inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. 2. age 18-80 years. 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate \> 23/min and \< 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates \>25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh \> 300 u/l or what is the upper limit for normal per age ii. crp \>25 mg/l iii. ferritin \>500 ng/ml iv. lymphocytes \<800 cells/mm3 v. d-dimers \> 500ng/ml 4. willing and able to sign an informed consent.

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. 2. age 18-80 years. 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate \> 23/min and \< 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates \>25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh \> 300 u/l or what is the upper limit for normal per age ii. crp \>25 mg/l iii. ferritin \>500 ng/ml iv. lymphocytes \<800 cells/mm3 v. d-dimers \> 500ng/ml 4. willing and able to sign an informed consent.

inclusion criteria: a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. age 18-80 years. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh > 300 u/l or what is the upper limit for normal per age ii. crp >25 mg/l iii. ferritin >500 ng/ml iv. lymphocytes <800 cells/mm3 v. d-dimers > 500ng/ml willing and able to sign an informed consent.

inclusion criteria: a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. age 18-80 years. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh > 300 u/l or what is the upper limit for normal per age ii. crp >25 mg/l iii. ferritin >500 ng/ml iv. lymphocytes <800 cells/mm3 v. d-dimers > 500ng/ml willing and able to sign an informed consent.

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. 2. age 18-80 years. 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh > 300 u/l or what is the upper limit for normal per age ii. crp >25 mg/l iii. ferritin >500 ng/ml iv. lymphocytes <800 cells/mm3 v. d-dimers > 500ng/ml 4. willing and able to sign an informed consent.

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. 2. age 18-80 years. 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh > 300 u/l or what is the upper limit for normal per age ii. crp >25 mg/l iii. ferritin >500 ng/ml iv. lymphocytes <800 cells/mm3 v. d-dimers > 500ng/ml 4. willing and able to sign an informed consent.

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. 2. age 18-80 years. 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh > 300 u/l or what is the upper limit for normal per age ii. crp >25 mg/l iii. ferritin >500 ng/ml iv. lymphocytes <800 cells/mm3 v. d-dimers > 500ng/ml 4. willing and able to sign an informed consent.

inclusion criteria: 1. a covid-19 diagnosis confirmed with a sars-cov-2 infection positive polymerase chain reaction (pcr) within 30 days of screening. 2. age 18-80 years. 3. severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. clinical and imaging-based evaluation i. respiratory rate > 23/min and < 30/min ii. spo2 at room air ≤94% and ≥90% iii. bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission. b. evidence of an exacerbated inflammatory process i. ldh > 300 u/l or what is the upper limit for normal per age ii. crp >25 mg/l iii. ferritin >500 ng/ml iv. lymphocytes <800 cells/mm3 v. d-dimers > 500ng/ml 4. willing and able to sign an informed consent.