inclusion criteria: * adult, hospitalized severe covid-19 patients; both genders; given informed consent (covid-19 infection confirmed by pcr, severe illness is defined as patients with spo2 ≤94% on room air, including patients on supplemental oxygen).

inclusion criteria: * adult, hospitalized severe covid-19 patients; both genders; given informed consent (covid-19 infection confirmed by pcr, severe illness is defined as patients with spo2 ≤94% on room air, including patients on supplemental oxygen).

inclusion criteria: - adult, hospitalized severe covid-19 patients; both genders; given informed consent (covid-19 infection confirmed by pcr, severe illness is defined as patients with spo2 ≤94% on room air, including patients on supplemental oxygen).

inclusion criteria: - adult, hospitalized severe covid-19 patients; both genders; given informed consent (covid-19 infection confirmed by pcr, severe illness is defined as patients with spo2 ≤94% on room air, including patients on supplemental oxygen).