* history of any of the following per the american college of sports medicine exercise testing guidelines (american college of sports medicine et al., 2018) to be determined during a screening consultation: 1. acute myocardial infarction within the past two days 2. ongoing unstable angina 3. uncontrolled cardiac arrhythmias 4. active endocarditis 5. symptomatic severe aortic stenosis 6. decompensated heart failure 7. active pulmonary embolism, pulmonary infarction, or deep venous thrombosis 8. active myocarditis or pericarditis 9. acute aortic dissection 10. physical disability that precludes safe and adequate testing * participants who demonstrate orthostatic intolerance or oxygen desaturation (\<90%) during the exercise tolerance test will no longer be eligible for the study because it is not safe for them to exercise on a treadmill.

* history of any of the following per the american college of sports medicine exercise testing guidelines (american college of sports medicine et al., 2018) to be determined during a screening consultation: 1. acute myocardial infarction within the past two days 2. ongoing unstable angina 3. uncontrolled cardiac arrhythmias 4. active endocarditis 5. symptomatic severe aortic stenosis 6. decompensated heart failure 7. active pulmonary embolism, pulmonary infarction, or deep venous thrombosis 8. active myocarditis or pericarditis 9. acute aortic dissection 10. physical disability that precludes safe and adequate testing * participants who demonstrate orthostatic intolerance or oxygen desaturation (\<90%) during the exercise tolerance test will no longer be eligible for the study because it is not safe for them to exercise on a treadmill.

history of any of the following per the american college of sports medicine exercise testing guidelines (american college of sports medicine et al., 2018) to be determined during a screening consultation: acute myocardial infarction within the past two days ongoing unstable angina uncontrolled cardiac arrhythmias active endocarditis symptomatic severe aortic stenosis decompensated heart failure active pulmonary embolism, pulmonary infarction, or deep venous thrombosis active myocarditis or pericarditis acute aortic dissection physical disability that precludes safe and adequate testing participants who demonstrate orthostatic intolerance or oxygen desaturation (<90%) during the exercise tolerance test will no longer be eligible for the study because it is not safe for them to exercise on a treadmill.

history of any of the following per the american college of sports medicine exercise testing guidelines (american college of sports medicine et al., 2018) to be determined during a screening consultation: acute myocardial infarction within the past two days ongoing unstable angina uncontrolled cardiac arrhythmias active endocarditis symptomatic severe aortic stenosis decompensated heart failure active pulmonary embolism, pulmonary infarction, or deep venous thrombosis active myocarditis or pericarditis acute aortic dissection physical disability that precludes safe and adequate testing participants who demonstrate orthostatic intolerance or oxygen desaturation (<90%) during the exercise tolerance test will no longer be eligible for the study because it is not safe for them to exercise on a treadmill.

- history of any of the following per the american college of sports medicine exercise testing guidelines (american college of sports medicine et al., 2018) to be determined during a screening consultation: 1. acute myocardial infarction within the past two days 2. ongoing unstable angina 3. uncontrolled cardiac arrhythmias 4. active endocarditis 5. symptomatic severe aortic stenosis 6. decompensated heart failure 7. active pulmonary embolism, pulmonary infarction, or deep venous thrombosis 8. active myocarditis or pericarditis 9. acute aortic dissection 10. physical disability that precludes safe and adequate testing - participants who demonstrate orthostatic intolerance or oxygen desaturation (<90%) during the exercise tolerance test will no longer be eligible for the study because it is not safe for them to exercise on a treadmill.

- history of any of the following per the american college of sports medicine exercise testing guidelines (american college of sports medicine et al., 2018) to be determined during a screening consultation: 1. acute myocardial infarction within the past two days 2. ongoing unstable angina 3. uncontrolled cardiac arrhythmias 4. active endocarditis 5. symptomatic severe aortic stenosis 6. decompensated heart failure 7. active pulmonary embolism, pulmonary infarction, or deep venous thrombosis 8. active myocarditis or pericarditis 9. acute aortic dissection 10. physical disability that precludes safe and adequate testing - participants who demonstrate orthostatic intolerance or oxygen desaturation (<90%) during the exercise tolerance test will no longer be eligible for the study because it is not safe for them to exercise on a treadmill.