1. participant has mild, moderate, or critical covid-19 defined in accordance with the fda guidance for industry: a. mild covid-19: i. symptoms of mild illness with covid-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea ii. no clinical signs indicative of moderate, severe, or critical severity b. moderate covid-19: i. symptoms of moderate illness with covid-19, which could include any symptom of mild illness (fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms) or shortness of breath with exertion ii. clinical signs suggestive of moderate illness with covid-19, such as respiratory rate ≥20 breaths per minute, peripheral oxygen saturation (spo₂) \>93% on room air at sea level, heart rate ≥90 beats per minute iii. no clinical signs indicative of severe or critical illness c. critical covid-19: i. respiratory failure defined based on resource utilization requiring at least one of the following: * endotracheal intubation and mechanical ventilation * oxygen delivered by high-flow nasal cannula (\[hfnc\] heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates \>20 l/min with fraction of delivered oxygen ≥0.5) * noninvasive positive pressure ventilation * ecmo, or * clinical diagnosis of respiratory failure (i.e., clinical need for one of the preceding therapies, but preceding therapies not able to be administered in setting of resource limitation) ii. shock (defined by systolic blood pressure \<90 mmhg, or diastolic blood pressure \<60 mmhg or requiring vasopressors) iii. multi-organ dysfunction/failure. 2. participant has taken investigational medications within 7 days or 5 half-lives prior to enrollment, whichever is shorter. 3. participant has required any new form of sedation, anxiolysis or central nervous system (cns) depressant within the 48 hours prior to enrollment that would interfere with neurologic assessments at enrollment. 4. has history of cerebrovascular accident or intracranial bleeding of any kind, acute coronary syndrome, myocardial infarction, or severe pulmonary hypertension. 5. participant has chronic respiratory failure not associated with covid-19, defined as prior need for home oxygen, need for home noninvasive positive-pressure ventilation (nippv) for reasons other than isolated sleep apnea, or other signs of chronic respiratory failure, in the investigator's judgment. 6. upper gastrointestinal (gi) bleed evidenced by hematemesis, "coffee-ground" emesis or nasogastric aspirate, or hematochezia thought to originate from upper gi tract. 7. participant has abnormal liver function defined as any 2 of the following at screening: 1. total bilirubin ≥2 × uln 2. alanine aminotransferase (alt) ≥3 × uln 3. aspartate aminotransferase (ast) ≥3 × uln 4. alkaline phosphatase (alp) \>3 × uln 5. gamma-glutamyl transferase (ggt) \>3 × uln 8. participant has an estimated glomerular filtration rate (egfr) \<60 ml/min. 9. participant has a known allergy or significant adverse reaction to varespladib-methyl or related compounds. 10. participant is considered by the investigator to be unable to comply with protocol requirements due to geographic considerations, psychiatric disorders, or other compliance concerns; or has any serious medical condition or clinically significant laboratory, ecg, vital sign, or physical examination abnormality that would prevent study participation or place the participant at significant risk, as judged by the investigator. 11. participant is breast-feeding, pregnant, has a positive serum hcg pregnancy test, or is not willing to use a highly effective method of contraception for 14 days after treatment. highly effective methods of contraception are as follows: 1. combined (estrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal) 2. progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, or implantable) 3. intrauterine device, intrauterine hormone-releasing system 4. bilateral tubal occlusion 5. vasectomized partner 6. sexual abstinence 7. double-barrier method (condoms, sponge, diaphragm, with spermicidal jellies, or cream).

1. participant has mild, moderate, or critical covid-19 defined in accordance with the fda guidance for industry: a. mild covid-19: i. symptoms of mild illness with covid-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea ii. no clinical signs indicative of moderate, severe, or critical severity b. moderate covid-19: i. symptoms of moderate illness with covid-19, which could include any symptom of mild illness (fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms) or shortness of breath with exertion ii. clinical signs suggestive of moderate illness with covid-19, such as respiratory rate ≥20 breaths per minute, peripheral oxygen saturation (spo₂) \>93% on room air at sea level, heart rate ≥90 beats per minute iii. no clinical signs indicative of severe or critical illness c. critical covid-19: i. respiratory failure defined based on resource utilization requiring at least one of the following: * endotracheal intubation and mechanical ventilation * oxygen delivered by high-flow nasal cannula (\[hfnc\] heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates \>20 l/min with fraction of delivered oxygen ≥0.5) * noninvasive positive pressure ventilation * ecmo, or * clinical diagnosis of respiratory failure (i.e., clinical need for one of the preceding therapies, but preceding therapies not able to be administered in setting of resource limitation) ii. shock (defined by systolic blood pressure \<90 mmhg, or diastolic blood pressure \<60 mmhg or requiring vasopressors) iii. multi-organ dysfunction/failure. 2. participant has taken investigational medications within 7 days or 5 half-lives prior to enrollment, whichever is shorter. 3. participant has required any new form of sedation, anxiolysis or central nervous system (cns) depressant within the 48 hours prior to enrollment that would interfere with neurologic assessments at enrollment. 4. has history of cerebrovascular accident or intracranial bleeding of any kind, acute coronary syndrome, myocardial infarction, or severe pulmonary hypertension. 5. participant has chronic respiratory failure not associated with covid-19, defined as prior need for home oxygen, need for home noninvasive positive-pressure ventilation (nippv) for reasons other than isolated sleep apnea, or other signs of chronic respiratory failure, in the investigator's judgment. 6. upper gastrointestinal (gi) bleed evidenced by hematemesis, "coffee-ground" emesis or nasogastric aspirate, or hematochezia thought to originate from upper gi tract. 7. participant has abnormal liver function defined as any 2 of the following at screening: 1. total bilirubin ≥2 × uln 2. alanine aminotransferase (alt) ≥3 × uln 3. aspartate aminotransferase (ast) ≥3 × uln 4. alkaline phosphatase (alp) \>3 × uln 5. gamma-glutamyl transferase (ggt) \>3 × uln 8. participant has an estimated glomerular filtration rate (egfr) \<60 ml/min. 9. participant has a known allergy or significant adverse reaction to varespladib-methyl or related compounds. 10. participant is considered by the investigator to be unable to comply with protocol requirements due to geographic considerations, psychiatric disorders, or other compliance concerns; or has any serious medical condition or clinically significant laboratory, ecg, vital sign, or physical examination abnormality that would prevent study participation or place the participant at significant risk, as judged by the investigator. 11. participant is breast-feeding, pregnant, has a positive serum hcg pregnancy test, or is not willing to use a highly effective method of contraception for 14 days after treatment. highly effective methods of contraception are as follows: 1. combined (estrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal) 2. progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, or implantable) 3. intrauterine device, intrauterine hormone-releasing system 4. bilateral tubal occlusion 5. vasectomized partner 6. sexual abstinence 7. double-barrier method (condoms, sponge, diaphragm, with spermicidal jellies, or cream).

participant has mild, moderate, or critical covid-19 defined in accordance with the fda guidance for industry: a. mild covid-19: i. symptoms of mild illness with covid-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea ii. no clinical signs indicative of moderate, severe, or critical severity b. moderate covid-19: i. symptoms of moderate illness with covid-19, which could include any symptom of mild illness (fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms) or shortness of breath with exertion ii. clinical signs suggestive of moderate illness with covid-19, such as respiratory rate ≥20 breaths per minute, peripheral oxygen saturation (spo₂) >93% on room air at sea level, heart rate ≥90 beats per minute iii. no clinical signs indicative of severe or critical illness c. critical covid-19: i. respiratory failure defined based on resource utilization requiring at least one of the following: endotracheal intubation and mechanical ventilation oxygen delivered by high-flow nasal cannula ([hfnc] heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates >20 l/min with fraction of delivered oxygen ≥0.5) noninvasive positive pressure ventilation ecmo, or clinical diagnosis of respiratory failure (i.e., clinical need for one of the preceding therapies, but preceding therapies not able to be administered in setting of resource limitation) ii. shock (defined by systolic blood pressure <90 mmhg, or diastolic blood pressure <60 mmhg or requiring vasopressors) iii. multi-organ dysfunction/failure. participant has taken investigational medications within 7 days or 5 half-lives prior to enrollment, whichever is shorter. participant has required any new form of sedation, anxiolysis or central nervous system (cns) depressant within the 48 hours prior to enrollment that would interfere with neurologic assessments at enrollment. has history of cerebrovascular accident or intracranial bleeding of any kind, acute