inclusion criteria: 1. male or female patients aged ≥18 years 2. women of childbearing potential must have a negative serum pregnancy test to confirm eligibility 3. provision of signed written informed consent from the patient or patient's legally acceptable representative 4. sars-cov-2 infection confirmed by rt-pcr laboratory test (which may include results from a test that was performed prior to hospital admission if, in the opinion of the investigator, it is relevant to ongoing covid-19) 5. meet berlin definition for moderate - severe ards 1. bilateral opacities - not fully explained by effusions, lobar/lung collapse, or nodules 2. respiratory failure not fully explained by cardiac failure or fluid overload. 3. pao2/fio2 ≤200 mmhg with peep ≥5 cmh2o 6. patient requires intubation or is currently intubated and has been for ≤48 hours

inclusion criteria: 1. male or female patients aged ≥18 years 2. women of childbearing potential must have a negative serum pregnancy test to confirm eligibility 3. provision of signed written informed consent from the patient or patient's legally acceptable representative 4. sars-cov-2 infection confirmed by rt-pcr laboratory test (which may include results from a test that was performed prior to hospital admission if, in the opinion of the investigator, it is relevant to ongoing covid-19) 5. meet berlin definition for moderate - severe ards 1. bilateral opacities - not fully explained by effusions, lobar/lung collapse, or nodules 2. respiratory failure not fully explained by cardiac failure or fluid overload. 3. pao2/fio2 ≤200 mmhg with peep ≥5 cmh2o 6. patient requires intubation or is currently intubated and has been for ≤48 hours

inclusion criteria: male or female patients aged ≥18 years women of childbearing potential must have a negative serum pregnancy test to confirm eligibility provision of signed written informed consent from the patient or patient's legally acceptable representative sars-cov-2 infection confirmed by rt-pcr laboratory test (which may include results from a test that was performed prior to hospital admission if, in the opinion of the investigator, it is relevant to ongoing covid-19) meet berlin definition for moderate - severe ards bilateral opacities - not fully explained by effusions, lobar/lung collapse, or nodules respiratory failure not fully explained by cardiac failure or fluid overload. pao2/fio2 ≤200 mmhg with peep ≥5 cmh2o patient requires intubation or is currently intubated and has been for ≤48 hours

inclusion criteria: male or female patients aged ≥18 years women of childbearing potential must have a negative serum pregnancy test to confirm eligibility provision of signed written informed consent from the patient or patient's legally acceptable representative sars-cov-2 infection confirmed by rt-pcr laboratory test (which may include results from a test that was performed prior to hospital admission if, in the opinion of the investigator, it is relevant to ongoing covid-19) meet berlin definition for moderate - severe ards bilateral opacities - not fully explained by effusions, lobar/lung collapse, or nodules respiratory failure not fully explained by cardiac failure or fluid overload. pao2/fio2 ≤200 mmhg with peep ≥5 cmh2o patient requires intubation or is currently intubated and has been for ≤48 hours

inclusion criteria: 1. male or female patients aged ≥18 years 2. women of childbearing potential must have a negative serum pregnancy test to confirm eligibility 3. provision of signed written informed consent from the patient or patient's legally acceptable representative 4. sars-cov-2 infection confirmed by rt-pcr laboratory test (which may include results from a test that was performed prior to hospital admission if, in the opinion of the investigator, it is relevant to ongoing covid-19) 5. meet berlin definition for moderate - severe ards 1. bilateral opacities - not fully explained by effusions, lobar/lung collapse, or nodules 2. respiratory failure not fully explained by cardiac failure or fluid overload. 3. pao2/fio2 ≤200 mmhg with peep ≥5 cmh2o 6. patient requires intubation or is currently intubated and has been for ≤48 hours

inclusion criteria: 1. male or female patients aged ≥18 years 2. women of childbearing potential must have a negative serum pregnancy test to confirm eligibility 3. provision of signed written informed consent from the patient or patient's legally acceptable representative 4. sars-cov-2 infection confirmed by rt-pcr laboratory test (which may include results from a test that was performed prior to hospital admission if, in the opinion of the investigator, it is relevant to ongoing covid-19) 5. meet berlin definition for moderate - severe ards 1. bilateral opacities - not fully explained by effusions, lobar/lung collapse, or nodules 2. respiratory failure not fully explained by cardiac failure or fluid overload. 3. pao2/fio2 ≤200 mmhg with peep ≥5 cmh2o 6. patient requires intubation or is currently intubated and has been for ≤48 hours