subjects meeting any of the following criteria are not eligible for inclusion in this study. 1. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of troponin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) 2. chronic systolic heart failure with ef\<35% 3. age \< 18 years-old 4. uncontrolled systemic bacterial or fungal infection 5. concomitant viral infection (e.g., influenza or other respiratory virus) 6. pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. 7. on mechanical circulatory support 8. on mechanical ventilation for greater than 48 hours 9. resuscitated cardiac arrest 10. has a known hypersensitivity to canakinumab or any of its excipients 11. neutrophil count \<1000/mm3 12. has a history of myeloproliferative disorder or active malignancy receiving chemotherapy 13. known active tuberculosis or history of incompletely treated tuberculosis 14. current treatment with immunosuppressive agents 15. chronic prednisone use \>10 mg/daily (for more than 3 weeks prior to admission) 16. has a history of solid-organ or bone marrow transplant 17. severe pre-existing liver disease with clinically significant portal hypertension 18. end-stage renal disease on chronic renal replacement therapy 19. enrollment in another investigational study using immunosuppressive therapy 20. in the opinion of the investigator and clinical team, should not participate in the study 21. if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. 22. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: * total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception * female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment * male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject * use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate \<1%), for example hormone vaginal ring or transdermal hormone contraception

subjects meeting any of the following criteria are not eligible for inclusion in this study. 1. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of troponin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) 2. chronic systolic heart failure with ef\<35% 3. age \< 18 years-old 4. uncontrolled systemic bacterial or fungal infection 5. concomitant viral infection (e.g., influenza or other respiratory virus) 6. pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. 7. on mechanical circulatory support 8. on mechanical ventilation for greater than 48 hours 9. resuscitated cardiac arrest 10. has a known hypersensitivity to canakinumab or any of its excipients 11. neutrophil count \<1000/mm3 12. has a history of myeloproliferative disorder or active malignancy receiving chemotherapy 13. known active tuberculosis or history of incompletely treated tuberculosis 14. current treatment with immunosuppressive agents 15. chronic prednisone use \>10 mg/daily (for more than 3 weeks prior to admission) 16. has a history of solid-organ or bone marrow transplant 17. severe pre-existing liver disease with clinically significant portal hypertension 18. end-stage renal disease on chronic renal replacement therapy 19. enrollment in another investigational study using immunosuppressive therapy 20. in the opinion of the investigator and clinical team, should not participate in the study 21. if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. 22. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: * total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception * female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment * male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject * use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate \<1%), for example hormone vaginal ring or transdermal hormone contraception

subjects meeting any of the following criteria are not eligible for inclusion in this study. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of troponin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) chronic systolic heart failure with ef<35% age < 18 years-old uncontrolled systemic bacterial or fungal infection concomitant viral infection (e.g., influenza or other respiratory virus) pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. on mechanical circulatory support on mechanical ventilation for greater than 48 hours resuscitated cardiac arrest has a known hypersensitivity to canakinumab or any of its excipients neutrophil count <1000/mm3 has a history of myeloproliferative disorder or active malignancy receiving chemotherapy known active tuberculosis or history of incompletely treated tuberculosis current treatment with immunosuppressive agents chronic prednisone use >10 mg/daily (for more than 3 weeks prior to admission) has a history of solid-organ or bone marrow transplant severe pre-existing liver disease with clinically significant portal hypertension end-stage renal disease on chronic renal replacement therapy enrollment in another investigational study using immunosuppressive therapy in the opinion of the investigator and clinical team, should not participate in the study if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception

subjects meeting any of the following criteria are not eligible for inclusion in this study. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of troponin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) chronic systolic heart failure with ef<35% age < 18 years-old uncontrolled systemic bacterial or fungal infection concomitant viral infection (e.g., influenza or other respiratory virus) pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. on mechanical circulatory support on mechanical ventilation for greater than 48 hours resuscitated cardiac arrest has a known hypersensitivity to canakinumab or any of its excipients neutrophil count <1000/mm3 has a history of myeloproliferative disorder or active malignancy receiving chemotherapy known active tuberculosis or history of incompletely treated tuberculosis current treatment with immunosuppressive agents chronic prednisone use >10 mg/daily (for more than 3 weeks prior to admission) has a history of solid-organ or bone marrow transplant severe pre-existing liver disease with clinically significant portal hypertension end-stage renal disease on chronic renal replacement therapy enrollment in another investigational study using immunosuppressive therapy in the opinion of the investigator and clinical team, should not participate in the study if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception

subjects meeting any of the following criteria are not eligible for inclusion in this study. 1. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of troponin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) 2. chronic systolic heart failure with ef<35% 3. age < 18 years-old 4. uncontrolled systemic bacterial or fungal infection 5. concomitant viral infection (e.g., influenza or other respiratory virus) 6. pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. 7. on mechanical circulatory support 8. on mechanical ventilation for greater than 48 hours 9. resuscitated cardiac arrest 10. has a known hypersensitivity to canakinumab or any of its excipients 11. neutrophil count <1000/mm3 12. has a history of myeloproliferative disorder or active malignancy receiving chemotherapy 13. known active tuberculosis or history of incompletely treated tuberculosis 14. current treatment with immunosuppressive agents 15. chronic prednisone use >10 mg/daily (for more than 3 weeks prior to admission) 16. has a history of solid-organ or bone marrow transplant 17. severe pre-existing liver disease with clinically significant portal hypertension 18. end-stage renal disease on chronic renal replacement therapy 19. enrollment in another investigational study using immunosuppressive therapy 20. in the opinion of the investigator and clinical team, should not participate in the study 21. if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. 22. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: - total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception - female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment - male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject - use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception

subjects meeting any of the following criteria are not eligible for inclusion in this study. 1. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of troponin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) 2. chronic systolic heart failure with ef<35% 3. age < 18 years-old 4. uncontrolled systemic bacterial or fungal infection 5. concomitant viral infection (e.g., influenza or other respiratory virus) 6. pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. 7. on mechanical circulatory support 8. on mechanical ventilation for greater than 48 hours 9. resuscitated cardiac arrest 10. has a known hypersensitivity to canakinumab or any of its excipients 11. neutrophil count <1000/mm3 12. has a history of myeloproliferative disorder or active malignancy receiving chemotherapy 13. known active tuberculosis or history of incompletely treated tuberculosis 14. current treatment with immunosuppressive agents 15. chronic prednisone use >10 mg/daily (for more than 3 weeks prior to admission) 16. has a history of solid-organ or bone marrow transplant 17. severe pre-existing liver disease with clinically significant portal hypertension 18. end-stage renal disease on chronic renal replacement therapy 19. enrollment in another investigational study using immunosuppressive therapy 20. in the opinion of the investigator and clinical team, should not participate in the study 21. if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. 22. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: - total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception - female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment - male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject - use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception

subjects meeting any of the following criteria are not eligible for inclusion in this study. 1. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of tropnonin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) 2. chronic systolic heart failure with ef<35% 3. age < 18 years-old 4. uncontrolled systemic bacterial or fungal infection 5. concomitant viral infection (e.g., influenza or other respiratory virus) 6. pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. 7. on mechanical circulatory support 8. on mechanical ventilation for greater than 48 hours 9. resuscitated cardiac arrest 10. has a known hypersensitivity to canakinumab or any of its excipients 11. neutrophil count <1000/mm3 12. has a history of myeloproliferative disorder or active malignancy receiving chemotherapy 13. known active tuberculosis or history of incompletely treated tuberculosis 14. current treatment with immunosuppressive agents 15. chronic prednisone use >10 mg/daily (for more than 3 weeks prior to admission) 16. has a history of solid-organ or bone marrow transplant 17. severe pre-existing liver disease with clinically significant portal hypertension 18. end-stage renal disease on chronic renal replacement therapy 19. enrollment in another investigational study using immunosuppressive therapy 20. in the opinion of the investigator and clinical team, should not participate in the study 21. if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. 22. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: - total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception - female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment - male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject - use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception

subjects meeting any of the following criteria are not eligible for inclusion in this study. 1. alternative explanation for acute cardiac injury (type i or type ii mi according to 4th universal definition of myocardial infarction, which in addition to a rise and fall of tropnonin above the 99th percentile upper reference limit, includes symptoms of acute myocardial ischemia, new ischemic ecg changes, development of pathologic q waves, and imaging evidence of damage in a pattern consistent with an ischemic etiology) 2. chronic systolic heart failure with ef<35% 3. age < 18 years-old 4. uncontrolled systemic bacterial or fungal infection 5. concomitant viral infection (e.g., influenza or other respiratory virus) 6. pregnant. breast-feeding women are eligible with the decision to continue or discontinue breast-feeding during therapy taking into account the risk of infant exposure, the benefits of breast-feeding to the infant, and benefits of treatment to the mother. 7. on mechanical circulatory support 8. on mechanical ventilation for greater than 48 hours 9. resuscitated cardiac arrest 10. has a known hypersensitivity to canakinumab or any of its excipients 11. neutrophil count <1000/mm3 12. has a history of myeloproliferative disorder or active malignancy receiving chemotherapy 13. known active tuberculosis or history of incompletely treated tuberculosis 14. current treatment with immunosuppressive agents 15. chronic prednisone use >10 mg/daily (for more than 3 weeks prior to admission) 16. has a history of solid-organ or bone marrow transplant 17. severe pre-existing liver disease with clinically significant portal hypertension 18. end-stage renal disease on chronic renal replacement therapy 19. enrollment in another investigational study using immunosuppressive therapy 20. in the opinion of the investigator and clinical team, should not participate in the study 21. if male and sexually active, must have documented vasectomy or must practice birth control and not donate sperm during the study and for 3 months after study drug administration. 22. women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing of investigational drug. such methods include: - total abstinence (when this is in line with the preferred and usual lifestyle of the subject. periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception - female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or bilateral tubal ligation at least six weeks before taking study treatment. in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment - male sterilization (at least 6 months prior to screening). for female subjects on the study, the vasectomized male partner should be the sole partner for that subject - use of oral, (estrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device (iud) or intrauterine system (ius), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception