* aggravated allergic history, drug intolerance, including hypersensitivity to any of the components of the study drug, as well as a history of serious adverse events during vaccine administration (such as allergic reactions, respiratory failure, angioedema, abdominal pain). * acute illness with a fever (body temperature ≥37.1°c) at the time of screening/randomization. * chronic alcohol and/or drug use in history. * clinically significant deviations from normal values during laboratory and/or imaging at screening. * women with a positive urine pregnancy test. * simultaneous treatment with immunosuppressive drugs, including corticosteroids (2 weeks) 4 weeks prior to study drug administration. * acute or chronic clinically significant lesions of the lungs, cardiovascular system, gastrointestinal tract, liver, blood system, skin, endocrine, neurological and psychiatric diseases or impaired renal function (asthma, diabetes, thyroid disease, arrhythmia, myocardial infarction, severe hypertension not controlled by drugs, etc.), identified based on medical history, physical examination or clinical laboratory tests that, according to the researcher, may affect the study result. * disruption of platelets or other blood clotting disorders, which may cause contraindications to intramuscular administration. * leukemia or neoplasm in history. * persons with autoimmune diseases. * volunteers who received antiviral drugs, immunoglobulin's or blood transfusions or any other investigational drug within 4 weeks prior to study drug administration; * volunteers who received anti-inflammatory drugs 2 days before study drug * administration; * participation in any other clinical research within the last 3 months; * volunteers with a concern that they will not comply with the study requirements, or persons with severe physical or mental disabilities that may affect the completion of the study; * negative pcr results for coronavirus sars-cov-2; * according to the results of a chest x-ray, there is no pathological process in the lungs; * voluntary refusal to study; * vulnerable volunteers of research.

* aggravated allergic history, drug intolerance, including hypersensitivity to any of the components of the study drug, as well as a history of serious adverse events during vaccine administration (such as allergic reactions, respiratory failure, angioedema, abdominal pain). * acute illness with a fever (body temperature ≥37.1°c) at the time of screening/randomization. * chronic alcohol and/or drug use in history. * clinically significant deviations from normal values during laboratory and/or imaging at screening. * women with a positive urine pregnancy test. * simultaneous treatment with immunosuppressive drugs, including corticosteroids (2 weeks) 4 weeks prior to study drug administration. * acute or chronic clinically significant lesions of the lungs, cardiovascular system, gastrointestinal tract, liver, blood system, skin, endocrine, neurological and psychiatric diseases or impaired renal function (asthma, diabetes, thyroid disease, arrhythmia, myocardial infarction, severe hypertension not controlled by drugs, etc.), identified based on medical history, physical examination or clinical laboratory tests that, according to the researcher, may affect the study result. * disruption of platelets or other blood clotting disorders, which may cause contraindications to intramuscular administration. * leukemia or neoplasm in history. * persons with autoimmune diseases. * volunteers who received antiviral drugs, immunoglobulin's or blood transfusions or any other investigational drug within 4 weeks prior to study drug administration; * volunteers who received anti-inflammatory drugs 2 days before study drug * administration; * participation in any other clinical research within the last 3 months; * volunteers with a concern that they will not comply with the study requirements, or persons with severe physical or mental disabilities that may affect the completion of the study; * negative pcr results for coronavirus sars-cov-2; * according to the results of a chest x-ray, there is no pathological process in the lungs; * voluntary refusal to study; * vulnerable volunteers of research.

- aggravated allergic history, drug intolerance, including hypersensitivity to any of the components of the study drug, as well as a history of serious adverse events during vaccine administration (such as allergic reactions, respiratory failure, angioedema, abdominal pain). - acute illness with a fever (body temperature ≥37.1°c) at the time of screening/randomization. - chronic alcohol and/or drug use in history. - clinically significant deviations from normal values during laboratory and/or imaging at screening. - women with a positive urine pregnancy test. - simultaneous treatment with immunosuppressive drugs, including corticosteroids (2 weeks) 4 weeks prior to study drug administration. - acute or chronic clinically significant lesions of the lungs, cardiovascular system, gastrointestinal tract, liver, blood system, skin, endocrine, neurological and psychiatric diseases or impaired renal function (asthma, diabetes, thyroid disease, arrhythmia, myocardial infarction, severe hypertension not controlled by drugs, etc.), identified based on medical history, physical examination or clinical laboratory tests that, according to the researcher, may affect the study result. - disruption of platelets or other blood clotting disorders, which may cause contraindications to intramuscular administration. - leukemia or neoplasm in history. - persons with autoimmune diseases. - volunteers who received antiviral drugs, immunoglobulin's or blood transfusions or any other investigational drug within 4 weeks prior to study drug administration; - volunteers who received anti-inflammatory drugs 2 days before study drug - administration; - participation in any other clinical research within the last 3 months; - volunteers with a concern that they will not comply with the study requirements, or persons with severe physical or mental disabilities that may affect the completion of the study; - negative pcr results for coronavirus sars-cov-2; - according to the results of a chest x-ray, there is no pathological process in the lungs; - voluntary refusal to study; - vulnerable volunteers of research.

- aggravated allergic history, drug intolerance, including hypersensitivity to any of the components of the study drug, as well as a history of serious adverse events during vaccine administration (such as allergic reactions, respiratory failure, angioedema, abdominal pain). - acute illness with a fever (body temperature ≥37.1°c) at the time of screening/randomization. - chronic alcohol and/or drug use in history. - clinically significant deviations from normal values during laboratory and/or imaging at screening. - women with a positive urine pregnancy test. - simultaneous treatment with immunosuppressive drugs, including corticosteroids (2 weeks) 4 weeks prior to study drug administration. - acute or chronic clinically significant lesions of the lungs, cardiovascular system, gastrointestinal tract, liver, blood system, skin, endocrine, neurological and psychiatric diseases or impaired renal function (asthma, diabetes, thyroid disease, arrhythmia, myocardial infarction, severe hypertension not controlled by drugs, etc.), identified based on medical history, physical examination or clinical laboratory tests that, according to the researcher, may affect the study result. - disruption of platelets or other blood clotting disorders, which may cause contraindications to intramuscular administration. - leukemia or neoplasm in history. - persons with autoimmune diseases. - volunteers who received antiviral drugs, immunoglobulin's or blood transfusions or any other investigational drug within 4 weeks prior to study drug administration; - volunteers who received anti-inflammatory drugs 2 days before study drug - administration; - participation in any other clinical research within the last 3 months; - volunteers with a concern that they will not comply with the study requirements, or persons with severe physical or mental disabilities that may affect the completion of the study; - negative pcr results for coronavirus sars-cov-2; - according to the results of a chest x-ray, there is no pathological process in the lungs; - voluntary refusal to study; - vulnerable volunteers of research.