coronary syndrome, myocardial infarction, or severe pulmonary hypertension. participant has chronic respiratory failure not associated with covid-19, defined as prior need for home oxygen, need for home noninvasive positive-pressure ventilation (nippv) for reasons other than isolated sleep apnea, or other signs of chronic respiratory failure, in the investigator's judgment. upper gastrointestinal (gi) bleed evidenced by hematemesis, "coffee-ground" emesis or nasogastric aspirate, or hematochezia thought to originate from upper gi tract. participant has abnormal liver function defined as any 2 of the following at screening: total bilirubin ≥2 × uln alanine aminotransferase (alt) ≥3 × uln aspartate aminotransferase (ast) ≥3 × uln alkaline phosphatase (alp) >3 × uln gamma-glutamyl transferase (ggt) >3 × uln participant has an estimated glomerular filtration rate (egfr) <60 ml/min. participant has a known allergy or significant adverse reaction to varespladib-methyl or related compounds. participant is considered by the investigator to be unable to comply with protocol requirements due to geographic considerations, psychiatric disorders, or other compliance concerns; or has any serious medical condition or clinically significant laboratory, ecg, vital sign, or physical examination abnormality that would prevent study participation or place the participant at significant risk, as judged by the investigator. participant is breast-feeding, pregnant, has a positive serum hcg pregnancy test, or is not willing to use a highly effective method of contraception for 14 days after treatment. highly effective methods of contraception are as follows: combined (estrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal) progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, or implantable) intrauterine device, intrauterine hormone-releasing system bilateral tubal occlusion vasectomized partner sexual abstinence double-barrier method (condoms, sponge, diaphragm, with spermicidal jellies, or cream).

participant has mild, moderate, or critical covid-19 defined in accordance with the fda guidance for industry: a. mild covid-19: i. symptoms of mild illness with covid-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea ii. no clinical signs indicative of moderate, severe, or critical severity b. moderate covid-19: i. symptoms of moderate illness with covid-19, which could include any symptom of mild illness (fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms) or shortness of breath with exertion ii. clinical signs suggestive of moderate illness with covid-19, such as respiratory rate ≥20 breaths per minute, peripheral oxygen saturation (spo₂) >93% on room air at sea level, heart rate ≥90 beats per minute iii. no clinical signs indicative of severe or critical illness c. critical covid-19: i. respiratory failure defined based on resource utilization requiring at least one of the following: endotracheal intubation and mechanical ventilation oxygen delivered by high-flow nasal cannula ([hfnc] heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates >20 l/min with fraction of delivered oxygen ≥0.5) noninvasive positive pressure ventilation ecmo, or clinical diagnosis of respiratory failure (i.e., clinical need for one of the preceding therapies, but preceding therapies not able to be administered in setting of resource limitation) ii. shock (defined by systolic blood pressure <90 mmhg, or diastolic blood pressure <60 mmhg or requiring vasopressors) iii. multi-organ dysfunction/failure. participant has taken investigational medications within 7 days or 5 half-lives prior to enrollment, whichever is shorter. participant has required any new form of sedation, anxiolysis or central nervous system (cns) depressant within the 48 hours prior to enrollment that would interfere with neurologic assessments at enrollment. has history of cerebrovascular accident or intracranial bleeding of any kind, acute coronary syndrome, myocardial infarction, or severe pulmonary hypertension. participant has chronic respiratory failure not associated with covid-19, defined as prior need for home oxygen, need for home noninvasive positive-pressure ventilation (nippv) for reasons other than isolated sleep apnea, or other signs of chronic respiratory failure, in the investigator's judgment. upper gastrointestinal (gi) bleed evidenced by hematemesis, "coffee-ground" emesis or nasogastric aspirate, or hematochezia thought to originate from upper gi tract. participant has abnormal liver function defined as any 2 of the following at screening: total bilirubin ≥2 × uln alanine aminotransferase (alt) ≥3 × uln aspartate aminotransferase (ast) ≥3 × uln alkaline phosphatase (alp) >3 × uln gamma-glutamyl transferase (ggt) >3 × uln participant has an estimated glomerular filtration rate (egfr) <60 ml/min. participant has a known allergy or significant adverse reaction to varespladib-methyl or related compounds. participant is considered by the investigator to be unable to comply with protocol requirements due to geographic considerations, psychiatric disorders, or other compliance concerns; or has any serious medical condition or clinically significant laboratory, ecg, vital sign, or physical examination abnormality that would prevent study participation or place the participant at significant risk, as judged by the investigator. participant is breast-feeding, pregnant, has a positive serum hcg pregnancy test, or is not willing to use a highly effective method of contraception for 14 days after treatment. highly effective methods of contraception are as follows: combined (estrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal) progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, or implantable) intrauterine device, intrauterine hormone-releasing system bilateral tubal occlusion vasectomized partner sexual abstinence double-barrier method (condoms, sponge, diaphragm, with spermicidal jellies, or cream).

