* the patients who are diagnosed as critically ill cases or participating in other clinical trials * women who are pregnant or lactating * alt/ast \> 5 times upper limit of normal (uln), neutrophils counts \< 0.5×109/l, platelets counts\< 50×109/l * patients diagnosed with rheumatoid immune-related diseases * patients who take long-term oral anti-rejection drugs or immunomodulatory drugs * hypersensitive reaction to nicotinamide or any auxiliary materials * patients with active tuberculosis or combined with bacterial and fungal infections * patients undergoing organ transplant * patients with mental disorders.

* the patients who are diagnosed as critically ill cases or participating in other clinical trials * women who are pregnant or lactating * alt/ast \> 5 times upper limit of normal (uln), neutrophils counts \< 0.5×109/l, platelets counts\< 50×109/l * patients diagnosed with rheumatoid immune-related diseases * patients who take long-term oral anti-rejection drugs or immunomodulatory drugs * hypersensitive reaction to nicotinamide or any auxiliary materials * patients with active tuberculosis or combined with bacterial and fungal infections * patients undergoing organ transplant * patients with mental disorders.

- the patients who are diagnosed as critically ill cases or participating in other clinical trials - women who are pregnant or lactating - alt/ast > 5 times upper limit of normal (uln), neutrophils counts < 0.5×109/l, platelets counts< 50×109/l - patients diagnosed with rheumatoid immune-related diseases - patients who take long-term oral anti-rejection drugs or immunomodulatory drugs - hypersensitive reaction to nicotinamide or any auxiliary materials - patients with active tuberculosis or combined with bacterial and fungal infections - patients undergoing organ transplant - patients with mental disorders.

- the patients who are diagnosed as critically ill cases or participating in other clinical trials - women who are pregnant or lactating - alt/ast > 5 times upper limit of normal (uln), neutrophils counts < 0.5×109/l, platelets counts< 50×109/l - patients diagnosed with rheumatoid immune-related diseases - patients who take long-term oral anti-rejection drugs or immunomodulatory drugs - hypersensitive reaction to nicotinamide or any auxiliary materials - patients with active tuberculosis or combined with bacterial and fungal infections - patients undergoing organ transplant - patients with mental disorders.