1. requirement before randomization of mechanical ventilation (invasive or non-invasive). 2. any of the following analytical data before randomization: il-6\> 80 pg / ml, d-dimer\> 10 times uln, ferritin\> 1000ng / ml. 3. participation in another clinical trial or experimental treatment for covid-19. 4. in the opinion of the clinical team, progression to death or mechanical ventilation is highly probable within 24 hours, regardless of treatment provision. 5. incompatibility or allergy to the administration of human plasma. 6. severe chronic kidney disease grade 4 or requiring dialysis (ie egfr \<30) 7. pregnant, lactating, or fertile women who are not using an effective method of contraception. it is considered a woman of childbearing age all women from 18 years and up to a year after the last menstrual period in the case of menopausal women

1. requirement before randomization of mechanical ventilation (invasive or non-invasive). 2. any of the following analytical data before randomization: il-6\> 80 pg / ml, d-dimer\> 10 times uln, ferritin\> 1000ng / ml. 3. participation in another clinical trial or experimental treatment for covid-19. 4. in the opinion of the clinical team, progression to death or mechanical ventilation is highly probable within 24 hours, regardless of treatment provision. 5. incompatibility or allergy to the administration of human plasma. 6. severe chronic kidney disease grade 4 or requiring dialysis (ie egfr \<30) 7. pregnant, lactating, or fertile women who are not using an effective method of contraception. it is considered a woman of childbearing age all women from 18 years and up to a year after the last menstrual period in the case of menopausal women

requirement before randomization of mechanical ventilation (invasive or non-invasive). any of the following analytical data before randomization: il-6> 80 pg / ml, d-dimer> 10 times uln, ferritin> 1000ng / ml. participation in another clinical trial or experimental treatment for covid-19. in the opinion of the clinical team, progression to death or mechanical ventilation is highly probable within 24 hours, regardless of treatment provision. incompatibility or allergy to the administration of human plasma. severe chronic kidney disease grade 4 or requiring dialysis (ie egfr <30) pregnant, lactating, or fertile women who are not using an effective method of contraception. it is considered a woman of childbearing age all women from 18 years and up to a year after the last menstrual period in the case of menopausal women

requirement before randomization of mechanical ventilation (invasive or non-invasive). any of the following analytical data before randomization: il-6> 80 pg / ml, d-dimer> 10 times uln, ferritin> 1000ng / ml. participation in another clinical trial or experimental treatment for covid-19. in the opinion of the clinical team, progression to death or mechanical ventilation is highly probable within 24 hours, regardless of treatment provision. incompatibility or allergy to the administration of human plasma. severe chronic kidney disease grade 4 or requiring dialysis (ie egfr <30) pregnant, lactating, or fertile women who are not using an effective method of contraception. it is considered a woman of childbearing age all women from 18 years and up to a year after the last menstrual period in the case of menopausal women

1. requirement before randomization of mechanical ventilation (invasive or non-invasive). 2. any of the following analytical data before randomization: il-6> 80 pg / ml, d-dimer> 10 times uln, ferritin> 1000ng / ml. 3. participation in another clinical trial or experimental treatment for covid-19. 4. in the opinion of the clinical team, progression to death or mechanical ventilation is highly probable within 24 hours, regardless of treatment provision. 5. incompatibility or allergy to the administration of human plasma. 6. severe chronic kidney disease grade 4 or requiring dialysis (ie egfr <30) 7. pregnant, lactating, or fertile women who are not using an effective method of contraception. it is considered a woman of childbearing age all women from 18 years and up to a year after the last menstrual period in the case of menopausal women

1. requirement before randomization of mechanical ventilation (invasive or non-invasive). 2. any of the following analytical data before randomization: il-6> 80 pg / ml, d-dimer> 10 times uln, ferritin> 1000ng / ml. 3. participation in another clinical trial or experimental treatment for covid-19. 4. in the opinion of the clinical team, progression to death or mechanical ventilation is highly probable within 24 hours, regardless of treatment provision. 5. incompatibility or allergy to the administration of human plasma. 6. severe chronic kidney disease grade 4 or requiring dialysis (ie egfr <30) 7. pregnant, lactating, or fertile women who are not using an effective method of contraception. it is considered a woman of childbearing age all women from 18 years and up to a year after the last menstrual period in the case of menopausal women