inclusion criteria: 1. written informed consent for participation in the study 2. male and female age 18 or more at the time of signing the informed consent 3. sars-cov-2 infection confirmed by real-time reverse transcription polymerase chain reaction (rt-pcr) 4. covid-19 pneumonia with a typical radiological changes 5. pao2/fio2 ratio less than or equal to 300 6. covid-19 pneumonia in cytokine storm with elevated serum level of interleukin-6

inclusion criteria: 1. written informed consent for participation in the study 2. male and female age 18 or more at the time of signing the informed consent 3. sars-cov-2 infection confirmed by real-time reverse transcription polymerase chain reaction (rt-pcr) 4. covid-19 pneumonia with a typical radiological changes 5. pao2/fio2 ratio less than or equal to 300 6. covid-19 pneumonia in cytokine storm with elevated serum level of interleukin-6

inclusion criteria: written informed consent for participation in the study male and female age 18 or more at the time of signing the informed consent sars-cov-2 infection confirmed by real-time reverse transcription polymerase chain reaction (rt-pcr) covid-19 pneumonia with a typical radiological changes pao2/fio2 ratio less than or equal to 300 covid-19 pneumonia in cytokine storm with elevated serum level of interleukin-6

inclusion criteria: written informed consent for participation in the study male and female age 18 or more at the time of signing the informed consent sars-cov-2 infection confirmed by real-time reverse transcription polymerase chain reaction (rt-pcr) covid-19 pneumonia with a typical radiological changes pao2/fio2 ratio less than or equal to 300 covid-19 pneumonia in cytokine storm with elevated serum level of interleukin-6

inclusion criteria: 1. written informed consent for participation in the study 2. male and female age 18 or more at the time of signing the informed consent 3. sars-cov-2 infection confirmed by real-time reverse transcription polymerase chain reaction (rt-pcr) 4. covid-19 pneumonia with a typical radiological changes 5. pao2/fio2 ratio less than or equal to 300 6. covid-19 pneumonia in cytokine storm with elevated serum level of interleukin-6

inclusion criteria: 1. written informed consent for participation in the study 2. male and female age 18 or more at the time of signing the informed consent 3. sars-cov-2 infection confirmed by real-time reverse transcription polymerase chain reaction (rt-pcr) 4. covid-19 pneumonia with a typical radiological changes 5. pao2/fio2 ratio less than or equal to 300 6. covid-19 pneumonia in cytokine storm with elevated serum level of interleukin-6