inclusion criteria: 1. patients of both sexes, 18-90 years of age. 2. patient requiring oxygen therapy, spo2 \<94%. 3. confirmed covid-19 infection. 4. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. 5. documented informed consent according to ich-gcp and national regulations.

inclusion criteria: 1. patients of both sexes, 18-90 years of age. 2. patient requiring oxygen therapy, spo2 \<94%. 3. confirmed covid-19 infection. 4. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. 5. documented informed consent according to ich-gcp and national regulations.

inclusion criteria: patients of both sexes, 18-90 years of age. patient requiring oxygen therapy, spo2 <94%. confirmed covid-19 infection. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. documented informed consent according to ich-gcp and national regulations.

inclusion criteria: patients of both sexes, 18-90 years of age. patient requiring oxygen therapy, spo2 <94%. confirmed covid-19 infection. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. documented informed consent according to ich-gcp and national regulations.

inclusion criteria: 1. patients of both sexes, 18-90 years of age. 2. patient requiring oxygen therapy, spo2 <94%. 3. confirmed covid-19 infection. 4. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. 5. documented informed consent according to ich-gcp and national regulations.

inclusion criteria: 1. patients of both sexes, 18-90 years of age. 2. patient requiring oxygen therapy, spo2 <94%. 3. confirmed covid-19 infection. 4. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. 5. documented informed consent according to ich-gcp and national regulations.

inclusion criteria: 1. patients of both sexes, 18-90 years of age. 2. patient requiring oxygen therapy, spo2 <94% 3. confirmed covid-19 infection. 4. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. 5. documented informed consent according to ich-gcp and national regulations.

inclusion criteria: 1. patients of both sexes, 18-90 years of age. 2. patient requiring oxygen therapy, spo2 <94% 3. confirmed covid-19 infection. 4. at least one risk factor for increased mortality in the course of covid-19: currently published in the literature e.g. smoking, hypertension, diabetes, cardiovascular disease. 5. documented informed consent according to ich-gcp and national regulations.