1. any concomitant illness that, based on the judgment of the investigator might affect the interpretation or the results of the study (i.e., immunodeficiency). 2. mechanically-ventilated patient or patient who will probably require icu admission or mechanical ventilation within 24 hours from enrolment, according to the investigator's judgment. 3. previous complete or partial vaccination for sars-cov-2. 4. pregnancy \[positive urine pregnancy test (women of childbearing potential only)\] or breastfeeding. 5. participation in any other interventional study in the last 30 days 6. active cancer.

1. any concomitant illness that, based on the judgment of the investigator might affect the interpretation or the results of the study (i.e., immunodeficiency). 2. mechanically-ventilated patient or patient who will probably require icu admission or mechanical ventilation within 24 hours from enrolment, according to the investigator's judgment. 3. previous complete or partial vaccination for sars-cov-2. 4. pregnancy \[positive urine pregnancy test (women of childbearing potential only)\] or breastfeeding. 5. participation in any other interventional study in the last 30 days 6. active cancer.

any concomitant illness that, based on the judgment of the investigator might affect the interpretation or the results of the study (i.e., immunodeficiency). mechanically-ventilated patient or patient who will probably require icu admission or mechanical ventilation within 24 hours from enrolment, according to the investigator's judgment. previous complete or partial vaccination for sars-cov-2. pregnancy [positive urine pregnancy test (women of childbearing potential only)] or breastfeeding. participation in any other interventional study in the last 30 days active cancer.

any concomitant illness that, based on the judgment of the investigator might affect the interpretation or the results of the study (i.e., immunodeficiency). mechanically-ventilated patient or patient who will probably require icu admission or mechanical ventilation within 24 hours from enrolment, according to the investigator's judgment. previous complete or partial vaccination for sars-cov-2. pregnancy [positive urine pregnancy test (women of childbearing potential only)] or breastfeeding. participation in any other interventional study in the last 30 days active cancer.

1. any concomitant illness that, based on the judgment of the investigator might affect the interpretation or the results of the study (i.e., immunodeficiency). 2. mechanically-ventilated patient or patient who will probably require icu admission or mechanical ventilation within 24 hours from enrolment, according to the investigator's judgment. 3. previous complete or partial vaccination for sars-cov-2. 4. pregnancy [positive urine pregnancy test (women of childbearing potential only)] or breastfeeding. 5. participation in any other interventional study in the last 30 days 6. active cancer.

1. any concomitant illness that, based on the judgment of the investigator might affect the interpretation or the results of the study (i.e., immunodeficiency). 2. mechanically-ventilated patient or patient who will probably require icu admission or mechanical ventilation within 24 hours from enrolment, according to the investigator's judgment. 3. previous complete or partial vaccination for sars-cov-2. 4. pregnancy [positive urine pregnancy test (women of childbearing potential only)] or breastfeeding. 5. participation in any other interventional study in the last 30 days 6. active cancer.