inclusion criteria: 1. male or females aged ≥ 18 years 2. critically ill patients with covid-19 (defined as ordinal scale score of 7): hospitalized, on invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo) for less than 72 hours. 3. evidence of pneumonia (pulmonary infiltrates) at chest radiography or computed tomography compatible with covid-19. 4. laboratory-confirmed novel coronavirus (sars-cov-2) infection as determined by polymerase chain reaction (pcr). 5. subject (or legally authorized representative) provides written or oral informed consent prior to initiation of any study procedures. 6. women of childbearing potential and their partner must agree to use at least one highly effective method of contraception (e.g., hormonal contraceptives \[implants, injectables, combination oral contraceptives, transdermal patches, or contraceptive rings\], intrauterine devices, bilateral tubal occlusion, or sexual abstinence) for the duration of the study.

inclusion criteria: 1. male or females aged ≥ 18 years 2. critically ill patients with covid-19 (defined as ordinal scale score of 7): hospitalized, on invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo) for less than 72 hours. 3. evidence of pneumonia (pulmonary infiltrates) at chest radiography or computed tomography compatible with covid-19. 4. laboratory-confirmed novel coronavirus (sars-cov-2) infection as determined by polymerase chain reaction (pcr). 5. subject (or legally authorized representative) provides written or oral informed consent prior to initiation of any study procedures. 6. women of childbearing potential and their partner must agree to use at least one highly effective method of contraception (e.g., hormonal contraceptives \[implants, injectables, combination oral contraceptives, transdermal patches, or contraceptive rings\], intrauterine devices, bilateral tubal occlusion, or sexual abstinence) for the duration of the study.

inclusion criteria: male or females aged ≥ 18 years critically ill patients with covid-19 (defined as ordinal scale score of 7): hospitalized, on invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo) for less than 72 hours. evidence of pneumonia (pulmonary infiltrates) at chest radiography or computed tomography compatible with covid-19. laboratory-confirmed novel coronavirus (sars-cov-2) infection as determined by polymerase chain reaction (pcr). subject (or legally authorized representative) provides written or oral informed consent prior to initiation of any study procedures. women of childbearing potential and their partner must agree to use at least one highly effective method of contraception (e.g., hormonal contraceptives [implants, injectables, combination oral contraceptives, transdermal patches, or contraceptive rings], intrauterine devices, bilateral tubal occlusion, or sexual abstinence) for the duration of the study.

inclusion criteria: male or females aged ≥ 18 years critically ill patients with covid-19 (defined as ordinal scale score of 7): hospitalized, on invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo) for less than 72 hours. evidence of pneumonia (pulmonary infiltrates) at chest radiography or computed tomography compatible with covid-19. laboratory-confirmed novel coronavirus (sars-cov-2) infection as determined by polymerase chain reaction (pcr). subject (or legally authorized representative) provides written or oral informed consent prior to initiation of any study procedures. women of childbearing potential and their partner must agree to use at least one highly effective method of contraception (e.g., hormonal contraceptives [implants, injectables, combination oral contraceptives, transdermal patches, or contraceptive rings], intrauterine devices, bilateral tubal occlusion, or sexual abstinence) for the duration of the study.

inclusion criteria: 1. male or females aged ≥ 18 years 2. critically ill patients with covid-19 (defined as ordinal scale score of 7): hospitalized, on invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo) for less than 72 hours. 3. evidence of pneumonia (pulmonary infiltrates) at chest radiography or computed tomography compatible with covid-19. 4. laboratory-confirmed novel coronavirus (sars-cov-2) infection as determined by polymerase chain reaction (pcr). 5. subject (or legally authorized representative) provides written or oral informed consent prior to initiation of any study procedures. 6. women of childbearing potential and their partner must agree to use at least one highly effective method of contraception (e.g., hormonal contraceptives [implants, injectables, combination oral contraceptives, transdermal patches, or contraceptive rings], intrauterine devices, bilateral tubal occlusion, or sexual abstinence) for the duration of the study.

inclusion criteria: 1. male or females aged ≥ 18 years 2. critically ill patients with covid-19 (defined as ordinal scale score of 7): hospitalized, on invasive mechanical ventilation or extracorporeal membrane oxygenation (ecmo) for less than 72 hours. 3. evidence of pneumonia (pulmonary infiltrates) at chest radiography or computed tomography compatible with covid-19. 4. laboratory-confirmed novel coronavirus (sars-cov-2) infection as determined by polymerase chain reaction (pcr). 5. subject (or legally authorized representative) provides written or oral informed consent prior to initiation of any study procedures. 6. women of childbearing potential and their partner must agree to use at least one highly effective method of contraception (e.g., hormonal contraceptives [implants, injectables, combination oral contraceptives, transdermal patches, or contraceptive rings], intrauterine devices, bilateral tubal occlusion, or sexual abstinence) for the duration of the study.