inclusion criteria: * we will include adult patients (≥18 years old) with severe and critical covid19 admitted to the covid19 mansoura university isolation hospital. we will include patients who are pcr-confirmed, clinically or radiologically diagnosed with covid19. cases are defined as severe or critical according to the who definition (19); where critical cases have ards, or sepsis, septic shock or pulmonary embolism, acute coronary syndrome, or acute stroke, while severe cases have the clinical signs of severe pneumonia and spo2 \<90% on room air, or rr \<30 breaths/min without any critical criteria.

inclusion criteria: * we will include adult patients (≥18 years old) with severe and critical covid19 admitted to the covid19 mansoura university isolation hospital. we will include patients who are pcr-confirmed, clinically or radiologically diagnosed with covid19. cases are defined as severe or critical according to the who definition (19); where critical cases have ards, or sepsis, septic shock or pulmonary embolism, acute coronary syndrome, or acute stroke, while severe cases have the clinical signs of severe pneumonia and spo2 \<90% on room air, or rr \<30 breaths/min without any critical criteria.

inclusion criteria: - we will include adult patients (≥18 years old) with severe and critical covid19 admitted to the covid19 mansoura university isolation hospital. we will include patients who are pcr-confirmed, clinically or radiologically diagnosed with covid19. cases are defined as severe or critical according to the who definition (19); where critical cases have ards, or sepsis, septic shock or pulmonary embolism, acute coronary syndrome, or acute stroke, while severe cases have the clinical signs of severe pneumonia and spo2 <90% on room air, or rr <30 breaths/min without any critical criteria.

inclusion criteria: - we will include adult patients (≥18 years old) with severe and critical covid19 admitted to the covid19 mansoura university isolation hospital. we will include patients who are pcr-confirmed, clinically or radiologically diagnosed with covid19. cases are defined as severe or critical according to the who definition (19); where critical cases have ards, or sepsis, septic shock or pulmonary embolism, acute coronary syndrome, or acute stroke, while severe cases have the clinical signs of severe pneumonia and spo2 <90% on room air, or rr <30 breaths/min without any critical criteria.