inclusion criteria: * 1. male or female ≥18 years of age * 2. individuals are willing and able to comply with study requirements, including all scheduled visits, vaccinations, laboratory tests and other study procedures. * 3.individuals are willing and able to give an informed consent, prior to screening * 4. healthy participants or participants with pre-existing medical conditions\* who are in a stable medical condition. (\*a stable medical condition is defined as disease not requiring significant change or hospitalization for worsening disease during the 3 months before enrollment.) * 5. female participants of childbearing potential may be enrolled in the study, if the participant has practiced adequate contraception for 30 days prior to vaccination and has a negative pregnancy test on the day of vaccination and has agreed to continue adequate contraception for 3 months after the last vaccination * 6. male participants must agree to employ acceptable contraception from the day of the first dose of the study vaccine until 6 months after the last dose of the study vaccine and also refrain from donating sperm during this period.

inclusion criteria: * 1. male or female ≥18 years of age * 2. individuals are willing and able to comply with study requirements, including all scheduled visits, vaccinations, laboratory tests and other study procedures. * 3.individuals are willing and able to give an informed consent, prior to screening * 4. healthy participants or participants with pre-existing medical conditions\* who are in a stable medical condition. (\*a stable medical condition is defined as disease not requiring significant change or hospitalization for worsening disease during the 3 months before enrollment.) * 5. female participants of childbearing potential may be enrolled in the study, if the participant has practiced adequate contraception for 30 days prior to vaccination and has a negative pregnancy test on the day of vaccination and has agreed to continue adequate contraception for 3 months after the last vaccination * 6. male participants must agree to employ acceptable contraception from the day of the first dose of the study vaccine until 6 months after the last dose of the study vaccine and also refrain from donating sperm during this period.

inclusion criteria: - 1. male or female ≥18 years of age - 2. individuals are willing and able to comply with study requirements, including all scheduled visits, vaccinations, laboratory tests and other study procedures. - 3.individuals are willing and able to give an informed consent, prior to screening - 4. healthy participants or participants with pre-existing medical conditions* who are in a stable medical condition. (*a stable medical condition is defined as disease not requiring significant change or hospitalization for worsening disease during the 3 months before enrollment.) - 5. female participants of childbearing potential may be enrolled in the study, if the participant has practiced adequate contraception for 30 days prior to vaccination and has a negative pregnancy test on the day of vaccination and has agreed to continue adequate contraception for 3 months after the last vaccination - 6. male participants must agree to employ acceptable contraception from the day of the first dose of the study vaccine until 6 months after the last dose of the study vaccine and also refrain from donating sperm during this period.

inclusion criteria: - 1. male or female ≥18 years of age - 2. individuals are willing and able to comply with study requirements, including all scheduled visits, vaccinations, laboratory tests and other study procedures. - 3.individuals are willing and able to give an informed consent, prior to screening - 4. healthy participants or participants with pre-existing medical conditions* who are in a stable medical condition. (*a stable medical condition is defined as disease not requiring significant change or hospitalization for worsening disease during the 3 months before enrollment.) - 5. female participants of childbearing potential may be enrolled in the study, if the participant has practiced adequate contraception for 30 days prior to vaccination and has a negative pregnancy test on the day of vaccination and has agreed to continue adequate contraception for 3 months after the last vaccination - 6. male participants must agree to employ acceptable contraception from the day of the first dose of the study vaccine until 6 months after the last dose of the study vaccine and also refrain from donating sperm during this period.