inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test 2. age 18-80 years 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate \> 23/min and \< 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates \>50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score\> 450 u/l ii. crp \>50 mg/l iii. ferritin \>1650 ng/ml iv. lymphocytes \>800 cells/mm3 v. d-dimers \>1 mcg/ml 4. willing and able to sign an informed consent

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test 2. age 18-80 years 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate \> 23/min and \< 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates \>50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score\> 450 u/l ii. crp \>50 mg/l iii. ferritin \>1650 ng/ml iv. lymphocytes \>800 cells/mm3 v. d-dimers \>1 mcg/ml 4. willing and able to sign an informed consent

inclusion criteria: a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test age 18-80 years severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score> 450 u/l ii. crp >50 mg/l iii. ferritin >1650 ng/ml iv. lymphocytes >800 cells/mm3 v. d-dimers >1 mcg/ml willing and able to sign an informed consent

inclusion criteria: a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test age 18-80 years severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score> 450 u/l ii. crp >50 mg/l iii. ferritin >1650 ng/ml iv. lymphocytes >800 cells/mm3 v. d-dimers >1 mcg/ml willing and able to sign an informed consent

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test 2. age 18-80 years 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score> 450 u/l ii. crp >50 mg/l iii. ferritin >1650 ng/ml iv. lymphocytes >800 cells/mm3 v. d-dimers >1 mcg/ml 4. willing and able to sign an informed consent

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test 2. age 18-80 years 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score> 450 u/l ii. crp >50 mg/l iii. ferritin >1650 ng/ml iv. lymphocytes >800 cells/mm3 v. d-dimers >1 mcg/ml 4. willing and able to sign an informed consent

inclusion criteria: a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test age 18-80 years severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score> 450 u/l ii. crp >50 mg/l iii. ferritin >1650 ng/ml iv. lymphocytes >800 cells/mm3 v. d-dimers >1 mcg/ml willing and able to sign an informed consent

inclusion criteria: a covid-19 diagnosis confirmed with a sars-cov-2 viral infection positive polymerase chain reaction (pcr) test age 18-80 years severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission b. evidence of an exacerbated inflammatory process i. ldh score> 450 u/l ii. crp >50 mg/l iii. ferritin >1650 ng/ml iv. lymphocytes >800 cells/mm3 v. d-dimers >1 mcg/ml willing and able to sign an informed consent