inclusion criteria: 1. informed consent prior to performing procedures. the oral consent be accepted testified to prevent paper handling. 2. patient of both sexes, and ≥18 years. 3. sars-cov-2 infection determined by pcr in a sample of naso-oropharyngeal exudate or other respiratory specimen or determination of specific positive igm antibodies, in \<72 hours before randomization. 4. patients requiring hospitalization for pneumonia covid-19 without need until randomization of mechanical ventilation (invasive or non-invasive), and at least one of the following: * o2 saturation ≤ 94% in ambient air, or pao2 / fio2 ≤ 300 mm hg. * age\> 65 years. * presence of: high blood pressure, chronic heart failure, chronic obstructive pulmonary disease, liver cirrhosis, or other chronic pulmonary and cardiovascular diseases, diabetes, or obesity

inclusion criteria: 1. informed consent prior to performing procedures. the oral consent be accepted testified to prevent paper handling. 2. patient of both sexes, and ≥18 years. 3. sars-cov-2 infection determined by pcr in a sample of naso-oropharyngeal exudate or other respiratory specimen or determination of specific positive igm antibodies, in \<72 hours before randomization. 4. patients requiring hospitalization for pneumonia covid-19 without need until randomization of mechanical ventilation (invasive or non-invasive), and at least one of the following: * o2 saturation ≤ 94% in ambient air, or pao2 / fio2 ≤ 300 mm hg. * age\> 65 years. * presence of: high blood pressure, chronic heart failure, chronic obstructive pulmonary disease, liver cirrhosis, or other chronic pulmonary and cardiovascular diseases, diabetes, or obesity

inclusion criteria: informed consent prior to performing procedures. the oral consent be accepted testified to prevent paper handling. patient of both sexes, and ≥18 years. sars-cov-2 infection determined by pcr in a sample of naso-oropharyngeal exudate or other respiratory specimen or determination of specific positive igm antibodies, in <72 hours before randomization. patients requiring hospitalization for pneumonia covid-19 without need until randomization of mechanical ventilation (invasive or non-invasive), and at least one of the following: o2 saturation ≤ 94% in ambient air, or pao2 / fio2 ≤ 300 mm hg. age> 65 years. presence of: high blood pressure, chronic heart failure, chronic obstructive pulmonary disease, liver cirrhosis, or other chronic pulmonary and cardiovascular diseases, diabetes, or obesity

inclusion criteria: informed consent prior to performing procedures. the oral consent be accepted testified to prevent paper handling. patient of both sexes, and ≥18 years. sars-cov-2 infection determined by pcr in a sample of naso-oropharyngeal exudate or other respiratory specimen or determination of specific positive igm antibodies, in <72 hours before randomization. patients requiring hospitalization for pneumonia covid-19 without need until randomization of mechanical ventilation (invasive or non-invasive), and at least one of the following: o2 saturation ≤ 94% in ambient air, or pao2 / fio2 ≤ 300 mm hg. age> 65 years. presence of: high blood pressure, chronic heart failure, chronic obstructive pulmonary disease, liver cirrhosis, or other chronic pulmonary and cardiovascular diseases, diabetes, or obesity

inclusion criteria: 1. informed consent prior to performing procedures. the oral consent be accepted testified to prevent paper handling. 2. patient of both sexes, and ≥18 years. 3. sars-cov-2 infection determined by pcr in a sample of naso-oropharyngeal exudate or other respiratory specimen or determination of specific positive igm antibodies, in <72 hours before randomization. 4. patients requiring hospitalization for pneumonia covid-19 without need until randomization of mechanical ventilation (invasive or non-invasive), and at least one of the following: - o2 saturation ≤ 94% in ambient air, or pao2 / fio2 ≤ 300 mm hg. - age> 65 years. - presence of: high blood pressure, chronic heart failure, chronic obstructive pulmonary disease, liver cirrhosis, or other chronic pulmonary and cardiovascular diseases, diabetes, or obesity

inclusion criteria: 1. informed consent prior to performing procedures. the oral consent be accepted testified to prevent paper handling. 2. patient of both sexes, and ≥18 years. 3. sars-cov-2 infection determined by pcr in a sample of naso-oropharyngeal exudate or other respiratory specimen or determination of specific positive igm antibodies, in <72 hours before randomization. 4. patients requiring hospitalization for pneumonia covid-19 without need until randomization of mechanical ventilation (invasive or non-invasive), and at least one of the following: - o2 saturation ≤ 94% in ambient air, or pao2 / fio2 ≤ 300 mm hg. - age> 65 years. - presence of: high blood pressure, chronic heart failure, chronic obstructive pulmonary disease, liver cirrhosis, or other chronic pulmonary and cardiovascular diseases, diabetes, or obesity