inclusion criteria: * age equal or over 18 and under 90 years old. * confirmed covid-19 positive diagnostic through pcr. * radiological image compatible with non-cardiogenic bilateral pleuropulmonary exudate. * patient has received anti-viral and anti-inflammatory therapy. * present any of the following clinical-functional criteria: 1. respiratory distress: tachypnea\> 30 breaths / minute 2. partial arterial oxygen pressure (pao2) / fraction of inspiration (fio2) ≤ 300 mmhg * signed informed consent, directly or delegated.

inclusion criteria: * age equal or over 18 and under 90 years old. * confirmed covid-19 positive diagnostic through pcr. * radiological image compatible with non-cardiogenic bilateral pleuropulmonary exudate. * patient has received anti-viral and anti-inflammatory therapy. * present any of the following clinical-functional criteria: 1. respiratory distress: tachypnea\> 30 breaths / minute 2. partial arterial oxygen pressure (pao2) / fraction of inspiration (fio2) ≤ 300 mmhg * signed informed consent, directly or delegated.

inclusion criteria: age equal or over 18 and under 90 years old. confirmed covid-19 positive diagnostic through pcr. radiological image compatible with non-cardiogenic bilateral pleuropulmonary exudate. patient has received anti-viral and anti-inflammatory therapy. present any of the following clinical-functional criteria: respiratory distress: tachypnea> 30 breaths / minute partial arterial oxygen pressure (pao2) / fraction of inspiration (fio2) ≤ 300 mmhg signed informed consent, directly or delegated.

inclusion criteria: age equal or over 18 and under 90 years old. confirmed covid-19 positive diagnostic through pcr. radiological image compatible with non-cardiogenic bilateral pleuropulmonary exudate. patient has received anti-viral and anti-inflammatory therapy. present any of the following clinical-functional criteria: respiratory distress: tachypnea> 30 breaths / minute partial arterial oxygen pressure (pao2) / fraction of inspiration (fio2) ≤ 300 mmhg signed informed consent, directly or delegated.

inclusion criteria: - age equal or over 18 and under 90 years old. - confirmed covid-19 positive diagnostic through pcr. - radiological image compatible with non-cardiogenic bilateral pleuropulmonary exudate. - patient has received anti-viral and anti-inflammatory therapy. - present any of the following clinical-functional criteria: 1. respiratory distress: tachypnea> 30 breaths / minute 2. partial arterial oxygen pressure (pao2) / fraction of inspiration (fio2) ≤ 300 mmhg - signed informed consent, directly or delegated.

inclusion criteria: - age equal or over 18 and under 90 years old. - confirmed covid-19 positive diagnostic through pcr. - radiological image compatible with non-cardiogenic bilateral pleuropulmonary exudate. - patient has received anti-viral and anti-inflammatory therapy. - present any of the following clinical-functional criteria: 1. respiratory distress: tachypnea> 30 breaths / minute 2. partial arterial oxygen pressure (pao2) / fraction of inspiration (fio2) ≤ 300 mmhg - signed informed consent, directly or delegated.