamma release assay (igra, also known as the t-spot.tb test), or bcg vaccination - current treatment with glucocorticoids (other than intermittent nasal or eye steroids), or disease or condition likely to require steroid therapy - other conditions or treatments associated with increased risk of infections such as patients with a previous history of severe burns, or treatment with immunosuppressive medications of any type (e.g. imuran, methotrexate, cyclosporine, etanercept, infliximab) for any reason - current treatment with aspirin > 160 mg/day or chronic, daily nsaids - current treatment with antibiotics - history of keloid formation - average hba1c over the past 5 years (or since diagnosis if duration is less than 5 years) <6.5 or > 8.5% - history or evidence of chronic kidney disease (serum creatinine > 1.5mg/dl) - history of proliferative diabetic retinopathy that has not been treated with laser therapy - history of neuropathy, foot ulcers, amputations, or kidney disease - pregnant or not using acceptable birth control - living with someone who is immunosuppressed and/or at high risk for infectious diseases (for example hiv+ or taking immunosuppressive medications for any reason)