* history of sars-cov-2 infection; * have received any covid-19 vaccine; * participants with abnormal fasting blood glucose or diabetes; * history of asthma, history of allergy to the vaccine or vaccine components,or serious adverse reactions to the vaccine, such as urticaria, dyspnea,and angioedema; * autoimmune disease or immunodeficiency / immunosuppression; * severe chronic diseases, severe cardiovascular diseases, hypertension and diabetes that cannot be controlled by drugs, liver or kidney diseases, malignant tumors, etc.; * severe neurological disease (epilepsy, convulsions or convulsions) or mental illness; * thyroid disease or history of thyroidectomy, spleenlessness, functional spleenlessness, spleenlessness or splenectomy resulting from any condition; * diagnosed abnormal blood coagulation function (eg, lack of blood coagulation factors, blood coagulopathy, abnormal platelets) or obvious bruising or blood coagulation; * diseases or factors that are prone to thrombosis or bleeding, such as thrombophlebitis, major surgery/trauma, hereditary thrombotic disorder, sepsis, inflammatory bowel disease, severe varicose veins, may-thurner syndrome, fibrinolytic activity enhancement disease, history of cardiac stent surgery, allergic purpura, etc.; * immunosuppressive therapy, cytotoxic therapy, inhaled corticosteroids (excluding allergic rhinitis corticosteroid spray therapy, acute noncomplicated dermatitis superficial corticosteroid therapy) in the past 6 months; * abnormal hematological laboratory test results outside the reference range during previous physical examination within one year: blood routine indicators (white blood cell count, hemoglobin, platelet count), coagulation function test (prothrombin time pt, activated partial prothrombin time aptt, fibrinogen fib, thrombin time tt, international standardized ratio inr, d-dimer), other indicators (blood glucose, platelet factor 4 hit elisa, erythrocyte sedimentation rate); * history of alcohol or drug abuse; * receipt of blood products within in the past 3 months; * receipt of other investigational drugs in the past 30 days; * receipt of attenuated live vaccines in the past 14 days; * receipt of inactivated or subunit vaccines in the past 7 days; * axillary temperature \>37.0°c; * already pregnant (including a positive urine pregnancy test) or are breastfeeding, planning to get pregnant within 3 months; * history of taking aspirin drugs and other drugs that affect blood coagulation; * according to the investigator's judgment, the subject has any other factors that are not suitable for participating in the clinical trial.

* history of sars-cov-2 infection; * have received any covid-19 vaccine; * participants with abnormal fasting blood glucose or diabetes; * history of asthma, history of allergy to the vaccine or vaccine components,or serious adverse reactions to the vaccine, such as urticaria, dyspnea,and angioedema; * autoimmune disease or immunodeficiency / immunosuppression; * severe chronic diseases, severe cardiovascular diseases, hypertension and diabetes that cannot be controlled by drugs, liver or kidney diseases, malignant tumors, etc.; * severe neurological disease (epilepsy, convulsions or convulsions) or mental illness; * thyroid disease or history of thyroidectomy, spleenlessness, functional spleenlessness, spleenlessness or splenectomy resulting from any condition; * diagnosed abnormal blood coagulation function (eg, lack of blood coagulation factors, blood coagulopathy, abnormal platelets) or obvious bruising or blood coagulation; * diseases or factors that are prone to thrombosis or bleeding, such as thrombophlebitis, major surgery/trauma, hereditary thrombotic disorder, sepsis, inflammatory bowel disease, severe varicose veins, may-thurner syndrome, fibrinolytic activity enhancement disease, history of cardiac stent surgery, allergic purpura, etc.; * immunosuppressive therapy, cytotoxic therapy, inhaled corticosteroids (excluding allergic rhinitis corticosteroid spray therapy, acute noncomplicated dermatitis superficial corticosteroid therapy) in the past 6 months; * abnormal hematological laboratory test results outside the reference range during previous physical examination within one year: blood routine indicators (white blood cell count, hemoglobin, platelet count), coagulation function test (prothrombin time pt, activated partial prothrombin time aptt, fibrinogen fib, thrombin time tt, international standardized ratio inr, d-dimer), other indicators (blood glucose, platelet factor 4 hit elisa, erythrocyte sedimentation rate); * history of alcohol or drug abuse; * receipt of blood products within in the past 3 months; * receipt of other investigational drugs in the past 30 days; * receipt of attenuated live vaccines in the past 14 days; * receipt of inactivated or subunit vaccines in the past 7 days; * axillary temperature \>37.0°c; * already pregnant (including a positive urine pregnancy test) or are breastfeeding, planning to get pregnant within 3 months; * history of taking aspirin drugs and other drugs that affect blood coagulation; * according to the investigator's judgment, the subject has any other factors that are not suitable for participating in the clinical trial.

