* subjects to whom any of the following applies will be excluded from the study: 1. pregnancy or of childbearing age without a highly effective method or at least two forms of effective contraception and/ or abstinence for the duration of study. highly effective methods of contraception (contraception with \< 1% failure rate) are: hormonal contraceptives (e.g. combined oral contraceptives, patch, vaginal ring, injectables, and implants); intrauterine device (iud) or intrauterine system (ius); vasectomy and tubal ligation. effective methods of contraception may include barrier methods of contraception (e.g., male condom, female condom, cervical cap, diaphragm, contraceptive sponge). 2. breastfeeding females. 3. evidence of active thromboembolic disorder - defined by those receiving parenteral anticoagulant or thrombolytic therapy. 4. pre-existing evidence of unstable angina and myocardial infraction during the previous month, contraindications to the 6mwt. 5. subject, who in the opinion of the investigator, is unsuitable to participate.

* subjects to whom any of the following applies will be excluded from the study: 1. pregnancy or of childbearing age without a highly effective method or at least two forms of effective contraception and/ or abstinence for the duration of study. highly effective methods of contraception (contraception with \< 1% failure rate) are: hormonal contraceptives (e.g. combined oral contraceptives, patch, vaginal ring, injectables, and implants); intrauterine device (iud) or intrauterine system (ius); vasectomy and tubal ligation. effective methods of contraception may include barrier methods of contraception (e.g., male condom, female condom, cervical cap, diaphragm, contraceptive sponge). 2. breastfeeding females. 3. evidence of active thromboembolic disorder - defined by those receiving parenteral anticoagulant or thrombolytic therapy. 4. pre-existing evidence of unstable angina and myocardial infraction during the previous month, contraindications to the 6mwt. 5. subject, who in the opinion of the investigator, is unsuitable to participate.

subjects to whom any of the following applies will be excluded from the study: pregnancy or of childbearing age without a highly effective method or at least two forms of effective contraception and/ or abstinence for the duration of study. highly effective methods of contraception (contraception with < 1% failure rate) are: hormonal contraceptives (e.g. combined oral contraceptives, patch, vaginal ring, injectables, and implants); intrauterine device (iud) or intrauterine system (ius); vasectomy and tubal ligation. effective methods of contraception may include barrier methods of contraception (e.g., male condom, female condom, cervical cap, diaphragm, contraceptive sponge). breastfeeding females. evidence of active thromboembolic disorder - defined by those receiving parenteral anticoagulant or thrombolytic therapy. pre-existing evidence of unstable angina and myocardial infraction during the previous month, contraindications to the 6mwt. subject, who in the opinion of the investigator, is unsuitable to participate.

subjects to whom any of the following applies will be excluded from the study: pregnancy or of childbearing age without a highly effective method or at least two forms of effective contraception and/ or abstinence for the duration of study. highly effective methods of contraception (contraception with < 1% failure rate) are: hormonal contraceptives (e.g. combined oral contraceptives, patch, vaginal ring, injectables, and implants); intrauterine device (iud) or intrauterine system (ius); vasectomy and tubal ligation. effective methods of contraception may include barrier methods of contraception (e.g., male condom, female condom, cervical cap, diaphragm, contraceptive sponge). breastfeeding females. evidence of active thromboembolic disorder - defined by those receiving parenteral anticoagulant or thrombolytic therapy. pre-existing evidence of unstable angina and myocardial infraction during the previous month, contraindications to the 6mwt. subject, who in the opinion of the investigator, is unsuitable to participate.

- subjects to whom any of the following applies will be excluded from the study: 1. pregnancy or of childbearing age without a highly effective method or at least two forms of effective contraception and/ or abstinence for the duration of study. highly effective methods of contraception (contraception with < 1% failure rate) are: hormonal contraceptives (e.g. combined oral contraceptives, patch, vaginal ring, injectables, and implants); intrauterine device (iud) or intrauterine system (ius); vasectomy and tubal ligation. effective methods of contraception may include barrier methods of contraception (e.g., male condom, female condom, cervical cap, diaphragm, contraceptive sponge). 2. breastfeeding females. 3. evidence of active thromboembolic disorder - defined by those receiving parenteral anticoagulant or thrombolytic therapy. 4. pre-existing evidence of unstable angina and myocardial infraction during the previous month, contraindications to the 6mwt. 5. subject, who in the opinion of the investigator, is unsuitable to participate.

- subjects to whom any of the following applies will be excluded from the study: 1. pregnancy or of childbearing age without a highly effective method or at least two forms of effective contraception and/ or abstinence for the duration of study. highly effective methods of contraception (contraception with < 1% failure rate) are: hormonal contraceptives (e.g. combined oral contraceptives, patch, vaginal ring, injectables, and implants); intrauterine device (iud) or intrauterine system (ius); vasectomy and tubal ligation. effective methods of contraception may include barrier methods of contraception (e.g., male condom, female condom, cervical cap, diaphragm, contraceptive sponge). 2. breastfeeding females. 3. evidence of active thromboembolic disorder - defined by those receiving parenteral anticoagulant or thrombolytic therapy. 4. pre-existing evidence of unstable angina and myocardial infraction during the previous month, contraindications to the 6mwt. 5. subject, who in the opinion of the investigator, is unsuitable to participate.