1. participant has mild, moderate, or critical covid-19 defined in accordance with the fda guidance for industry: a. mild covid-19: i. symptoms of mild illness with covid-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea ii. no clinical signs indicative of moderate, severe, or critical severity b. moderate covid-19: i. symptoms of moderate illness with covid-19, which could include any symptom of mild illness (fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms) or shortness of breath with exertion ii. clinical signs suggestive of moderate illness with covid-19, such as respiratory rate ≥20 breaths per minute, peripheral oxygen saturation (spo₂) >93% on room air at sea level, heart rate ≥90 beats per minute iii. no clinical signs indicative of severe or critical illness c. critical covid-19: i. respiratory failure defined based on resource utilization requiring at least one of the following: - endotracheal intubation and mechanical ventilation - oxygen delivered by high-flow nasal cannula ([hfnc] heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates >20 l/min with fraction of delivered oxygen ≥0.5) - noninvasive positive pressure ventilation - ecmo, or - clinical diagnosis of respiratory failure (i.e., clinical need for one of the preceding therapies, but preceding therapies not able to be administered in setting of resource limitation) ii. shock (defined by systolic blood pressure <90 mmhg, or diastolic blood pressure <60 mmhg or requiring vasopressors) iii. multi-organ dysfunction/failure. 2. participant has taken investigational medications within 7 days or 5 half-lives prior to enrollment, whichever is shorter. 3. participant has required any new form of sedation, anxiolysis or central nervous system (cns) depressant within the 48 hours prior to enrollment that would interfere with neurologic assessments at enrollment. 4. has history of cerebrovascular accident or intracranial bleeding of any kind, acute coronary syndrome, myocardial infarction, or severe pulmonary hypertension. 5. participant has chronic respiratory failure not associated with covid-19, defined as prior need for home oxygen, need for home noninvasive positive-pressure ventilation (nippv) for reasons other than isolated sleep apnea, or other signs of chronic respiratory failure, in the investigator's judgment. 6. upper gastrointestinal (gi) bleed evidenced by hematemesis, "coffee-ground" emesis or nasogastric aspirate, or hematochezia thought to originate from upper gi tract. 7. participant has abnormal liver function defined as any 2 of the following at screening: 1. total bilirubin ≥2 × uln 2. alanine aminotransferase (alt) ≥3 × uln 3. aspartate aminotransferase (ast) ≥3 × uln 4. alkaline phosphatase (alp) >3 × uln 5. gamma-glutamyl transferase (ggt) >3 × uln 8. participant has an estimated glomerular filtration rate (egfr) <60 ml/min. 9. participant has a known allergy or significant adverse reaction to varespladib-methyl or related compounds. 10. participant is considered by the investigator to be unable to comply with protocol requirements due to geographic considerations, psychiatric disorders, or other compliance concerns; or has any serious medical condition or clinically significant laboratory, ecg, vital sign, or physical examination abnormality that would prevent study participation or place the participant at significant risk, as judged by the investigator. 11. participant is breast-feeding, pregnant, has a positive serum hcg pregnancy test, or is not willing to use a highly effective method of contraception for 14 days after treatment. highly effective methods of contraception are as follows: 1. combined (estrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal) 2. progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, or implantable) 3. intrauterine device, intrauterine hormone-releasing system 4. bilateral tubal occlusion 5. vasectomized partner 6. sexual abstinence 7. double-barrier method (condoms, sponge, diaphragm, with spermicidal jellies, or cream).

1. participant has mild, moderate, or critical covid-19 defined in accordance with the fda guidance for industry: a. mild covid-19: i. symptoms of mild illness with covid-19 that could include fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms, without shortness of breath or dyspnea ii. no clinical signs indicative of moderate, severe, or critical severity b. moderate covid-19: i. symptoms of moderate illness with covid-19, which could include any symptom of mild illness (fever, cough, sore throat, malaise, headache, muscle pain, gastrointestinal symptoms) or shortness of breath with exertion ii. clinical signs suggestive of moderate illness with covid-19, such as respiratory rate ≥20 breaths per minute, peripheral oxygen saturation (spo₂) >93% on room air at sea level, heart rate ≥90 beats per minute iii. no clinical signs indicative of severe or critical illness c. critical covid-19: i. respiratory failure defined based on resource utilization requiring at least one of the following: - endotracheal intubation and mechanical ventilation - oxygen delivered by high-flow nasal cannula ([hfnc] heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates >20 l/min with fraction of delivered oxygen ≥0.5) - noninvasive positive pressure ventilation - ecmo, or - clinical diagnosis of respiratory failure (i.e., clinical need for one of the preceding therapies, but preceding therapies not able to be administered in setting of resource limitation) ii. shock (defined by systolic blood pressure <90 mmhg, or diastolic blood pressure <60 mmhg or requiring vasopressors) iii. multi-organ dysfunction/failure. 2. participant has taken investigational medications within 7 days or 5 half-lives prior to enrollment, whichever is shorter. 3. participant has required any new form of sedation, anxiolysis or central nervous system (cns) depressant within the 48 hours prior to enrollment that would interfere with neurologic assessments at enrollment. 4. has history of cerebrovascular accident or intracranial bleeding of any kind, acute coronary syndrome, myocardial infarction, or severe pulmonary hypertension. 5. participant has chronic respiratory failure not associated with covid-19, defined as prior need for home oxygen, need for home noninvasive positive-pressure ventilation (nippv) for reasons other than isolated sleep apnea, or other signs of chronic respiratory failure, in the investigator's judgment. 6. upper gastrointestinal (gi) bleed evidenced by hematemesis, "coffee-ground" emesis or nasogastric aspirate, or hematochezia thought to originate from upper gi tract. 7. participant has abnormal liver function defined as any 2 of the following at screening: 1. total bilirubin ≥2 × uln 2. alanine aminotransferase (alt) ≥3 × uln 3. aspartate aminotransferase (ast) ≥3 × uln 4. alkaline phosphatase (alp) >3 × uln 5. gamma-glutamyl transferase (ggt) >3 × uln 8. participant has an estimated glomerular filtration rate (egfr) <60 ml/min. 9. participant has a known allergy or significant adverse reaction to varespladib-methyl or related compounds. 10. participant is considered by the investigator to be unable to comply with protocol requirements due to geographic considerations, psychiatric disorders, or other compliance concerns; or has any serious medical condition or clinically significant laboratory, ecg, vital sign, or physical examination abnormality that would prevent study participation or place the participant at significant risk, as judged by the investigator. 11. participant is breast-feeding, pregnant, has a positive serum hcg pregnancy test, or is not willing to use a highly effective method of contraception for 14 days after treatment. highly effective methods of contraception are as follows: 1. combined (estrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation (oral, intravaginal, or transdermal) 2. progestogen-only hormonal contraception associated with inhibition of ovulation (oral, injectable, or implantable) 3. intrauterine device, intrauterine hormone-releasing system 4. bilateral tubal occlusion 5. vasectomized partner 6. sexual abstinence 7. double-barrier method (condoms, sponge, diaphragm, with spermicidal jellies, or cream).