- history of sars-cov-2 infection; - have received any covid-19 vaccine; - participants with abnormal fasting blood glucose or diabetes; - history of asthma, history of allergy to the vaccine or vaccine components,or serious adverse reactions to the vaccine, such as urticaria, dyspnea,and angioedema; - autoimmune disease or immunodeficiency / immunosuppression; - severe chronic diseases, severe cardiovascular diseases, hypertension and diabetes that cannot be controlled by drugs, liver or kidney diseases, malignant tumors, etc.; - severe neurological disease (epilepsy, convulsions or convulsions) or mental illness; - thyroid disease or history of thyroidectomy, spleenlessness, functional spleenlessness, spleenlessness or splenectomy resulting from any condition; - diagnosed abnormal blood coagulation function (eg, lack of blood coagulation factors, blood coagulopathy, abnormal platelets) or obvious bruising or blood coagulation; - diseases or factors that are prone to thrombosis or bleeding, such as thrombophlebitis, major surgery/trauma, hereditary thrombotic disorder, sepsis, inflammatory bowel disease, severe varicose veins, may-thurner syndrome, fibrinolytic activity enhancement disease, history of cardiac stent surgery, allergic purpura, etc.; - immunosuppressive therapy, cytotoxic therapy, inhaled corticosteroids (excluding allergic rhinitis corticosteroid spray therapy, acute noncomplicated dermatitis superficial corticosteroid therapy) in the past 6 months; - abnormal hematological laboratory test results outside the reference range during previous physical examination within one year: blood routine indicators (white blood cell count, hemoglobin, platelet count), coagulation function test (prothrombin time pt, activated partial prothrombin time aptt, fibrinogen fib, thrombin time tt, international standardized ratio inr, d-dimer), other indicators (blood glucose, platelet factor 4 hit elisa, erythrocyte sedimentation rate); - history of alcohol or drug abuse; - receipt of blood products within in the past 3 months; - receipt of other investigational drugs in the past 30 days; - receipt of attenuated live vaccines in the past 14 days; - receipt of inactivated or subunit vaccines in the past 7 days; - axillary temperature >37.0°c; - already pregnant (including a positive urine pregnancy test) or are breastfeeding, planning to get pregnant within 3 months; - history of taking aspirin drugs and other drugs that affect blood coagulation; - according to the investigator's judgment, the subject has any other factors that are not suitable for participating in the clinical trial.

- history of sars-cov-2 infection; - have received any covid-19 vaccine; - participants with abnormal fasting blood glucose or diabetes; - history of asthma, history of allergy to the vaccine or vaccine components,or serious adverse reactions to the vaccine, such as urticaria, dyspnea,and angioedema; - autoimmune disease or immunodeficiency / immunosuppression; - severe chronic diseases, severe cardiovascular diseases, hypertension and diabetes that cannot be controlled by drugs, liver or kidney diseases, malignant tumors, etc.; - severe neurological disease (epilepsy, convulsions or convulsions) or mental illness; - thyroid disease or history of thyroidectomy, spleenlessness, functional spleenlessness, spleenlessness or splenectomy resulting from any condition; - diagnosed abnormal blood coagulation function (eg, lack of blood coagulation factors, blood coagulopathy, abnormal platelets) or obvious bruising or blood coagulation; - diseases or factors that are prone to thrombosis or bleeding, such as thrombophlebitis, major surgery/trauma, hereditary thrombotic disorder, sepsis, inflammatory bowel disease, severe varicose veins, may-thurner syndrome, fibrinolytic activity enhancement disease, history of cardiac stent surgery, allergic purpura, etc.; - immunosuppressive therapy, cytotoxic therapy, inhaled corticosteroids (excluding allergic rhinitis corticosteroid spray therapy, acute noncomplicated dermatitis superficial corticosteroid therapy) in the past 6 months; - abnormal hematological laboratory test results outside the reference range during previous physical examination within one year: blood routine indicators (white blood cell count, hemoglobin, platelet count), coagulation function test (prothrombin time pt, activated partial prothrombin time aptt, fibrinogen fib, thrombin time tt, international standardized ratio inr, d-dimer), other indicators (blood glucose, platelet factor 4 hit elisa, erythrocyte sedimentation rate); - history of alcohol or drug abuse; - receipt of blood products within in the past 3 months; - receipt of other investigational drugs in the past 30 days; - receipt of attenuated live vaccines in the past 14 days; - receipt of inactivated or subunit vaccines in the past 7 days; - axillary temperature >37.0°c; - already pregnant (including a positive urine pregnancy test) or are breastfeeding, planning to get pregnant within 3 months; - history of taking aspirin drugs and other drugs that affect blood coagulation; - according to the investigator's judgment, the subject has any other factors that are not suitable for participating in the clinical trial.