inclusion criteria: * healthy subjects aged 3 years old and above * medical history and physical examination of the subject confirms the subject is in a healthy condition and is approved by the investigator * female subjects of childbearing age who are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. * the subject must be able and willing to complete the whole immunization schedule of the study and be able to follow up study procedures for 6 months. * with self-ability to understand the study procedures, the informed consent \& voluntarily sign an informed consent/ assent form. legal authority or parents/guardians of minors 3-17 years should sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: * healthy subjects aged 3 years old and above * medical history and physical examination of the subject confirms the subject is in a healthy condition and is approved by the investigator * female subjects of childbearing age who are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. * the subject must be able and willing to complete the whole immunization schedule of the study and be able to follow up study procedures for 6 months. * with self-ability to understand the study procedures, the informed consent \& voluntarily sign an informed consent/ assent form. legal authority or parents/guardians of minors 3-17 years should sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: - healthy subjects aged 3 years old and above - medical history and physical examination of the subject confirms the subject is in a healthy condition and is approved by the investigator - female subjects of childbearing age who are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. - the subject must be able and willing to complete the whole immunization schedule of the study and be able to follow up study procedures for 6 months. - with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent/ assent form. legal authority or parents/guardians of minors 3-17 years should sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: - healthy subjects aged 3 years old and above - medical history and physical examination of the subject confirms the subject is in a healthy condition and is approved by the investigator - female subjects of childbearing age who are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. - the subject must be able and willing to complete the whole immunization schedule of the study and be able to follow up study procedures for 6 months. - with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent/ assent form. legal authority or parents/guardians of minors 3-17 years should sign an informed consent form and be able to comply with the requirements of the clinical study protocol.