1. age\<18 years or \>80 years 2. any concomitant illness that, based on the judgment of the investigator is terminal 3. ventilated patient 4. pregnancy (positive urine pregnancy test \[women of childbearing potential only\]) or breastfeeding 5. patients with immunodeficiency (eg, cll, hiv, rituximab therapy) 6. unwilling or unable to provide informed consent 7. participation in any other interventional study in the last 30 days

1. age\<18 years or \>80 years 2. any concomitant illness that, based on the judgment of the investigator is terminal 3. ventilated patient 4. pregnancy (positive urine pregnancy test \[women of childbearing potential only\]) or breastfeeding 5. patients with immunodeficiency (eg, cll, hiv, rituximab therapy) 6. unwilling or unable to provide informed consent 7. participation in any other interventional study in the last 30 days

age<18 years or >80 years any concomitant illness that, based on the judgment of the investigator is terminal ventilated patient pregnancy (positive urine pregnancy test [women of childbearing potential only]) or breastfeeding patients with immunodeficiency (eg, cll, hiv, rituximab therapy) unwilling or unable to provide informed consent participation in any other interventional study in the last 30 days

age<18 years or >80 years any concomitant illness that, based on the judgment of the investigator is terminal ventilated patient pregnancy (positive urine pregnancy test [women of childbearing potential only]) or breastfeeding patients with immunodeficiency (eg, cll, hiv, rituximab therapy) unwilling or unable to provide informed consent participation in any other interventional study in the last 30 days

1. age<18 years or >80 years 2. any concomitant illness that, based on the judgment of the investigator is terminal 3. ventilated patient 4. pregnancy (positive urine pregnancy test [women of childbearing potential only]) or breastfeeding 5. patients with immunodeficiency (eg, cll, hiv, rituximab therapy) 6. unwilling or unable to provide informed consent 7. participation in any other interventional study in the last 30 days

1. age<18 years or >80 years 2. any concomitant illness that, based on the judgment of the investigator is terminal 3. ventilated patient 4. pregnancy (positive urine pregnancy test [women of childbearing potential only]) or breastfeeding 5. patients with immunodeficiency (eg, cll, hiv, rituximab therapy) 6. unwilling or unable to provide informed consent 7. participation in any other interventional study in the last 30 days

age<18 years or >80 years any concomitant illness that, based on the judgment of the investigator is terminal ventilated patient pregnancy (positive urine pregnancy test [women of childbearing potential only]) or breastfeeding patients with immunodeficiency (eg, cll, hiv, rituximab therapy) unwilling or unable to provide informed consent participation in any other interventional study in the last 30 days

age<18 years or >80 years any concomitant illness that, based on the judgment of the investigator is terminal ventilated patient pregnancy (positive urine pregnancy test [women of childbearing potential only]) or breastfeeding patients with immunodeficiency (eg, cll, hiv, rituximab therapy) unwilling or unable to provide informed consent participation in any other interventional study in the last 30 days